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DROME:GPDA

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Gpdh
Protein Name(s) Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

GPD-C GPDH-C

External Links
UniProt P13706
EMBL J04567
J04567
J04567
X14179
X14179
X14179
X67650
X61223
X61224
AE014134
AE014134
AE014134
AY058492
X80204
M13786
J03927
J03927
J03927
PIR S06758
S06759
S06760
S21963
RefSeq NP_001260111.1
NP_001260112.1
NP_001260113.1
NP_476565.1
NP_476566.1
NP_476567.1
UniGene Dm.4843
ProteinModelPortal P13706
SMR P13706
BioGrid 59989
DIP DIP-21689N
IntAct P13706
PaxDb P13706
GeneID 33824
KEGG dme:Dmel_CG9042
CTD 33824
FlyBase FBgn0001128
eggNOG COG0240
InParanoid P13706
KO K00006
OMA WRAGKQI
OrthoDB EOG7ZKSBS
PhylomeDB P13706
Reactome REACT_211073
REACT_220033
UniPathway UPA00086
GenomeRNAi 33824
NextBio 785441
PRO PR:P13706
Proteomes UP000000803
Bgee P13706
ExpressionAtlas P13706
GO GO:0009331
GO:0005811
GO:0031430
GO:0030018
GO:0004367
GO:0051287
GO:0005975
GO:0007629
GO:0046168
GO:0006650
GO:0006641
Gene3D 1.10.1040.10
3.40.50.720
InterPro IPR008927
IPR013328
IPR006168
IPR006109
IPR017751
IPR011128
IPR016040
PANTHER PTHR11728
Pfam PF07479
PF01210
PIRSF PIRSF000114
PRINTS PR00077
SUPFAM SSF48179
TIGRFAMs TIGR03376
PROSITE PS00957

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0006067

ethanol metabolic process

PMID:19033156[1]

IMP: Inferred from Mutant Phenotype

P

Figure 2 shows increased lethality with gene deletion and increased survival with gene duplication

complete
CACAO 6596

GO:0004367

glycerol-3-phosphate dehydrogenase [NAD+] activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006109
InterPro:IPR006168
InterPro:IPR017751

F

Seeded From UniProt

complete

GO:0004367

glycerol-3-phosphate dehydrogenase [NAD+] activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.1.1.8

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0005811

lipid particle

PMID:16543254[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005975

carbohydrate metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006109

P

Seeded From UniProt

complete

GO:0006067

ethanol metabolic process

PMID:19033156[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006072

glycerol-3-phosphate metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006168

P

Seeded From UniProt

complete

GO:0006641

triglyceride metabolic process

PMID:16204217[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006650

glycerophospholipid metabolic process

GO_REF:0000041

IEA: Inferred from Electronic Annotation

UniPathway:UPA00086

P

Seeded From UniProt

complete

GO:0007629

flight behavior

PMID:16204217[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009331

glycerol-3-phosphate dehydrogenase complex

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006168

C

Seeded From UniProt

complete

GO:0016491

oxidoreductase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013328

F

Seeded From UniProt

complete

GO:0016491

oxidoreductase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

GO:0016616

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011128

F

Seeded From UniProt

complete

GO:0030018

Z disc

PMID:12756285[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0031430

M band

PMID:12756285[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0042803

protein homodimerization activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017751

F

Seeded From UniProt

complete

GO:0046168

glycerol-3-phosphate catabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011128

P

Seeded From UniProt

complete

GO:0051287

NAD binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011128
InterPro:IPR017751

F

Seeded From UniProt

complete

GO:0055114

oxidation-reduction process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006109
InterPro:IPR006168
InterPro:IPR008927
InterPro:IPR011128
InterPro:IPR013328
InterPro:IPR017751

P

Seeded From UniProt

complete

GO:0055114

oxidation-reduction process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Eanes, WF et al. (2009) Direct evidence that genetic variation in glycerol-3-phosphate and malate dehydrogenase genes (Gpdh and Mdh1) affects adult ethanol tolerance in Drosophila melanogaster. Genetics 181 607-14 PubMed GONUTS page
  2. Beller, M et al. (2006) Characterization of the Drosophila lipid droplet subproteome. Mol. Cell Proteomics 5 1082-94 PubMed GONUTS page
  3. 3.0 3.1 Merritt, TJ et al. (2006) Triglyceride pools, flight and activity variation at the Gpdh locus in Drosophila melanogaster. Genetics 172 293-304 PubMed GONUTS page
  4. 4.0 4.1 Sullivan, DT et al. (2003) Analysis of glycolytic enzyme co-localization in Drosophila flight muscle. J. Exp. Biol. 206 2031-8 PubMed GONUTS page