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DROME:BGBP3

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) GNBP3 (ECO:0000312 with FlyBase:FBgn0040321)
Protein Name(s) Gram-negative bacteria-binding protein 3
External Links
UniProt Q9NHA8
EMBL AF228474
AM050231
AM050232
AM050233
AM050234
AM050235
AM050236
AM050237
AM050238
AM050239
AM050240
AM050241
AM050242
AE014296
RefSeq NP_523986.2
UniGene Dm.898
PDB 3IE4
PDBsum 3IE4
ProteinModelPortal Q9NHA8
SMR Q9NHA8
BioGrid 64425
IntAct Q9NHA8
MINT MINT-321664
CAZy CBM39
GH16
PaxDb Q9NHA8
PRIDE Q9NHA8
EnsemblMetazoa FBtr0076510
GeneID 39020
KEGG dme:Dmel_CG5008
CTD 39020
FlyBase FBgn0040321
eggNOG COG2273
GeneTree ENSGT00490000044173
InParanoid Q9NHA8
OMA LEWTPRE
OrthoDB EOG7HMS1G
PhylomeDB Q9NHA8
EvolutionaryTrace Q9NHA8
GenomeRNAi 39020
NextBio 811505
Proteomes UP000000803
Bgee Q9NHA8
ExpressionAtlas Q9NHA8
GO GO:0009986
GO:0005576
GO:0001872
GO:0004553
GO:0008329
GO:0005975
GO:0032491
GO:0045087
GO:0002758
GO:0002221
GO:0045088
GO:0009620
Gene3D 2.60.120.200
InterPro IPR013320
IPR000757
Pfam PF00722
SUPFAM SSF49899

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0002221

pattern recognition receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9NHB0

P

Seeded From UniProt

complete

involved_in

GO:0045088

regulation of innate immune response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9NHB0

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9NHB0

C

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040321
PANTHER:PTN002475215

C

Seeded From UniProt

complete

enables

GO:0008329

signaling pattern recognition receptor activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040323
PANTHER:PTN002475215

F

Seeded From UniProt

complete

enables

GO:0001872

(1->3)-beta-D-glucan binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040321
FB:FBgn0040322
FB:FBgn0040323
PANTHER:PTN002475215

F

Seeded From UniProt

complete

enables

GO:0001530

lipopolysaccharide binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040321
FB:FBgn0040322
FB:FBgn0040323
PANTHER:PTN002475215

F

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:19692333[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0001872

(1->3)-beta-D-glucan binding

PMID:19692333[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0032491

detection of molecule of fungal origin

PMID:19692333[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0001530

lipopolysaccharide binding

PMID:16385003[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001872

(1->3)-beta-D-glucan binding

PMID:16385003[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008329

signaling pattern recognition receptor activity

PMID:10827089[4]

ECO:0000250

sequence similarity evidence used in manual assertion

FB:FBgn0040323

F

Seeded From UniProt

complete

involved_in

GO:0002758

innate immune response-activating signal transduction

PMID:10827089[4]

ECO:0000250

sequence similarity evidence used in manual assertion

FB:FBgn0040323

P

Seeded From UniProt

complete

NOT|enables

GO:0052736

beta-glucanase activity

PMID:10827089[4]

ECO:0000320

phylogenetic determination of loss of key residues evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045752

positive regulation of Toll signaling pathway

PMID:18724373[5]

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0039494

P

Seeded From UniProt

complete

involved_in

GO:0045752

positive regulation of Toll signaling pathway

PMID:19590012[6]

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0051217

P

part_of:(GO:0050832)

Seeded From UniProt

complete

enables

GO:0004553

hydrolase activity, hydrolyzing O-glycosyl compounds

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000757

F

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000757

P

Seeded From UniProt

complete

enables

GO:0030246

carbohydrate binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031756

F

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Mishima, Y et al. (2009) The N-terminal domain of Drosophila Gram-negative binding protein 3 (GNBP3) defines a novel family of fungal pattern recognition receptors. J. Biol. Chem. 284 28687-97 PubMed GONUTS page
  3. ↑ 3.0 3.1 Lee, SH et al. (2006) Effects of solutes on solubilization and refolding of proteins from inclusion bodies with high hydrostatic pressure. Protein Sci. 15 304-13 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Kim, YS et al. (2000) Gram-negative bacteria-binding protein, a pattern recognition receptor for lipopolysaccharide and beta-1,3-glucan that mediates the signaling for the induction of innate immune genes in Drosophila melanogaster cells. J. Biol. Chem. 275 32721-7 PubMed GONUTS page
  5. ↑ El Chamy, L et al. (2008) Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll. Nat. Immunol. 9 1165-70 PubMed GONUTS page
  6. ↑ Buchon, N et al. (2009) A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway. Proc. Natl. Acad. Sci. U.S.A. 106 12442-7 PubMed GONUTS page
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