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DROME:CAZ
Contents
| Species (Taxon ID) | Drosophila melanogaster (Fruit fly). (7227) | |
| Gene Name(s) | caz (synonyms: SARFH) | |
| Protein Name(s) | RNA-binding protein cabeza
P19 Sarcoma-associated RNA-binding fly homolog | |
| External Links | ||
| UniProt | Q27294 | |
| EMBL | U13178 L37083 AE014298 BT004875 M15765 AY094763 | |
| PIR | S54729 | |
| RefSeq | NP_523365.2 | |
| UniGene | Dm.2872 | |
| ProteinModelPortal | Q27294 | |
| SMR | Q27294 | |
| BioGrid | 58928 | |
| IntAct | Q27294 | |
| PaxDb | Q27294 | |
| PRIDE | Q27294 | |
| EnsemblMetazoa | FBtr0074217 | |
| GeneID | 32587 | |
| KEGG | dme:Dmel_CG3606 | |
| CTD | 32587 | |
| FlyBase | FBgn0011571 | |
| eggNOG | NOG240581 | |
| GeneTree | ENSGT00530000063105 | |
| InParanoid | Q27294 | |
| KO | K13098 | |
| OMA | FAWRNEC | |
| OrthoDB | EOG7DZ8N7 | |
| PhylomeDB | Q27294 | |
| Reactome | REACT_227819 | |
| ChiTaRS | caz | |
| GenomeRNAi | 32587 | |
| NextBio | 779303 | |
| PRO | PR:Q27294 | |
| Proteomes | UP000000803 | |
| Bgee | Q27294 | |
| ExpressionAtlas | Q27294 | |
| GO | GO:0071013 GO:0005654 GO:0005634 GO:0003729 GO:0000166 GO:0008270 GO:0008344 GO:0048749 GO:0008345 GO:0000398 GO:0045887 GO:0051124 | |
| Gene3D | 3.30.70.330 4.10.1060.10 | |
| InterPro | IPR012677 IPR000504 IPR001876 | |
| Pfam | PF00076 PF00641 | |
| SMART | SM00360 SM00547 | |
| PROSITE | PS50102 PS01358 PS50199 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051124 |
synaptic growth at neuromuscular junction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045887 |
positive regulation of synaptic growth at neuromuscular junction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048749 |
compound eye development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008345 |
larval locomotory behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008344 |
adult locomotory behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008344 |
adult locomotory behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0071013 |
catalytic step 2 spliceosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000398 |
mRNA splicing, via spliceosome |
ECO:0000305 |
curator inference used in manual assertion |
GO:0071013 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003729 |
mRNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
Missing: with/from | |||
|
part_of |
GO:0005669 |
transcription factor TFIID complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
HGNC:11545 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006367 |
transcription initiation from RNA polymerase II promoter |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
HGNC:11545 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0035327 |
transcriptionally active chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Mallik, M et al. (2018) genetically interacts with the ALS-associated orthologue and mediates its toxicity. J. Cell Biol. 217 3947-3964 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Azuma, Y et al. (2014) Identification of ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS. Hum. Mol. Genet. 23 3467-80 PubMed GONUTS page
- ↑ Sasayama, H et al. (2012) Knockdown of the Drosophila fused in sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches. PLoS ONE 7 e39483 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Xia, R et al. (2012) Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS. Mol Neurodegener 7 10 PubMed GONUTS page
- ↑ 5.0 5.1 Wang, JW et al. (2011) The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span. J. Clin. Invest. 121 4118-26 PubMed GONUTS page
- ↑ 6.0 6.1 Herold, N et al. (2009) Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Mol. Cell. Biol. 29 281-301 PubMed GONUTS page
- ↑ Lasko, P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J. Cell Biol. 150 F51-6 PubMed GONUTS page
- ↑ 8.0 8.1 Aoyagi, N & Wassarman, DA (2000) Genes encoding Drosophila melanogaster RNA polymerase II general transcription factors: diversity in TFIIA and TFIID components contributes to gene-specific transcriptional regulation. J. Cell Biol. 150 F45-50 PubMed GONUTS page
- ↑ 9.0 9.1 Immanuel, D et al. (1995) Association of SARFH (sarcoma-associated RNA-binding fly homolog) with regions of chromatin transcribed by RNA polymerase II. Mol. Cell. Biol. 15 4562-71 PubMed GONUTS page
