PMID:10623899

Citation	Boquet, I, Hitier, R, Dumas, M, Chaminade, M and Préat, T (2000) Central brain postembryonic development in Drosophila: implication of genes expressed at the interhemispheric junction. J. Neurobiol. 42:33-48
Abstract	Postembryonic brain development of Drosophila has become recently a subject of intense investigations. In particular, the linotte (lio) mutants display strong structural defects in the mushroom bodies and the central complex. The Lio kinase is expressed in a glial structure at the interhemispheric junction of late larval and young pupal brain. With the aim of identifying new genes involved in the formation of adult central brain structures, 821 enhancer-trap Gal4 lines were generated and screened for late larval expression. We identified 167 lines showing expression at or near the interhemispheric junction of third-instar larval brain, an area from which the central complex differentiates. Adult brains from 104 of these 167 lines were analyzed through paraffin sections. This secondary screen allowed the recovery of five central brain mutants. Of 89 control lines showing various patterns of expression excluding the interhemispheric junction, only one anatomical mutant was isolated. These six mutations, which have been thoroughly characterized, affect the midline area of the adult brain with phenotypes of split central complex structures and/or fused mushroom body lobes. This work opens the way for further analysis of the molecular and cellular events involved in central brain reorganization during metamorphosis.
Links	PubMed
Keywords	Animals; Brain/growth & development; Drosophila/genetics; Drosophila/growth & development; Larva/growth & development; Metamorphosis, Biological/genetics; Mutagenesis/genetics; Neuropil/physiology; Pupa/growth & development
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