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DROME:FDL

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) fdl
Protein Name(s) Probable beta-hexosaminidase fdl

Protein fused lobes

External Links
UniProt Q8WSF3
EMBL AF323977
AE013599
AE013599
AY113418
AY061037
RefSeq NP_001286350.1
NP_725178.2
NP_725179.1
UniGene Dm.3735
ProteinModelPortal Q8WSF3
SMR Q8WSF3
BioGrid 75345
DIP DIP-21467N
MINT MINT-1665363
STRING 7227.FBpp0087058
CAZy GH20
PaxDb Q8WSF3
PRIDE Q8WSF3
EnsemblMetazoa FBtr0087946
GeneID 250735
KEGG dme:Dmel_CG8824
CTD 250735
FlyBase FBgn0045063
eggNOG COG3525
GeneTree ENSGT00390000008107
InParanoid Q8WSF3
KO K12373
OMA VYKHRPW
OrthoDB EOG79W94H
PhylomeDB Q8WSF3
Reactome REACT_180740
REACT_180747
REACT_180778
REACT_212275
ChiTaRS fdl
GenomeRNAi 250735
NextBio 843498
Proteomes UP000000803
Bgee Q8WSF3
ExpressionAtlas Q8WSF3
GO GO:0005770
GO:0005886
GO:0016231
GO:0004563
GO:0007420
GO:0006491
Gene3D 3.20.20.80
3.30.379.10
InterPro IPR025705
IPR029018
IPR015883
IPR013781
IPR017853
IPR029019
Pfam PF00728
PF14845
PIRSF PIRSF001093
PRINTS PR00738
SUPFAM SSF51445
SSF55545

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004553

hydrolase activity, hydrolyzing O-glycosyl compounds

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015883

F

Seeded From UniProt

complete

GO:0004563

beta-N-acetylhexosaminidase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR025705

F

Seeded From UniProt

complete

GO:0004563

beta-N-acetylhexosaminidase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.2.1.52

F

Seeded From UniProt

complete

GO:0004563

beta-N-acetylhexosaminidase activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P49010

F

Seeded From UniProt

complete

GO:0005770

late endosome

PMID:16339150[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:16339150[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:16733265[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005975

carbohydrate metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013781
InterPro:IPR015883

P

Seeded From UniProt

complete

GO:0006491

N-glycan processing

PMID:16339150[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006491

N-glycan processing

PMID:24785692[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006517

protein deglycosylation

PMID:24785692[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007420

brain development

PMID:10623899[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007420

brain development

PMID:10623899[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008152

metabolic process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0326

P

Seeded From UniProt

complete

GO:0016063

rhodopsin biosynthetic process

PMID:24785692[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016231

beta-N-acetylglucosaminidase activity

PMID:16339150[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0016798

hydrolase activity, acting on glycosyl bonds

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0326

F

Seeded From UniProt

complete

NOT

GO:0006032

chitin catabolic process

PMID:16339150[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

NOT

GO:0032428

beta-N-acetylgalactosaminidase activity

PMID:16339150[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

colocalizes_with

GO:0005783

endoplasmic reticulum

PMID:16339150[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

colocalizes_with

GO:0005794

Golgi apparatus

PMID:16339150[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Léonard, R et al. (2006) The Drosophila fused lobes gene encodes an N-acetylglucosaminidase involved in N-glycan processing. J. Biol. Chem. 281 4867-75 PubMed GONUTS page
  2. Cattaneo, F et al. (2006) Identification and expression analysis of Drosophila melanogaster genes encoding beta-hexosaminidases of the sperm plasma membrane. Glycobiology 16 786-800 PubMed GONUTS page
  3. 3.0 3.1 3.2 Rosenbaum, EE et al. (2014) Mutations in four glycosyl hydrolases reveal a highly coordinated pathway for rhodopsin biosynthesis and N-glycan trimming in Drosophila melanogaster. PLoS Genet. 10 e1004349 PubMed GONUTS page
  4. 4.0 4.1 Boquet, I et al. (2000) Central brain postembryonic development in Drosophila: implication of genes expressed at the interhemispheric junction. J. Neurobiol. 42 33-48 PubMed GONUTS page