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DROME:BAM

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) bam
Protein Name(s) Protein bag-of-marbles
External Links
UniProt P22745
EMBL X56202
DQ315978
DQ315979
DQ315980
DQ315981
DQ315982
DQ315983
DQ315984
DQ315985
DQ315986
DQ315987
DQ315988
DQ315989
DQ315990
DQ315991
DQ315992
DQ315993
DQ315994
DQ315995
DQ315996
DQ315997
DQ315998
DQ315999
DQ316000
DQ316001
AE014297
AY119208
PIR A36469
RefSeq NP_476800.1
UniGene Dm.20252
BioGrid 67957
DIP DIP-48889N
PaxDb P22745
EnsemblMetazoa FBtr0084869
GeneID 43038
KEGG dme:Dmel_CG10422
CTD 43038
FlyBase FBgn0000158
eggNOG NOG255926
InParanoid P22745
OMA EANRHFD
OrthoDB EOG7DJSM8
PhylomeDB P22745
GenomeRNAi 43038
NextBio 831916
Proteomes UP000000803
Bgee P22745
ExpressionAtlas P22745
GO GO:0005737
GO:0045169
GO:0045170
GO:0003730
GO:0000900
GO:0001709
GO:0001708
GO:0007282
GO:0048135
GO:0048132
GO:0045478
GO:0007276
GO:0007281
GO:0042078
GO:0030718
GO:0030727
GO:0007140
GO:0007275
GO:0017148
GO:0048477
GO:0030721
GO:0007283
GO:0007284
GO:0045479

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000900

translation repressor activity, nucleic acid binding

PMID:19556547[1]

IDA: Inferred from Direct Assay

F

complete

GO:0001708

cell fate specification

PMID:9813190[2]

TAS: Traceable Author Statement

P

complete

GO:0000900

translation repressor activity, nucleic acid binding

PMID:19556547[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0001709

cell fate determination

PMID:11131529[3]

TAS: Traceable Author Statement

P

complete

GO:0001708

cell fate specification

PMID:9813190[2]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:7555720[4]

IDA: Inferred from Direct Assay

C

complete

GO:0001709

cell fate determination

PMID:11131529[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:9813190[2]

TAS: Traceable Author Statement

C

complete

GO:0003730

mRNA 3'-UTR binding

PMID:23122292[5]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0007049

cell cycle

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0131

P

complete

GO:0005737

cytoplasm

PMID:25412508[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007140

male meiosis

PMID:9813190[2]

TAS: Traceable Author Statement

P

complete

GO:0005737

cytoplasm

PMID:7555720[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0217

P

complete

GO:0005737

cytoplasm

PMID:9813190[2]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0007276

gamete generation

PMID:2279698[7]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0007049

cell cycle

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

GO:0007140

male meiosis

PMID:9813190[2]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007281

germ cell development

PMID:11131529[3]

TAS: Traceable Author Statement

P

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007281

germ cell development

PMID:9813190[2]

TAS: Traceable Author Statement

P

complete

GO:0007276

gamete generation

PMID:2279698[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007282

cystoblast division

PMID:11131529[3]

TAS: Traceable Author Statement

P

complete

GO:0007281

germ cell development

PMID:11131529[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007282

cystoblast division

PMID:7555720[4]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0007281

germ cell development

PMID:9813190[2]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007282

cystoblast division

PMID:8970731[8]

TAS: Traceable Author Statement

P

complete

GO:0007282

cystoblast division

PMID:11131529[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007283

spermatogenesis

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0744

P

complete

GO:0007282

cystoblast division

PMID:7555720[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007283

spermatogenesis

PMID:7555720[4]

TAS: Traceable Author Statement

P

complete

GO:0007282

cystoblast division

PMID:8970731[8]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007283

spermatogenesis

PMID:9813190[2]

TAS: Traceable Author Statement

P

complete

GO:0007283

spermatogenesis

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0744

P

Seeded From UniProt

complete

GO:0007284

spermatogonial cell division

PMID:11131529[3]

TAS: Traceable Author Statement

P

complete

GO:0007283

spermatogenesis

PMID:7555720[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007284

spermatogonial cell division

PMID:20018708[9]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0007283

spermatogenesis

PMID:9813190[2]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0030154

cell differentiation

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0221

P

complete

GO:0007284

spermatogonial cell division

PMID:11131529[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0030721

spectrosome organization

PMID:11131529[3]

TAS: Traceable Author Statement

P

complete

GO:0007284

spermatogonial cell division

PMID:20018708[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030727

germarium-derived female germ-line cyst formation

PMID:16280348[10]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0017148

negative regulation of translation

PMID:25412508[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042078

germ-line stem cell division

PMID:11131529[3]

TAS: Traceable Author Statement

P

complete

GO:0030154

cell differentiation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

GO:0042078

germ-line stem cell division

PMID:15927177[11]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0030718

germ-line stem cell maintenance

PMID:19470484[12]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045169

fusome

PMID:11131529[3]

TAS: Traceable Author Statement

C

complete

GO:0030721

spectrosome organization

PMID:11131529[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0045169

fusome

PMID:7555720[4]

IDA: Inferred from Direct Assay

C

complete

GO:0030727

germarium-derived female germ-line cyst formation

PMID:16280348[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045169

fusome

PMID:9813190[2]

TAS: Traceable Author Statement

C

complete

GO:0035212

cell competition in a multicellular organism

PMID:18371420[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045170

spectrosome

PMID:11131529[3]

TAS: Traceable Author Statement

C

complete

GO:0042078

germ-line stem cell division

PMID:11131529[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0045170

spectrosome

PMID:7555720[4]

IDA: Inferred from Direct Assay

C

complete

GO:0042078

germ-line stem cell division

PMID:15927177[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045478

fusome organization

PMID:7555720[4]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0045169

fusome

PMID:11131529[3]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0045479

vesicle targeting to fusome

PMID:11131529[3]

TAS: Traceable Author Statement

P

complete

GO:0045169

fusome

PMID:7555720[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0048132

female germ-line stem cell division

PMID:19556547[1]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0048135

female germ-line cyst formation

PMID:10370240[14]

TAS: Traceable Author Statement

P

complete

GO:0045169

fusome

PMID:9813190[2]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0048477

oogenesis

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0896

P

complete

GO:0045170

spectrosome

PMID:11131529[3]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:19556547[1]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0045170

spectrosome

PMID:7555720[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:7555720[4]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0045478

fusome organization

PMID:7555720[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045479

vesicle targeting to fusome

PMID:11131529[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0048132

female germ-line stem cell asymmetric division

PMID:19556547[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048135

female germ-line cyst formation

PMID:10370240[14]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0048477

oogenesis

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0896

P

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:19556547[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:7555720[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0098730

male germline stem cell symmetric division

PMID:18371420[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Shen, R et al. (2009) eIF4A controls germline stem cell self-renewal by directly inhibiting BAM function in the Drosophila ovary. Proc. Natl. Acad. Sci. U.S.A. 106 11623-8 PubMed GONUTS page
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 Fuller, MT (1998) Genetic control of cell proliferation and differentiation in Drosophila spermatogenesis. Semin. Cell Dev. Biol. 9 433-44 PubMed GONUTS page
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 Deng, W & Lin, H (2001) Asymmetric germ cell division and oocyte determination during Drosophila oogenesis. Int. Rev. Cytol. 203 93-138 PubMed GONUTS page
  4. 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 McKearin, D & Ohlstein, B (1995) A role for the Drosophila bag-of-marbles protein in the differentiation of cystoblasts from germline stem cells. Development 121 2937-47 PubMed GONUTS page
  5. Insco, ML et al. (2012) A self-limiting switch based on translational control regulates the transition from proliferation to differentiation in an adult stem cell lineage. Cell Stem Cell 11 689-700 PubMed GONUTS page
  6. 6.0 6.1 Chen, D et al. (2014) Three RNA binding proteins form a complex to promote differentiation of germline stem cell lineage in Drosophila. PLoS Genet. 10 e1004797 PubMed GONUTS page
  7. 7.0 7.1 McKearin, DM & Spradling, AC (1990) bag-of-marbles: a Drosophila gene required to initiate both male and female gametogenesis. Genes Dev. 4 2242-51 PubMed GONUTS page
  8. 8.0 8.1 Williamson, A & Lehmann, R (1996) Germ cell development in Drosophila. Annu. Rev. Cell Dev. Biol. 12 365-91 PubMed GONUTS page
  9. 9.0 9.1 Insco, ML et al. (2009) Accumulation of a differentiation regulator specifies transit amplifying division number in an adult stem cell lineage. Proc. Natl. Acad. Sci. U.S.A. 106 22311-6 PubMed GONUTS page
  10. 10.0 10.1 Xi, R et al. (2005) Pelota controls self-renewal of germline stem cells by repressing a Bam-independent differentiation pathway. Development 132 5365-74 PubMed GONUTS page
  11. 11.0 11.1 Kai, T et al. (2005) The expression profile of purified Drosophila germline stem cells. Dev. Biol. 283 486-502 PubMed GONUTS page
  12. Li, Y et al. (2009) Bam and Bgcn antagonize Nanos-dependent germ-line stem cell maintenance. Proc. Natl. Acad. Sci. U.S.A. 106 9304-9 PubMed GONUTS page
  13. 13.0 13.1 Jin, Z et al. (2008) Differentiation-defective stem cells outcompete normal stem cells for niche occupancy in the Drosophila ovary. Cell Stem Cell 2 39-49 PubMed GONUTS page
  14. 14.0 14.1 Pepling, ME et al. (1999) Germline cysts: a conserved phase of germ cell development? Trends Cell Biol. 9 257-62 PubMed GONUTS page