GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

DROME:DUOX

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Duox
Protein Name(s) Dual oxidase
External Links
UniProt Q9VQH2
EMBL AE014134
BT015247
RefSeq NP_001259968.1
NP_608715.2
UniGene Dm.11399
ProteinModelPortal Q9VQH2
PaxDb Q9VQH2
EnsemblMetazoa FBtr0300382
GeneID 33477
KEGG dme:Dmel_CG3131
CTD 565097
FlyBase FBgn0031464
eggNOG COG5126
GeneTree ENSGT00550000074350
HOGENOM HOG000245217
InParanoid Q9VQH2
KO K13411
OMA QPKIRIE
OrthoDB EOG7966FP
PhylomeDB Q9VQH2
GenomeRNAi 33477
NextBio 783776
Proteomes UP000000803
Bgee Q9VQH2
ExpressionAtlas Q9VQH2
GO GO:0012505
GO:0016021
GO:0005509
GO:0020037
GO:0016174
GO:0004601
GO:0008365
GO:0048085
GO:0042335
GO:0019221
GO:0042742
GO:0042744
GO:0002385
GO:0043066
GO:0072593
GO:0051591
GO:0035220
Gene3D 1.10.238.10
1.10.640.10
InterPro IPR011992
IPR018247
IPR002048
IPR013112
IPR017927
IPR013130
IPR013121
IPR010255
IPR019791
IPR017938
Pfam PF03098
PF00036
PF13405
PF08022
PF01794
PF08030
PRINTS PR00457
SMART SM00054
SUPFAM SSF48113
SSF63380
PROSITE PS00018
PS50222
PS51384
PS50292

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0051591

response to cAMP

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9NRD8

P

Seeded From UniProt

complete

involved_in

GO:0042335

cuticle development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9NRD9

P

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9NRD9

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0283531
MGI:MGI:1354184
MGI:MGI:2450016
MGI:MGI:2681162
PANTHER:PTN001735877
PomBase:SPBC1683.09c
RGD:620600
SGD:S000003128
SGD:S000004037
SGD:S000005512
TAIR:locus:2017789
TAIR:locus:2024603
TAIR:locus:2025351
TAIR:locus:2025366
TAIR:locus:2157032
TAIR:locus:2157348
TAIR:locus:2157697
TAIR:locus:2160917
TAIR:locus:2178677
TAIR:locus:2178687
UniProtKB:P04839
UniProtKB:Q96PH1
UniProtKB:Q9NPH5
UniProtKB:Q9NRD8
UniProtKB:Q9SBI0
UniProtKB:Q9Y5S8
WB:WBGene00000253
dictyBase:DDB_G0287101
dictyBase:DDB_G0289653

P

Seeded From UniProt

complete

part_of

GO:0043020

NADPH oxidase complex

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2681162
MGI:MGI:88574
PANTHER:PTN000239643
RGD:620574
RGD:620598
RGD:620600
UniProtKB:P04839
UniProtKB:Q9Y5S8

C

Seeded From UniProt

complete

involved_in

GO:0042554

superoxide anion generation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1354184
MGI:MGI:2450016
MGI:MGI:2681162
PANTHER:PTN000239643
RGD:620598
UniProtKB:P04839
UniProtKB:Q96PH1
UniProtKB:Q9Y5S8
dictyBase:DDB_G0287101

P

Seeded From UniProt

complete

enables

GO:0016175

superoxide-generating NADPH oxidase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1354184
MGI:MGI:2450016
MGI:MGI:2681162
PANTHER:PTN000239643
UniProtKB:Q96PH1
UniProtKB:Q9Y5S8
dictyBase:DDB_G0287101
dictyBase:DDB_G0289653

F

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0283531
MGI:MGI:88574
PANTHER:PTN000239643
UniProtKB:P04839
ZFIN:ZDB-GENE-091117-14
dictyBase:DDB_G0287101
dictyBase:DDB_G0289653
dictyBase:DDB_G0291117

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2139422
MGI:MGI:2681162
MGI:MGI:88574
PANTHER:PTN001735877
RGD:620574
RGD:620598
RGD:620600
SGD:S000005512
TAIR:locus:2024603
TAIR:locus:2025351
TAIR:locus:2157027
TAIR:locus:2157348
TAIR:locus:2157697
TAIR:locus:2160917
UniProtKB:O81209
UniProtKB:P04839
UniProtKB:Q9Y5S8
WB:WBGene00000253

C

Seeded From UniProt

complete

involved_in

GO:0009611

response to wounding

PMID:28289197[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002385

mucosal immune response

PMID:25639794[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0012505

endomembrane system

PMID:19317464[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:21808060[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072593

reactive oxygen species metabolic process

PMID:21808060[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035220

wing disc development

PMID:21808060[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048085

adult chitin-containing cuticle pigmentation

PMID:21808060[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008365

adult chitin-based cuticle development

PMID:21808060[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002385

mucosal immune response

PMID:19668222[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002385

mucosal immune response

PMID:19289084[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

PMID:16272120[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004601

peroxidase activity

PMID:16272120[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007476

imaginal disc-derived wing morphogenesis

DOI:10.1002/9780470720110.ch8

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004601

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004601

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004601

P

Seeded From UniProt

complete

enables

GO:0004601

peroxidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010255

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002048

F

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010255

P

Seeded From UniProt

complete

enables

GO:0016174

NAD(P)H oxidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029595

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013112
InterPro:IPR013121
InterPro:IPR017927

F

Seeded From UniProt

complete

enables

GO:0020037

heme binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010255

F

Seeded From UniProt

complete

involved_in

GO:0050665

hydrogen peroxide biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029595

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010255
InterPro:IPR013112
InterPro:IPR013121
InterPro:IPR017927

P

Seeded From UniProt

complete

enables

GO:0016174

NAD(P)H oxidase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.6.3.1

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0042744

hydrogen peroxide catabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0376

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

enables

GO:0004601

peroxidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0575

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ Capilla, A et al. (2017) Toll pathway is required for wound-induced expression of barrier repair genes in the epidermis. Proc. Natl. Acad. Sci. U.S.A. 114 E2682-E2688 PubMed GONUTS page
  3. ↑ Lee, KA et al. (2015) Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes. Cell Host Microbe 17 191-204 PubMed GONUTS page
  4. ↑ Tan, DJ et al. (2009) Mapping organelle proteins and protein complexes in Drosophila melanogaster. J. Proteome Res. 8 2667-78 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Anh, NT et al. (2011) Essential role of Duox in stabilization of Drosophila wing. J. Biol. Chem. 286 33244-51 PubMed GONUTS page
  6. ↑ Ha, EM et al. (2009) Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut. Nat. Immunol. 10 949-57 PubMed GONUTS page
  7. ↑ Ha, EM et al. (2009) Regulation of DUOX by the Galphaq-phospholipase Cbeta-Ca2+ pathway in Drosophila gut immunity. Dev. Cell 16 386-97 PubMed GONUTS page
  8. ↑ 8.0 8.1 Ha, EM et al. (2005) A direct role for dual oxidase in Drosophila gut immunity. Science 310 847-50 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=DROME:DUOX&oldid=5954013"