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DROME:ACE

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Ance (synonyms: Race)
Protein Name(s) Angiotensin-converting enzyme

Dipeptidyl carboxypeptidase I Kininase II

External Links
UniProt Q10714
EMBL U25344
U34599
AE014134
AE014134
AY061129
RefSeq NP_001285915.1
NP_477046.1
NP_723852.1
UniGene Dm.2157
PDB 1J36
1J37
1J38
2X8Y
2X8Z
2X90
2X91
2X92
2X93
2X94
2X95
2X96
2X97
2XHM
3ZQZ
4AA1
4AA2
4ASQ
4ASR
4CA7
4CA8
PDBsum 1J36
1J37
1J38
2X8Y
2X8Z
2X90
2X91
2X92
2X93
2X94
2X95
2X96
2X97
2XHM
3ZQZ
4AA1
4AA2
4ASQ
4ASR
4CA7
4CA8
ProteinModelPortal Q10714
SMR Q10714
BioGrid 60835
IntAct Q10714
MINT MINT-808657
MEROPS M02.003
PaxDb Q10714
PRIDE Q10714
EnsemblMetazoa FBtr0080552
FBtr0080553
GeneID 34805
KEGG dme:Dmel_CG8827
CTD 34805
FlyBase FBgn0012037
eggNOG NOG71044
GeneTree ENSGT00520000055576
InParanoid Q10714
KO K01283
OMA PFAYLMD
OrthoDB EOG76HQ13
PhylomeDB Q10714
SABIO-RK Q10714
EvolutionaryTrace Q10714
GenomeRNAi 34805
NextBio 790306
Proteomes UP000000803
Bgee Q10714
GO GO:0005615
GO:0016020
GO:0004180
GO:0046872
GO:0008237
GO:0008241
GO:0007552
GO:0006508
GO:0009609
GO:0007291
GO:0007289
InterPro IPR001548
PANTHER PTHR10514
Pfam PF01401
PRINTS PR00791
PROSITE PS00142

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004180

carboxypeptidase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0121

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:23082758[1]

IPI: Inferred from Physical Interaction

UniProtKB:P01019

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:23082758[1]

IPI: Inferred from Physical Interaction

UniProtKB:P01042

F

Seeded From UniProt

complete

GO:0005576

extracellular region

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

GO:0005615

extracellular space

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0112

C

Seeded From UniProt

complete

GO:0005615

extracellular space

PMID:17921161[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006508

proteolysis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001548

P

Seeded From UniProt

complete

GO:0006508

proteolysis

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

GO:0006508

proteolysis

PMID:17921161[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007289

spermatid nucleus differentiation

PMID:12591244[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007291

sperm individualization

PMID:12591244[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007552

metamorphosis

PMID:12093364[4]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0008233

peptidase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

GO:0008237

metallopeptidase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001548

F

Seeded From UniProt

complete

GO:0008237

metallopeptidase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0482

F

Seeded From UniProt

complete

GO:0008241

peptidyl-dipeptidase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001548

F

Seeded From UniProt

complete

GO:0008241

peptidyl-dipeptidase activity

PMID:10913309[5]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0008241

peptidyl-dipeptidase activity

PMID:17921161[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0008241

peptidyl-dipeptidase activity

PMID:7775412[6]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0009609

response to symbiotic bacterium

PMID:18171476[7]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0009609

response to symbiotic bacterium

PMID:18171476[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001548

C

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Akif, M et al. (2012) Structural basis of peptide recognition by the angiotensin-1 converting enzyme homologue AnCE from Drosophila melanogaster. FEBS J. 279 4525-34 PubMed GONUTS page
  2. 2.0 2.1 2.2 Rylett, CM et al. (2007) Male accessory glands of Drosophila melanogaster make a secreted angiotensin I-converting enzyme (ANCE), suggesting a role for the peptide-processing enzyme in seminal fluid. J. Exp. Biol. 210 3601-6 PubMed GONUTS page
  3. 3.0 3.1 Hurst, D et al. (2003) The drosophila angiotensin-converting enzyme homologue Ance is required for spermiogenesis. Dev. Biol. 254 238-47 PubMed GONUTS page
  4. Siviter, RJ et al. (2002) Ance, a Drosophila angiotensin-converting enzyme homologue, is expressed in imaginal cells during metamorphosis and is regulated by the steroid, 20-hydroxyecdysone. Biochem. J. 367 187-93 PubMed GONUTS page
  5. Coates, D et al. (2000) Functional conservation of the active sites of human and Drosophila angiotensin I-converting enzyme. Biochemistry 39 8963-9 PubMed GONUTS page
  6. Cornell, MJ et al. (1995) Cloning and expression of an evolutionary conserved single-domain angiotensin converting enzyme from Drosophila melanogaster. J. Biol. Chem. 270 13613-9 PubMed GONUTS page
  7. 7.0 7.1 Xi, Z et al. (2008) Genome-wide analysis of the interaction between the endosymbiotic bacterium Wolbachia and its Drosophila host. BMC Genomics 9 1 PubMed GONUTS page