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DROME:A1Z9N0

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Opa1 (ECO:0000313 with FlyBase:FBgn0261276)
Protein Name(s) Optic atrophy 1-like, isoform A (ECO:0000313 with EMBL:AAF58275.2)
External Links
UniProt A1Z9N0
EMBL AE013599
RefSeq NP_725369.1
UniGene Dm.7707
ProteinModelPortal A1Z9N0
SMR A1Z9N0
STRING 7227.FBpp0086700
PaxDb A1Z9N0
PRIDE A1Z9N0
EnsemblMetazoa FBtr0087574
GeneID 36578
KEGG dme:Dmel_CG8479
UCSC CG8479-RA
CTD 4976
FlyBase FBgn0261276
eggNOG COG0699
GeneTree ENSGT00550000074851
InParanoid A1Z9N0
KO K17079
OMA KRHKWNE
OrthoDB EOG7TMZR4
PhylomeDB A1Z9N0
GenomeRNAi 36578
NextBio 799304
PRO PR:A1Z9N0
Proteomes UP000000803
Bgee A1Z9N0
ExpressionAtlas A1Z9N0
GO GO:0005739
GO:0005525
GO:0003924
GO:0001745
GO:0006184
GO:0008053
GO:0070584
GO:0007005
GO:1902236
GO:0010636
Gene3D 3.40.50.300
InterPro IPR001401
IPR022812
IPR030381
IPR027417
PANTHER PTHR11566
PRINTS PR00195
SMART SM00053
SUPFAM SSF52540
PROSITE PS51718

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005739

mitochondrion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O60313

C

Seeded From UniProt

complete

involved_in

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O60313

P

Seeded From UniProt

complete

involved_in

GO:0061025

membrane fusion

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000170085
UniProtKB:O00429

P

Seeded From UniProt

complete

part_of

GO:0031966

mitochondrial membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000170085
RGD:620416

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000170013
TAIR:locus:2006777
TAIR:locus:2012763
UniProtKB:Q8S944

C

Seeded From UniProt

complete

enables

GO:0008017

microtubule binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003392
PANTHER:PTN000170013

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261276
MGI:MGI:1921393
PANTHER:PTN002480282
RGD:708423
UniProtKB:O60313
WB:WBGene00001134

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003392
MGI:MGI:1921256
PANTHER:PTN000170013
PomBase:SPBC12C2.08
RGD:2513
RGD:628821
RGD:71096
RGD:727949
TAIR:locus:2006777
UniProtKB:K7GKN2
UniProtKB:O00429
UniProtKB:P20591
UniProtKB:P27594
UniProtKB:P79135
UniProtKB:Q8IHR4
dictyBase:DDB_G0277849
dictyBase:DDB_G0277851

C

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000170013
RGD:2513
RGD:727949
SGD:S000001709
SGD:S000003924
UniProtKB:K7GKN2
UniProtKB:O00429
UniProtKB:O60313
UniProtKB:P27594
UniProtKB:P42697
UniProtKB:Q8S944
WB:WBGene00001130
dictyBase:DDB_G0277849

F

Seeded From UniProt

complete

involved_in

GO:0003374

dynamin family protein polymerization involved in mitochondrial fission

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000170085
UniProtKB:O00429

P

Seeded From UniProt

complete

involved_in

GO:0000266

mitochondrial fission

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0026479
MGI:MGI:1921256
PANTHER:PTN000902162
SGD:S000003924
TAIR:locus:2006777
UniProtKB:O00429
UniProtKB:Q8LFT2
UniProtKB:Q8S944
WB:WBGene00001093

P

Seeded From UniProt

complete

involved_in

GO:0070584

mitochondrion morphogenesis

PMID:24998521[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:24998521[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010636

positive regulation of mitochondrial fusion

PMID:20194754[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007005

mitochondrion organization

PMID:18799731[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070584

mitochondrion morphogenesis

PMID:18193945[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001745

compound eye morphogenesis

PMID:18193945[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:18193945[5]

ECO:0000250

sequence similarity evidence used in manual assertion

HGNC:8140

C

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

PMID:18193945[5]

ECO:0000255

match to sequence model evidence used in manual assertion

F

Seeded From UniProt

Missing: with/from

involved_in

GO:0008053

mitochondrial fusion

PMID:16713954[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001401
InterPro:IPR033047

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001401
InterPro:IPR030381

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033047

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033047

P

Seeded From UniProt

complete

involved_in

GO:0007005

mitochondrion organization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033047

P

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ 2.0 2.1 Banerjee, S & Chinthapalli, B (2014) A proteomic screen with Drosophila Opa1-like identifies Hsc70-5/Mortalin as a regulator of mitochondrial morphology and cellular homeostasis. Int. J. Biochem. Cell Biol. 54 36-48 PubMed GONUTS page
  3. ↑ Ziviani, E et al. (2010) Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc. Natl. Acad. Sci. U.S.A. 107 5018-23 PubMed GONUTS page
  4. ↑ Deng, H et al. (2008) The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 105 14503-8 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Yarosh, W et al. (2008) The molecular mechanisms of OPA1-mediated optic atrophy in Drosophila model and prospects for antioxidant treatment. PLoS Genet. 4 e6 PubMed GONUTS page
  6. ↑ McQuibban, GA et al. (2006) Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function. Curr. Biol. 16 982-9 PubMed GONUTS page
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