DROME:DDX6

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	me31B
Protein Name(s)	Putative ATP-dependent RNA helicase me31b Maternal expression at 31B
External Links
UniProt	P23128
EMBL	M59926 AE014134 AE014134 AY051663
PIR	A39157
RefSeq	NP_523533.2 NP_723539.1
UniGene	Dm.2770
ProteinModelPortal	P23128
SMR	P23128
BioGrid	60455
IntAct	P23128
MINT	MINT-769276
STRING	7227.FBpp0079565
iPTMnet	P23128
PaxDb	P23128
PRIDE	P23128
EnsemblMetazoa	FBtr0079975
GeneID	34364
KEGG	dme:Dmel_CG4916
CTD	34364
FlyBase	FBgn0004419
eggNOG	KOG0326 ENOG410XRAZ
GeneTree	ENSGT00870000136507
InParanoid	P23128
KO	K12614
OMA	IYQKVQV
OrthoDB	EOG091G0623
PhylomeDB	P23128
Reactome	[www.reactome.org/content/detail/R-DME-430039 R-DME-430039]
ChiTaRS	me31B
GenomeRNAi	34364
PRO	PR:P23128
Proteomes	UP000000803
Bgee	FBgn0004419
Genevisible	P23128
GO	GO:0005737 GO:0010494 GO:0005875 GO:0043186 GO:0000932 GO:0005524 GO:0004004 GO:0003723 GO:0033962 GO:0035195 GO:0046959 GO:0007095 GO:0030707 GO:0007279 GO:0050688 GO:0010906 GO:0090328 GO:0010501
Gene3D	3.40.50.300
InterPro	IPR011545 IPR014001 IPR001650 IPR027417 IPR000629 IPR014014
Pfam	PF00270 PF00271
SMART	SM00487 SM00490
SUPFAM	SSF52540
PROSITE	PS00039 PS51192 PS51194 PS51195

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005783	endoplasmic reticulum	PMID:16256742^[1]	ECO:0000314			C	Figure 6. E&G Me31B and Cup Colocalize with Both Tral and the ER in Egg Chambers. D–F) Tral and Me31B colocalize to the same particles in nurse cells. (E) Me31B. (G–I) Me31B particles localize to discrete sites on the ER (arrows). (G) Me31B. Drosophila.	complete CACAO 12351
involved_in	GO:1905618	positive regulation of miRNA mediated inhibition of translation	PMID:21267420^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:1990124	messenger ribonucleoprotein complex	PMID:21267420^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1990120	messenger ribonucleoprotein complex assembly	PMID:21267420^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	PMID:21267420^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0071683	sensory dendrite	PMID:21267420^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0071598	neuronal ribonucleoprotein granule	PMID:21267420^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
colocalizes_with	GO:0070971	endoplasmic reticulum exit site	PMID:16256742^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000932	P-body	PMID:16256742^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:1990124	messenger ribonucleoprotein complex	PMID:16256742^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:21267420^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0071598	neuronal ribonucleoprotein granule	PMID:17178403^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0060148	positive regulation of posttranscriptional gene silencing	PMID:11546740^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	PMID:11546740^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0150011	regulation of neuron projection arborization	PMID:17178403^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1905618	positive regulation of miRNA mediated inhibition of translation	PMID:17178403^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000766	negative regulation of cytoplasmic translation	PMID:17178403^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:1990124	messenger ribonucleoprotein complex	PMID:17178403^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030707	ovarian follicle cell development	PMID:26205122^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:25294944^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0050688	regulation of defense response to virus	PMID:25126784^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035195	gene silencing by miRNA	PMID:19029310^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0283682	P	Seeded From UniProt	complete
involved_in	GO:0046959	habituation	PMID:21795609^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0090328	regulation of olfactory learning	PMID:21795609^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0000932	P-body	PMID:21655181^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043186	P granule	PMID:21447556^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000932	P-body	PMID:20452345^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043186	P granule	PMID:18590813^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007279	pole cell formation	PMID:18590813^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0283442	P	Seeded From UniProt	complete
involved_in	GO:0007279	pole cell formation	PMID:18590813^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003891	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18708044^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000932	P-body	PMID:17595295^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0033962	cytoplasmic mRNA processing body assembly	PMID:17403906^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0000932	P-body	PMID:17403906^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:16469699^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011545	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011545	F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C	Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C	Seeded From UniProt	complete
part_of	GO:0000932	P-body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0230	C	Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0495	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Wilhelm, JE et al. (2005) Efficient protein trafficking requires trailer hitch, a component of a ribonucleoprotein complex localized to the ER in Drosophila. Dev. Cell 9 675-85 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Hillebrand, J et al. (2010) The Me31B DEAD-Box Helicase Localizes to Postsynaptic Foci and Regulates Expression of a CaMKII Reporter mRNA in Dendrites of Drosophila Olfactory Projection Neurons. Front Neural Circuits 4 121 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Barbee, SA et al. (2006) Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies. Neuron 52 997-1009 PubMed GONUTS page
↑ ^4.0 ^4.1 Nakamura, A et al. (2001) Me31B silences translation of oocyte-localizing RNAs through the formation of cytoplasmic RNP complex during Drosophila oogenesis. Development 128 3233-42 PubMed GONUTS page
↑ Jia, D et al. (2015) A large-scale in vivo RNAi screen to identify genes involved in Notch-mediated follicle cell differentiation and cell cycle switches. Sci Rep 5 12328 PubMed GONUTS page
↑ Lye, CM et al. (2014) Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Development 141 4006-17 PubMed GONUTS page
↑ Moy, RH et al. (2014) Stem-loop recognition by DDX17 facilitates miRNA processing and antiviral defense. Cell 158 764-77 PubMed GONUTS page
↑ Eulalio, A et al. (2009) Deadenylation is a widespread effect of miRNA regulation. RNA 15 21-32 PubMed GONUTS page
↑ ^9.0 ^9.1 McCann, C et al. (2011) The Ataxin-2 protein is required for microRNA function and synapse-specific long-term olfactory habituation. Proc. Natl. Acad. Sci. U.S.A. 108 E655-62 PubMed GONUTS page
↑ Fan, SJ et al. (2011) Drosophila Ge-1 promotes P body formation and oskar mRNA localization. PLoS ONE 6 e20612 PubMed GONUTS page
↑ Liu, L et al. (2011) PAPI, a novel TUDOR-domain protein, complexes with AGO3, ME31B and TRAL in the nuage to silence transposition. Development 138 1863-73 PubMed GONUTS page
↑ Cauchi, RJ et al. (2010) Drosophila SMN complex proteins Gemin2, Gemin3, and Gemin5 are components of U bodies. Exp. Cell Res. 316 2354-64 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Thomson, T et al. () Isolation of new polar granule components in Drosophila reveals P body and ER associated proteins. Mech. Dev. 125 865-73 PubMed GONUTS page
↑ Lin, MD et al. (2008) Drosophila processing bodies in oogenesis. Dev. Biol. 322 276-88 PubMed GONUTS page
↑ Liu, JL & Gall, JG (2007) U bodies are cytoplasmic structures that contain uridine-rich small nuclear ribonucleoproteins and associate with P bodies. Proc. Natl. Acad. Sci. U.S.A. 104 11655-9 PubMed GONUTS page
↑ ^16.0 ^16.1 Eulalio, A et al. (2007) P-body formation is a consequence, not the cause, of RNA-mediated gene silencing. Mol. Cell. Biol. 27 3970-81 PubMed GONUTS page
↑ Chekulaeva, M et al. (2006) Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles. Cell 124 521-33 PubMed GONUTS page

[PMID:16256742-1] 1.0 ^1.1 ^1.2 ^1.3 Wilhelm, JE et al. (2005) Efficient protein trafficking requires trailer hitch, a component of a ribonucleoprotein complex localized to the ER in Drosophila. Dev. Cell 9 675-85 PubMed GONUTS page

[PMID:21267420-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Hillebrand, J et al. (2010) The Me31B DEAD-Box Helicase Localizes to Postsynaptic Foci and Regulates Expression of a CaMKII Reporter mRNA in Dendrites of Drosophila Olfactory Projection Neurons. Front Neural Circuits 4 121 PubMed GONUTS page

[PMID:17178403-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Barbee, SA et al. (2006) Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies. Neuron 52 997-1009 PubMed GONUTS page

[PMID:11546740-4] 4.0 ^4.1 Nakamura, A et al. (2001) Me31B silences translation of oocyte-localizing RNAs through the formation of cytoplasmic RNP complex during Drosophila oogenesis. Development 128 3233-42 PubMed GONUTS page

[PMID:26205122-5] Jia, D et al. (2015) A large-scale in vivo RNAi screen to identify genes involved in Notch-mediated follicle cell differentiation and cell cycle switches. Sci Rep 5 12328 PubMed GONUTS page

[PMID:25294944-6] Lye, CM et al. (2014) Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Development 141 4006-17 PubMed GONUTS page

[PMID:25126784-7] Moy, RH et al. (2014) Stem-loop recognition by DDX17 facilitates miRNA processing and antiviral defense. Cell 158 764-77 PubMed GONUTS page

[PMID:19029310-8] Eulalio, A et al. (2009) Deadenylation is a widespread effect of miRNA regulation. RNA 15 21-32 PubMed GONUTS page

[PMID:21795609-9] 9.0 ^9.1 McCann, C et al. (2011) The Ataxin-2 protein is required for microRNA function and synapse-specific long-term olfactory habituation. Proc. Natl. Acad. Sci. U.S.A. 108 E655-62 PubMed GONUTS page

[PMID:21655181-10] Fan, SJ et al. (2011) Drosophila Ge-1 promotes P body formation and oskar mRNA localization. PLoS ONE 6 e20612 PubMed GONUTS page

[PMID:21447556-11] Liu, L et al. (2011) PAPI, a novel TUDOR-domain protein, complexes with AGO3, ME31B and TRAL in the nuage to silence transposition. Development 138 1863-73 PubMed GONUTS page

[PMID:20452345-12] Cauchi, RJ et al. (2010) Drosophila SMN complex proteins Gemin2, Gemin3, and Gemin5 are components of U bodies. Exp. Cell Res. 316 2354-64 PubMed GONUTS page

[PMID:18590813-13] 13.0 ^13.1 ^13.2 Thomson, T et al. () Isolation of new polar granule components in Drosophila reveals P body and ER associated proteins. Mech. Dev. 125 865-73 PubMed GONUTS page

[PMID:18708044-14] Lin, MD et al. (2008) Drosophila processing bodies in oogenesis. Dev. Biol. 322 276-88 PubMed GONUTS page

[PMID:17595295-15] Liu, JL & Gall, JG (2007) U bodies are cytoplasmic structures that contain uridine-rich small nuclear ribonucleoproteins and associate with P bodies. Proc. Natl. Acad. Sci. U.S.A. 104 11655-9 PubMed GONUTS page

[PMID:17403906-16] 16.0 ^16.1 Eulalio, A et al. (2007) P-body formation is a consequence, not the cause, of RNA-mediated gene silencing. Mol. Cell. Biol. 27 3970-81 PubMed GONUTS page

[PMID:16469699-17] Chekulaeva, M et al. (2006) Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles. Cell 124 521-33 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

DROME:DDX6

Contents

Annotations

Notes

References

a

b

c

d

e

f

h

i

m

n

o

p

r

s

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools