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DROME:DOPR2

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Dop1R2 (synonyms: DAMB, DopR2, DopR99B)
Protein Name(s) Dopamine receptor 2

Dopamine 1-like receptor 2

External Links
UniProt Q24563
EMBL U34383
U61264
AE014297
AE014297
BT010212
RefSeq NP_524548.1
NP_733299.1
UniGene Dm.2334
ProteinModelPortal Q24563
SMR Q24563
BioGrid 68348
DIP DIP-22945N
MINT MINT-969408
PRIDE Q24563
EnsemblMetazoa FBtr0085468
GeneID 43484
KEGG dme:Dmel_CG18741
CTD 43484
FlyBase FBgn0266137
eggNOG NOG253615
GeneTree ENSGT00770000120457
InParanoid Q24563
OrthoDB EOG78D7KR
PhylomeDB Q24563
Reactome REACT_241099
GenomeRNAi 43484
NextBio 834177
Proteomes UP000000803
Bgee Q24563
GO GO:0016021
GO:0005887
GO:0030285
GO:0004935
GO:0004952
GO:0001588
GO:0008227
GO:0007191
GO:0007212
GO:0007186
InterPro IPR002233
IPR000276
IPR017452
Pfam PF00001
PRINTS PR01103
PR00237
PROSITE PS00237
PS50262

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001555

oocyte growth

PMID:8656286[1]

IDA: Inferred from Direct Assay

P

Figure 3

complete
CACAO 6058

GO:0051620

norepinephrine uptake

PMID:8656286[1]

IDA: Inferred from Direct Assay

P

Figure 3-Typical responses of a single oocyte to various concentrations of dopamine.B, Dose–response curves for dopamine, (−)-norepinephrine,

complete
CACAO 6059

GO:0008226

tyramine receptor activity

PMID:8656286[1]

IDA: Inferred from Direct Assay

F

Figure 3

complete
CACAO 6060

GO:0051591

response to cAMP

PMID:8656286[1]

IDA: Inferred from Direct Assay

P

Figure 4-Dose–response curves for increase in cAMP levels in oocytes expressing DopR99B.

complete
CACAO 6061

GO:0001306

age-dependent response to oxidative stress

PMID:25158689[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0001588

dopamine neurotransmitter receptor activity, coupled via Gs

PMID:8656286[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0001588

dopamine neurotransmitter receptor activity, coupled via Gs

PMID:8663989[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0001588

dopamine neurotransmitter receptor activity, coupled via Gs

PMID:8663989[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0001588

dopamine neurotransmitter receptor activity, coupled via Gs

PMID:8663989[3]

ISS: Inferred from Sequence or Structural Similarity

FB:FBgn0011582

F

Seeded From UniProt

complete

GO:0001588

dopamine neurotransmitter receptor activity, coupled via Gs

PMID:8663989[3]

ISS: Inferred from Sequence or Structural Similarity

HGNC:3020

F

Seeded From UniProt

complete

GO:0004871

signal transducer activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0807

F

Seeded From UniProt

complete

GO:0004930

G-protein coupled receptor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000276

F

Seeded From UniProt

complete

GO:0004930

G-protein coupled receptor activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

GO:0004935

adrenergic receptor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002233

F

Seeded From UniProt

complete

GO:0004952

dopamine neurotransmitter receptor activity

PMID:10908591[4]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0005886

plasma membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:8663989[3]

ISS: Inferred from Sequence or Structural Similarity

HGNC:280

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:8663989[3]

ISS: Inferred from Sequence or Structural Similarity

HGNC:3023

C

Seeded From UniProt

complete

GO:0005887

integral component of plasma membrane

PMID:8656286[1]

ISM: Inferred from Sequence Model

C

Seeded From UniProt

Missing: with/from

GO:0007165

signal transduction

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

GO:0007186

G-protein coupled receptor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000276
InterPro:IPR002233

P

Seeded From UniProt

complete

GO:0007186

G-protein coupled receptor signaling pathway

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

GO:0007186

G-protein coupled receptor signaling pathway

PMID:8663989[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007191

adenylate cyclase-activating dopamine receptor signaling pathway

PMID:8656286[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007212

dopamine receptor signaling pathway

PMID:10908591[4]

ISS: Inferred from Sequence or Structural Similarity

P

Seeded From UniProt

Missing: with/from

GO:0008226

tyramine receptor activity

PMID:8656286[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0008227

G-protein coupled amine receptor activity

PMID:12163486[5]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000276
InterPro:IPR002233
InterPro:IPR017452

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

PMID:10908591[4]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0030285

integral component of synaptic vesicle membrane

PMID:8663989[3]

IC: Inferred by Curator

GO:0001588

C

Seeded From UniProt

complete

GO:0071875

adrenergic receptor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002233

P

Seeded From UniProt

complete

GO:1903223

positive regulation of oxidative stress-induced neuron death

PMID:25158689[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Feng, G et al. (1996) Cloning and functional characterization of a novel dopamine receptor from Drosophila melanogaster. J. Neurosci. 16 3925-33 PubMed GONUTS page
  2. 2.0 2.1 Cassar, M et al. (2015) A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila. Hum. Mol. Genet. 24 197-212 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Han, KA et al. (1996) DAMB, a novel dopamine receptor expressed specifically in Drosophila mushroom bodies. Neuron 16 1127-35 PubMed GONUTS page
  4. 4.0 4.1 4.2 Brody, T & Cravchik, A (2000) Drosophila melanogaster G protein-coupled receptors. J. Cell Biol. 150 F83-8 PubMed GONUTS page
  5. Radford, JC et al. (2002) Systematic G-protein-coupled receptor analysis in Drosophila melanogaster identifies a leucokinin receptor with novel roles. J. Biol. Chem. 277 38810-7 PubMed GONUTS page