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DROME:A1Z6P3

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) No Information Provided. (synonyms: Eb1-RF (ECO:0000313 with EMBL:ACY79584.1))
Protein Name(s) Eb1, isoform F (ECO:0000313 with EMBL:AAM70825.2)

FI12926p (ECO:0000313 with EMBL:ACY79584.1)

External Links
UniProt A1Z6P3
EMBL AE013599
BT100289
RefSeq NP_724495.2
UniGene Dm.5955
SMR A1Z6P3
STRING 7227.FBpp0289513
EnsemblMetazoa FBtr0300285
GeneID 35584
KEGG dme:Dmel_CG3265
CTD 35584
FlyBase FBgn0027066
eggNOG COG5217
GeneTree ENSGT00490000043329
KO K10436
OMA CQEVDET
OrthoDB EOG7ZD1W5
PhylomeDB A1Z6P3
GenomeRNAi 35584
NextBio 794143
PRO PR:A1Z6P3
Proteomes UP000000803
GO GO:0005737
GO:0005874
GO:0005875
GO:0008017
GO:0017022
GO:0007059
GO:0040001
GO:0030951
GO:0007629
GO:0007626
GO:0035011
GO:0000226
GO:0007017
GO:0000022
GO:0007052
GO:0030589
GO:0007423
GO:0007605
GO:0051225
GO:0042060
Gene3D 1.10.418.10
InterPro IPR001715
IPR004953
IPR027328
PANTHER PTHR10623
Pfam PF00307
PF03271
SUPFAM SSF140612
SSF47576
PROSITE PS51230

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000022

mitotic spindle elongation

PMID:12213835[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0000022

mitotic spindle elongation

PMID:16303556[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0000022

mitotic spindle elongation

PMID:17412918[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0000226

microtubule cytoskeleton organization

PMID:21646401[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12842007[5]

IPI: Inferred from Physical Interaction

UniProtKB:O77291

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19279137[6]

IPI: Inferred from Physical Interaction

FB:FBgn0011202

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:15591130[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005874

microtubule

PMID:12213835[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005874

microtubule

PMID:15699215[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005875

microtubule associated complex

PMID:10908588[9]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0005875

microtubule associated complex

PMID:11700298[10]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005875

microtubule associated complex

PMID:18433294[11]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007017

microtubule-based process

PMID:10908588[9]

ISS: Inferred from Sequence or Structural Similarity

P

Seeded From UniProt

Missing: with/from

GO:0007017

microtubule-based process

PMID:12867052[12]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007052

mitotic spindle organization

PMID:12867052[12]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007059

chromosome segregation

PMID:12213835[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007423

sensory organ development

PMID:15591130[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007605

sensory perception of sound

PMID:15591130[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007626

locomotory behavior

PMID:15591130[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007629

flight behavior

PMID:15591130[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008017

microtubule binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004953
InterPro:IPR027328

F

Seeded From UniProt

complete

GO:0008017

microtubule binding

PMID:10908588[9]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0008017

microtubule binding

PMID:12867052[12]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0017022

myosin binding

PMID:18045836[13]

IPI: Inferred from Physical Interaction

FB:FBgn0263705

F

Seeded From UniProt

complete

GO:0030589

pseudocleavage involved in syncytial blastoderm formation

PMID:19279137[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030951

establishment or maintenance of microtubule cytoskeleton polarity

PMID:21145742[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035011

melanotic encapsulation of foreign target

PMID:21947570[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0040001

establishment of mitotic spindle localization

PMID:12867052[12]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0042060

wound healing

PMID:23038780[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051225

spindle assembly

PMID:12213835[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

colocalizes_with

GO:0005876

spindle microtubule

PMID:15591130[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

colocalizes_with

GO:0005881

cytoplasmic microtubule

PMID:15591130[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

colocalizes_with

GO:0035371

microtubule plus-end

PMID:16105886[17]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Rogers, SL et al. (2002) Drosophila EB1 is important for proper assembly, dynamics, and positioning of the mitotic spindle. J. Cell Biol. 158 873-84 PubMed GONUTS page
  2. Goshima, G et al. (2005) Length control of the metaphase spindle. Curr. Biol. 15 1979-88 PubMed GONUTS page
  3. Goshima, G et al. (2007) Genes required for mitotic spindle assembly in Drosophila S2 cells. Science 316 417-21 PubMed GONUTS page
  4. Li, W et al. (2011) EB1 promotes microtubule dynamics by recruiting Sentin in Drosophila cells. J. Cell Biol. 193 973-83 PubMed GONUTS page
  5. Subramanian, A et al. (2003) Shortstop recruits EB1/APC1 and promotes microtubule assembly at the muscle-tendon junction. Curr. Biol. 13 1086-95 PubMed GONUTS page
  6. 6.0 6.1 Webb, RL et al. (2009) A novel role for an APC2-Diaphanous complex in regulating actin organization in Drosophila. Development 136 1283-93 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Elliott, SL et al. (2005) EB1 is essential during Drosophila development and plays a crucial role in the integrity of chordotonal mechanosensory organs. Mol. Biol. Cell 16 891-901 PubMed GONUTS page
  8. Slep, KC et al. (2005) Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end. J. Cell Biol. 168 587-98 PubMed GONUTS page
  9. 9.0 9.1 9.2 Goldstein, LS & Gunawardena, S (2000) Flying through the drosophila cytoskeletal genome. J. Cell Biol. 150 F63-8 PubMed GONUTS page
  10. Tepass, U et al. (2001) Epithelial cell polarity and cell junctions in Drosophila. Annu. Rev. Genet. 35 747-84 PubMed GONUTS page
  11. Hughes, JR et al. (2008) A microtubule interactome: complexes with roles in cell cycle and mitosis. PLoS Biol. 6 e98 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 Grevengoed, EE & Peifer, M (2003) Cytoskeletal connections: building strong cells in new ways. Curr. Biol. 13 R568-70 PubMed GONUTS page
  13. Liu, R et al. (2008) Sisyphus, the Drosophila myosin XV homolog, traffics within filopodia transporting key sensory and adhesion cargos. Development 135 53-63 PubMed GONUTS page
  14. Mattie, FJ et al. (2010) Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendrites. Curr. Biol. 20 2169-77 PubMed GONUTS page
  15. Howell, L et al. (2012) A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response. Immunogenetics 64 155-61 PubMed GONUTS page
  16. Abreu-Blanco, MT et al. (2012) Drosophila embryos close epithelial wounds using a combination of cellular protrusions and an actomyosin purse string. J. Cell. Sci. 125 5984-97 PubMed GONUTS page
  17. Dzhindzhev, NS et al. (2005) Distinct mechanisms govern the localisation of Drosophila CLIP-190 to unattached kinetochores and microtubule plus-ends. J. Cell. Sci. 118 3781-90 PubMed GONUTS page