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DROME:H2AV

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) His2Av (synonyms: H2AvD, His2AvD)
Protein Name(s) Histone H2A.v

H2A.F/Z H2A.Z

External Links
UniProt P08985
EMBL X07485
X15549
AM294365
AM294366
AM294367
AM294368
AM294369
AM294370
AM294371
AM294372
FM245434
FM245435
FM245436
FM245437
FM245438
FM245439
FM245440
FM245441
FM245442
FM245443
FM245444
FM245445
AE014297
AY118910
S42733
PIR S08118
RefSeq NP_001262997.1
NP_524519.1
UniGene Dm.2346
ProteinModelPortal P08985
SMR P08985
BioGrid 68120
DIP DIP-23205N
IntAct P08985
MINT MINT-1547881
PaxDb P08985
PRIDE P08985
EnsemblMetazoa FBtr0085062
GeneID 43229
KEGG dme:Dmel_CG5499
CTD 43229
FlyBase FBgn0001197
eggNOG COG5262
GeneTree ENSGT00710000106735
InParanoid P08985
KO K11251
OMA IHRYLMN
OrthoDB EOG7M0NTR
PhylomeDB P08985
ChiTaRS His2Av
GenomeRNAi 43229
NextBio 832825
Proteomes UP000000803
Bgee P08985
GO GO:0005694
GO:0005811
GO:0000786
GO:0005634
GO:0005700
GO:0005701
GO:0003677
GO:0006974
GO:0006281
GO:0007275
GO:0071168
Gene3D 1.10.20.10
InterPro IPR009072
IPR007125
IPR002119
Pfam PF00125
PRINTS PR00620
SMART SM00414
SUPFAM SSF47113
PROSITE PS00046

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000786

nucleosome

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002119

C

Seeded From UniProt

complete

GO:0000786

nucleosome

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0544

C

Seeded From UniProt

complete

GO:0000786

nucleosome

PMID:18408708[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002119
InterPro:IPR007125

F

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002119

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:10801889[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005694

chromosome

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0158

C

Seeded From UniProt

complete

GO:0005694

chromosome

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0468

C

Seeded From UniProt

complete

GO:0005694

chromosome

PMID:10801889[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005700

polytene chromosome

PMID:10801889[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005700

polytene chromosome

PMID:19685068[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005701

polytene chromosome chromocenter

PMID:18704724[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005811

lipid particle

PMID:16543254[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005811

lipid particle

PMID:16979555[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006281

DNA repair

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

GO:0006974

cellular response to DNA damage stimulus

PMID:19543366[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0035019

somatic stem cell maintenance

PMID:24244183[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0036098

male germ-line stem cell maintenance

PMID:24244183[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046982

protein heterodimerization activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009072

F

Seeded From UniProt

complete

GO:0071168

protein localization to chromatin

PMID:21444826[9]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

colocalizes_with

GO:0035267

NuA4 histone acetyltransferase complex

PMID:15528408[10]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Mavrich, TN et al. (2008) Nucleosome organization in the Drosophila genome. Nature 453 358-62 PubMed GONUTS page
  2. 2.0 2.1 2.2 Leach, TJ et al. (2000) Histone H2A.Z is widely but nonrandomly distributed in chromosomes of Drosophila melanogaster. J. Biol. Chem. 275 23267-72 PubMed GONUTS page
  3. Andreyenkova, NG et al. (2009) Localization and characteristics of DNA underreplication zone in the 75C region of intercalary heterochromatin in Drosophila melanogaster polytene chromosomes. Chromosoma 118 747-61 PubMed GONUTS page
  4. Andreyeva, EN et al. (2008) Local DNA underreplication correlates with accumulation of phosphorylated H2Av in the Drosophila melanogaster polytene chromosomes. Chromosome Res. 16 851-62 PubMed GONUTS page
  5. Beller, M et al. (2006) Characterization of the Drosophila lipid droplet subproteome. Mol. Cell Proteomics 5 1082-94 PubMed GONUTS page
  6. Cermelli, S et al. (2006) The lipid-droplet proteome reveals that droplets are a protein-storage depot. Curr. Biol. 16 1783-95 PubMed GONUTS page
  7. Ravi, D et al. (2009) A network of conserved damage survival pathways revealed by a genomic RNAi screen. PLoS Genet. 5 e1000527 PubMed GONUTS page
  8. 8.0 8.1 Morillo Prado, JR et al. (2013) The histone variant His2Av is required for adult stem cell maintenance in the Drosophila testis. PLoS Genet. 9 e1003903 PubMed GONUTS page
  9. Kotova, E et al. (2011) Drosophila histone H2A variant (H2Av) controls poly(ADP-ribose) polymerase 1 (PARP1) activation in chromatin. Proc. Natl. Acad. Sci. U.S.A. 108 6205-10 PubMed GONUTS page
  10. Kusch, T et al. (2004) Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. Science 306 2084-7 PubMed GONUTS page