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DROME:CAZ

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) caz (synonyms: SARFH)
Protein Name(s) RNA-binding protein cabeza

P19 Sarcoma-associated RNA-binding fly homolog

External Links
UniProt Q27294
EMBL U13178
L37083
AE014298
BT004875
M15765
AY094763
PIR S54729
RefSeq NP_523365.2
UniGene Dm.2872
ProteinModelPortal Q27294
SMR Q27294
BioGrid 58928
IntAct Q27294
PaxDb Q27294
PRIDE Q27294
EnsemblMetazoa FBtr0074217
GeneID 32587
KEGG dme:Dmel_CG3606
CTD 32587
FlyBase FBgn0011571
eggNOG NOG240581
GeneTree ENSGT00530000063105
InParanoid Q27294
KO K13098
OMA FAWRNEC
OrthoDB EOG7DZ8N7
PhylomeDB Q27294
Reactome REACT_227819
ChiTaRS caz
GenomeRNAi 32587
NextBio 779303
PRO PR:Q27294
Proteomes UP000000803
Bgee Q27294
ExpressionAtlas Q27294
GO GO:0071013
GO:0005654
GO:0005634
GO:0003729
GO:0000166
GO:0008270
GO:0008344
GO:0048749
GO:0008345
GO:0000398
GO:0045887
GO:0051124
Gene3D 3.30.70.330
4.10.1060.10
InterPro IPR012677
IPR000504
IPR001876
Pfam PF00076
PF00641
SMART SM00360
SM00547
PROSITE PS50102
PS01358
PS50199

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012677

F

Seeded From UniProt

complete

GO:0000398

mRNA splicing, via spliceosome

PMID:18981222[1]

IC: Inferred by Curator

GO:0071013

P

Seeded From UniProt

complete

GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000504

F

Seeded From UniProt

complete

GO:0003723

RNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

GO:0003729

mRNA binding

PMID:10908586[2]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:21881207[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:7623847[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

PMID:22724023[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005654

nucleoplasm

PMID:24497576[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005669

transcription factor TFIID complex

PMID:10908585[7]

ISS: Inferred from Sequence or Structural Similarity

HGNC:11545

C

Seeded From UniProt

complete

GO:0006367

transcription initiation from RNA polymerase II promoter

PMID:10908585[7]

ISS: Inferred from Sequence or Structural Similarity

HGNC:11545

P

Seeded From UniProt

complete

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001876

F

Seeded From UniProt

complete

GO:0008344

adult locomotory behavior

PMID:21881207[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008344

adult locomotory behavior

PMID:22443542[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008345

larval locomotory behavior

PMID:22443542[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045887

positive regulation of synaptic growth at neuromuscular junction

PMID:24497576[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0048749

compound eye development

PMID:22443542[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051124

synaptic growth at neuromuscular junction

PMID:24497576[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0071013

catalytic step 2 spliceosome

PMID:18981222[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

colocalizes_with

GO:0035327

transcriptionally active chromatin

PMID:7623847[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Herold, N et al. (2009) Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Mol. Cell. Biol. 29 281-301 PubMed GONUTS page
  2. Lasko, P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J. Cell Biol. 150 F51-6 PubMed GONUTS page
  3. 3.0 3.1 Wang, JW et al. (2011) The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span. J. Clin. Invest. 121 4118-26 PubMed GONUTS page
  4. 4.0 4.1 Immanuel, D et al. (1995) Association of SARFH (sarcoma-associated RNA-binding fly homolog) with regions of chromatin transcribed by RNA polymerase II. Mol. Cell. Biol. 15 4562-71 PubMed GONUTS page
  5. Sasayama, H et al. (2012) Knockdown of the Drosophila fused in sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches. PLoS ONE 7 e39483 PubMed GONUTS page
  6. 6.0 6.1 6.2 Azuma, Y et al. (2014) Identification of ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS. Hum. Mol. Genet. 23 3467-80 PubMed GONUTS page
  7. 7.0 7.1 Aoyagi, N & Wassarman, DA (2000) Genes encoding Drosophila melanogaster RNA polymerase II general transcription factors: diversity in TFIIA and TFIID components contributes to gene-specific transcriptional regulation. J. Cell Biol. 150 F45-50 PubMed GONUTS page
  8. 8.0 8.1 8.2 Xia, R et al. (2012) Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS. Mol Neurodegener 7 10 PubMed GONUTS page