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PMID:11707492

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Citation

Hardie, RC (2001) Phototransduction in Drosophila melanogaster. J. Exp. Biol. 204:3403-9

Abstract

As in most invertebrate microvillar photoreceptors, phototransduction in Drosophila melanogaster uses a G-protein-coupled phosphoinositide pathway, whereby hydrolysis of phosphatidyl inositol 4,5-bisphosphate (PIP(2)) by phospholipase C generates inositol 1,4,5-trisphosphate (InsP(3)) and diacyl glycerol (DAG), leading to activation of two classes of Ca(2+)-permeable light-sensitive channel, encoded by the trp and trpl genes. In some invertebrate photoreceptors, excitation is mediated by release of Ca(2+) from intracellular stores by InsP(3); however, in Drosophila melanogaster, recent evidence suggests instead that a lipid messenger, such as DAG, its metabolites and/or the reduction in PIP(2) levels, may mediate excitation. Like vertebrate rods, Drosophila melanogaster photoreceptors generate quantum bumps in response to single photons, but their kinetics is approximately 10-100 times faster, and this reflects a fundamentally different strategy incorporating a threshold, positive and negative feedback by Ca(2+) acting downstream of phospholipase C and a refractory period.

Links

PubMed

Keywords

Animals; Bacterial Proteins/physiology; Calcium Channels/physiology; Calmodulin-Binding Proteins/physiology; DNA-Binding Proteins; Drosophila Proteins; Drosophila melanogaster/physiology; GTP-Binding Proteins/physiology; Membrane Proteins/physiology; Phosphatidylinositol 4,5-Diphosphate/metabolism; Phosphatidylinositols/metabolism; Photoreceptor Cells/physiology; Signal Transduction; TRPC Cation Channels; Trans-Activators; Transient Receptor Potential Channels; Type C Phospholipases/metabolism; Vision, Ocular

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:PIPA

involved_in

GO:0006651: diacylglycerol biosynthetic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:PIPA

involved_in

GO:0006644: phospholipid metabolic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:KPC2

involved_in

GO:0016059: deactivation of rhodopsin mediated signaling

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:RDGB

involved_in

GO:0007602: phototransduction

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:RDGB

enables

GO:0008526: phosphatidylinositol transfer activity

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

DROME:TRPL

enables

GO:0005261: cation channel activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

DROME:TRPL

enables

GO:0005516: calmodulin binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

DROME:CDS

involved_in

GO:0007602: phototransduction

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

DROME:DGK2

involved_in

GO:0006654: phosphatidic acid biosynthetic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:DGK2

enables

GO:0004143: diacylglycerol kinase activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

DROME:DGK2

involved_in

GO:0046834: lipid phosphorylation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:DGK2

involved_in

GO:0045494: photoreceptor cell maintenance

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:INAD

enables

GO:0005516: calmodulin binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

DROME:INAD

enables

GO:0030159: signaling receptor complex adaptor activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

DROME:INAD

involved_in

GO:0008104: protein localization

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:INAD

enables

GO:0017022: myosin binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete


See also

References

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