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DROME:DUOX

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Duox
Protein Name(s) Dual oxidase
External Links
UniProt Q9VQH2
EMBL AE014134
BT015247
RefSeq NP_001259968.1
NP_608715.2
UniGene Dm.11399
ProteinModelPortal Q9VQH2
PaxDb Q9VQH2
EnsemblMetazoa FBtr0300382
GeneID 33477
KEGG dme:Dmel_CG3131
CTD 565097
FlyBase FBgn0031464
eggNOG COG5126
GeneTree ENSGT00550000074350
HOGENOM HOG000245217
InParanoid Q9VQH2
KO K13411
OMA QPKIRIE
OrthoDB EOG7966FP
PhylomeDB Q9VQH2
GenomeRNAi 33477
NextBio 783776
Proteomes UP000000803
Bgee Q9VQH2
ExpressionAtlas Q9VQH2
GO GO:0012505
GO:0016021
GO:0005509
GO:0020037
GO:0016174
GO:0004601
GO:0008365
GO:0048085
GO:0042335
GO:0019221
GO:0042742
GO:0042744
GO:0002385
GO:0043066
GO:0072593
GO:0051591
GO:0035220
Gene3D 1.10.238.10
1.10.640.10
InterPro IPR011992
IPR018247
IPR002048
IPR013112
IPR017927
IPR013130
IPR013121
IPR010255
IPR019791
IPR017938
Pfam PF03098
PF00036
PF13405
PF08022
PF01794
PF08030
PRINTS PR00457
SMART SM00054
SUPFAM SSF48113
SSF63380
PROSITE PS00018
PS50222
PS51384
PS50292

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0002385

mucosal immune response

PMID:19289084[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0002385

mucosal immune response

PMID:19668222[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0002385

mucosal immune response

PMID:25639794[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0004601

peroxidase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010255

F

Seeded From UniProt

complete

GO:0004601

peroxidase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0575

F

Seeded From UniProt

complete

GO:0004601

peroxidase activity

PMID:16272120[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005509

calcium ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002048

F

Seeded From UniProt

complete

GO:0006979

response to oxidative stress

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010255

P

Seeded From UniProt

complete

GO:0008365

adult chitin-based cuticle development

PMID:21808060[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0012505

endomembrane system

PMID:19317464[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016174

NAD(P)H oxidase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.6.3.1

F

Seeded From UniProt

complete

GO:0016491

oxidoreductase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013112
InterPro:IPR013121
InterPro:IPR017927
InterPro:IPR017938

F

Seeded From UniProt

complete

GO:0016491

oxidoreductase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

GO:0019221

cytokine-mediated signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q9NRD9

P

Seeded From UniProt

complete

GO:0020037

heme binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010255

F

Seeded From UniProt

complete

GO:0035220

wing disc development

PMID:21808060[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042335

cuticle development

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q9NRD9

P

Seeded From UniProt

complete

GO:0042742

defense response to bacterium

PMID:16272120[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042744

hydrogen peroxide catabolic process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0376

P

Seeded From UniProt

complete

GO:0043066

negative regulation of apoptotic process

PMID:21808060[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0048085

adult chitin-containing cuticle pigmentation

PMID:21808060[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051591

response to cAMP

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q9NRD8

P

Seeded From UniProt

complete

GO:0055114

oxidation-reduction process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010255
InterPro:IPR013112
InterPro:IPR013121
InterPro:IPR017927
InterPro:IPR017938

P

Seeded From UniProt

complete

GO:0055114

oxidation-reduction process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

GO:0072593

reactive oxygen species metabolic process

PMID:21808060[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Ha, EM et al. (2009) Regulation of DUOX by the Galphaq-phospholipase Cbeta-Ca2+ pathway in Drosophila gut immunity. Dev. Cell 16 386-97 PubMed GONUTS page
  2. Ha, EM et al. (2009) Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut. Nat. Immunol. 10 949-57 PubMed GONUTS page
  3. Lee, KA et al. (2015) Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes. Cell Host Microbe 17 191-204 PubMed GONUTS page
  4. 4.0 4.1 Ha, EM et al. (2005) A direct role for dual oxidase in Drosophila gut immunity. Science 310 847-50 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 Anh, NT et al. (2011) Essential role of Duox in stabilization of Drosophila wing. J. Biol. Chem. 286 33244-51 PubMed GONUTS page
  6. Tan, DJ et al. (2009) Mapping organelle proteins and protein complexes in Drosophila melanogaster. J. Proteome Res. 8 2667-78 PubMed GONUTS page