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DROME:A1Z9N0

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Opa1 (ECO:0000313 with FlyBase:FBgn0261276)
Protein Name(s) Optic atrophy 1-like, isoform A (ECO:0000313 with EMBL:AAF58275.2)
External Links
UniProt A1Z9N0
EMBL AE013599
RefSeq NP_725369.1
UniGene Dm.7707
ProteinModelPortal A1Z9N0
SMR A1Z9N0
STRING 7227.FBpp0086700
PaxDb A1Z9N0
PRIDE A1Z9N0
EnsemblMetazoa FBtr0087574
GeneID 36578
KEGG dme:Dmel_CG8479
UCSC CG8479-RA
CTD 4976
FlyBase FBgn0261276
eggNOG COG0699
GeneTree ENSGT00550000074851
InParanoid A1Z9N0
KO K17079
OMA KRHKWNE
OrthoDB EOG7TMZR4
PhylomeDB A1Z9N0
GenomeRNAi 36578
NextBio 799304
PRO PR:A1Z9N0
Proteomes UP000000803
Bgee A1Z9N0
ExpressionAtlas A1Z9N0
GO GO:0005739
GO:0005525
GO:0003924
GO:0001745
GO:0006184
GO:0008053
GO:0070584
GO:0007005
GO:1902236
GO:0010636
Gene3D 3.40.50.300
InterPro IPR001401
IPR022812
IPR030381
IPR027417
PANTHER PTHR11566
PRINTS PR00195
SMART SM00053
SUPFAM SSF52540
PROSITE PS51718

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0001745

compound eye morphogenesis

PMID:18193945[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003924

GTPase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001401

F

Seeded From UniProt

complete

GO:0003924

GTPase activity

PMID:18193945[1]

ISM: Inferred from Sequence Model

F

Seeded From UniProt

Missing: with/from

GO:0005525

GTP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001401
InterPro:IPR030381

F

Seeded From UniProt

complete

GO:0005525

GTP binding

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

GO:0005739

mitochondrion

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O60313

C

Seeded From UniProt

complete

GO:0005739

mitochondrion

PMID:18193945[1]

ISS: Inferred from Sequence or Structural Similarity

HGNC:8140

C

Seeded From UniProt

complete

GO:0005739

mitochondrion

PMID:24998521[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007005

mitochondrion organization

PMID:18799731[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008053

mitochondrial fusion

PMID:16713954[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001401

P

Seeded From UniProt

complete

GO:0010636

positive regulation of mitochondrial fusion

PMID:20194754[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0070584

mitochondrion morphogenesis

PMID:18193945[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0070584

mitochondrion morphogenesis

PMID:24998521[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O60313

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Yarosh, W et al. (2008) The molecular mechanisms of OPA1-mediated optic atrophy in Drosophila model and prospects for antioxidant treatment. PLoS Genet. 4 e6 PubMed GONUTS page
  2. 2.0 2.1 Banerjee, S & Chinthapalli, B (2014) A proteomic screen with Drosophila Opa1-like identifies Hsc70-5/Mortalin as a regulator of mitochondrial morphology and cellular homeostasis. Int. J. Biochem. Cell Biol. 54 36-48 PubMed GONUTS page
  3. Deng, H et al. (2008) The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 105 14503-8 PubMed GONUTS page
  4. McQuibban, GA et al. (2006) Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function. Curr. Biol. 16 982-9 PubMed GONUTS page
  5. Ziviani, E et al. (2010) Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc. Natl. Acad. Sci. U.S.A. 107 5018-23 PubMed GONUTS page