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DROME:DYRK2

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) smi35A (synonyms: Dyrk2)
Protein Name(s) Dual specificity tyrosine-phosphorylation-regulated kinase 2

Protein smell impaired at 35A dDyrk2

External Links
UniProt Q9V3D5
EMBL AF168467
AE014134
AE014134
AE014134
AE014134
AE014134
BT010088
AY069183
RefSeq NP_001033906.1
NP_001033907.1
NP_523564.1
NP_995710.1
NP_995711.1
UniGene Dm.2597
ProteinModelPortal Q9V3D5
SMR Q9V3D5
IntAct Q9V3D5
PRIDE Q9V3D5
EnsemblMetazoa FBtr0089288
FBtr0089289
FBtr0089290
FBtr0100447
FBtr0100448
GeneID 34831
KEGG dme:Dmel_CG4551
CTD 8445
FlyBase FBgn0016930
eggNOG COG0515
GeneTree ENSGT00760000119032
InParanoid Q9V3D5
KO K18669
OrthoDB EOG77127N
PhylomeDB Q9V3D5
SignaLink Q9V3D5
ChiTaRS smi35A
GenomeRNAi 34831
NextBio 790436
PRO PR:Q9V3D5
Proteomes UP000000803
Bgee Q9V3D5
ExpressionAtlas Q9V3D5
GO GO:0005829
GO:0005524
GO:0004672
GO:0004674
GO:0004712
GO:0004713
GO:0016740
GO:0042048
GO:0006468
GO:0009416
GO:0007608
InterPro IPR011009
IPR000719
IPR017441
IPR002290
IPR008271
Pfam PF00069
SMART SM00220
SUPFAM SSF56112
PROSITE PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0042048

olfactory behavior

PMID:24146926[1]

IMP: Inferred from Mutant Phenotype

P

Figure 2 shows a t-maze assay using 1% benzaldehyde. Aversion was calculated with a response index and both mutant male and female DmDyrk2−/− mutants showed significantly less aversion to benzaldehyde.

complete
CACAO 8965

GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290
InterPro:IPR008271

F

Seeded From UniProt

complete

GO:0004672

protein kinase activity

PMID:10908587[2]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

PMID:10471707[3]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0004674

protein serine/threonine kinase activity

PMID:12786602[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004712

protein serine/threonine/tyrosine kinase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.12.1

F

Seeded From UniProt

complete

GO:0004713

protein tyrosine kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0829

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290
InterPro:IPR017441

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005524

ATP binding

PMID:12786602[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0005829

cytosol

PMID:12786602[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290
InterPro:IPR008271

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:10908587[2]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:12786602[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007608

sensory perception of smell

PMID:24146926[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009416

response to light stimulus

PMID:24146926[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016301

kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

GO:0016310

phosphorylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0016740

transferase activity

PMID:12786602[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0829

P

Seeded From UniProt

complete

GO:0042048

olfactory behavior

PMID:8722782[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Luebbering, N et al. (2013) Drosophila Dyrk2 plays a role in the development of the visual system. PLoS ONE 8 e76775 PubMed GONUTS page
  2. 2.0 2.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
  3. Ashburner, M et al. (1999) An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster: the Adh region. Genetics 153 179-219 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Lochhead, PA et al. (2003) dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila. Biochem. J. 374 381-91 PubMed GONUTS page
  5. Anholt, RR et al. (1996) Effects of single P-element insertions on olfactory behavior in Drosophila melanogaster. Genetics 143 293-301 PubMed GONUTS page