DROME:DOPR2

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Dop1R2 (synonyms: DAMB, DopR2, DopR99B)
Protein Name(s)	Dopamine receptor 2 Dopamine 1-like receptor 2
External Links
UniProt	Q24563
EMBL	U34383 U61264 AE014297 AE014297 BT010212
RefSeq	NP_524548.1 NP_733299.1
UniGene	Dm.2334
ProteinModelPortal	Q24563
SMR	Q24563
BioGrid	68348
DIP	DIP-22945N
MINT	MINT-969408
PRIDE	Q24563
EnsemblMetazoa	FBtr0085468
GeneID	43484
KEGG	dme:Dmel_CG18741
CTD	43484
FlyBase	FBgn0266137
eggNOG	NOG253615
GeneTree	ENSGT00770000120457
InParanoid	Q24563
OrthoDB	EOG78D7KR
PhylomeDB	Q24563
Reactome	REACT_241099
GenomeRNAi	43484
NextBio	834177
Proteomes	UP000000803
Bgee	Q24563
GO	GO:0016021 GO:0005887 GO:0030285 GO:0004935 GO:0004952 GO:0001588 GO:0008227 GO:0007191 GO:0007212 GO:0007186
InterPro	IPR002233 IPR000276 IPR017452
Pfam	PF00001
PRINTS	PR01103 PR00237
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0001555	oocyte growth	PMID:8656286^[1]	ECO:0000314			P	Figure 3	complete CACAO 6058
	GO:0051620	norepinephrine uptake	PMID:8656286^[1]	ECO:0000314			P	Figure 3-Typical responses of a single oocyte to various concentrations of dopamine.B, Dose–response curves for dopamine, (−)-norepinephrine,	complete CACAO 6059
	GO:0008226	tyramine receptor activity	PMID:8656286^[1]	ECO:0000314			F	Figure 3	complete CACAO 6060
	GO:0051591	response to cAMP	PMID:8656286^[1]	ECO:0000314			P	Figure 4-Dose–response curves for increase in cAMP levels in oocytes expressing DopR99B.	complete CACAO 6061
enables	GO:0008226	tyramine receptor activity	PMID:8656286^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0030285	integral component of synaptic vesicle membrane	PMID:8663989^[2]	ECO:0000305	curator inference used in manual assertion	GO:0001588	C	Seeded From UniProt	complete
enables	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	PMID:8663989^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001205212 UniProtKB:P08588 UniProtKB:P18871	P	Seeded From UniProt	complete
involved_in	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664502 RGD:2520	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004514 FB:FBgn0035538 FB:FBgn0038541 FB:FBgn0038542 PANTHER:PTN000664502 UniProtKB:P07550 UniProtKB:P08913 UniProtKB:P14416 UniProtKB:P18825 UniProtKB:P18871 UniProtKB:P35462 WB:WBGene00004777	C	Seeded From UniProt	complete
enables	GO:0004935	adrenergic receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87934 MGI:MGI:87935 PANTHER:PTN000664502	F	Seeded From UniProt	complete
involved_in	GO:0042321	negative regulation of circadian sleep/wake cycle, sleep	PMID:27487216^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1903351	cellular response to dopamine	PMID:27487216^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1990834	response to odorant	PMID:26687359^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	PMID:26687359^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1903223	positive regulation of oxidative stress-induced neuron death	PMID:25158689^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001306	age-dependent response to oxidative stress	PMID:25158689^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008227	G protein-coupled amine receptor activity	PMID:12163486^[7]	ECO:0000250	sequence similarity evidence used in manual assertion		F	Seeded From UniProt	Missing: with/from
part_of	GO:0016021	integral component of membrane	PMID:10908591^[8]	ECO:0000250	sequence similarity evidence used in manual assertion		C	Seeded From UniProt	Missing: with/from
involved_in	GO:0007212	dopamine receptor signaling pathway	PMID:10908591^[8]	ECO:0000250	sequence similarity evidence used in manual assertion		P	Seeded From UniProt	Missing: with/from
enables	GO:0004952	dopamine neurotransmitter receptor activity	PMID:10908591^[8]	ECO:0000250	sequence similarity evidence used in manual assertion		F	Seeded From UniProt	Missing: with/from
enables	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	PMID:8663989^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:8663989^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	HGNC:3023	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:8663989^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	HGNC:280	C	Seeded From UniProt	complete
enables	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	PMID:8663989^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	FB:FBgn0011582	F	Seeded From UniProt	complete
enables	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	PMID:8663989^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	HGNC:3020	F	Seeded From UniProt	complete
involved_in	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	PMID:8656286^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	PMID:8656286^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:8656286^[1]	ECO:0000255	match to sequence model evidence used in manual assertion		C	Seeded From UniProt	Missing: with/from
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F	Seeded From UniProt	complete
enables	GO:0004935	adrenergic receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002233	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR002233	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR002233 InterPro:IPR017452	C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:8663989^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Feng, G et al. (1996) Cloning and functional characterization of a novel dopamine receptor from Drosophila melanogaster. J. Neurosci. 16 3925-33 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Han, KA et al. (1996) DAMB, a novel dopamine receptor expressed specifically in Drosophila mushroom bodies. Neuron 16 1127-35 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Pimentel, D et al. (2016) Operation of a homeostatic sleep switch. Nature 536 333-337 PubMed GONUTS page
↑ ^5.0 ^5.1 Cohn, R et al. (2015) Coordinated and Compartmentalized Neuromodulation Shapes Sensory Processing in Drosophila. Cell 163 1742-55 PubMed GONUTS page
↑ ^6.0 ^6.1 Cassar, M et al. (2015) A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila. Hum. Mol. Genet. 24 197-212 PubMed GONUTS page
↑ Radford, JC et al. (2002) Systematic G-protein-coupled receptor analysis in Drosophila melanogaster identifies a leucokinin receptor with novel roles. J. Biol. Chem. 277 38810-7 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Brody, T & Cravchik, A (2000) Drosophila melanogaster G protein-coupled receptors. J. Cell Biol. 150 F83-8 PubMed GONUTS page

[PMID:8656286-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Feng, G et al. (1996) Cloning and functional characterization of a novel dopamine receptor from Drosophila melanogaster. J. Neurosci. 16 3925-33 PubMed GONUTS page

[PMID:8663989-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Han, KA et al. (1996) DAMB, a novel dopamine receptor expressed specifically in Drosophila mushroom bodies. Neuron 16 1127-35 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:27487216-4] 4.0 ^4.1 Pimentel, D et al. (2016) Operation of a homeostatic sleep switch. Nature 536 333-337 PubMed GONUTS page

[PMID:26687359-5] 5.0 ^5.1 Cohn, R et al. (2015) Coordinated and Compartmentalized Neuromodulation Shapes Sensory Processing in Drosophila. Cell 163 1742-55 PubMed GONUTS page

[PMID:25158689-6] 6.0 ^6.1 Cassar, M et al. (2015) A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila. Hum. Mol. Genet. 24 197-212 PubMed GONUTS page

[PMID:12163486-7] Radford, JC et al. (2002) Systematic G-protein-coupled receptor analysis in Drosophila melanogaster identifies a leucokinin receptor with novel roles. J. Biol. Chem. 277 38810-7 PubMed GONUTS page

[PMID:10908591-8] 8.0 ^8.1 ^8.2 Brody, T & Cravchik, A (2000) Drosophila melanogaster G protein-coupled receptors. J. Cell Biol. 150 F83-8 PubMed GONUTS page

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DROME:DOPR2

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