DROME:A1Z6P3

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	No Information Provided. (synonyms: Eb1-RF (ECO:0000313 with EMBL:ACY79584.1))
Protein Name(s)	Eb1, isoform F (ECO:0000313 with EMBL:AAM70825.2) FI12926p (ECO:0000313 with EMBL:ACY79584.1)
External Links
UniProt	A1Z6P3
EMBL	AE013599 BT100289
RefSeq	NP_724495.2
UniGene	Dm.5955
SMR	A1Z6P3
STRING	7227.FBpp0289513
EnsemblMetazoa	FBtr0300285
GeneID	35584
KEGG	dme:Dmel_CG3265
CTD	35584
FlyBase	FBgn0027066
eggNOG	COG5217
GeneTree	ENSGT00490000043329
KO	K10436
OMA	CQEVDET
OrthoDB	EOG7ZD1W5
PhylomeDB	A1Z6P3
GenomeRNAi	35584
NextBio	794143
PRO	PR:A1Z6P3
Proteomes	UP000000803
GO	GO:0005737 GO:0005874 GO:0005875 GO:0008017 GO:0017022 GO:0007059 GO:0040001 GO:0030951 GO:0007629 GO:0007626 GO:0035011 GO:0000226 GO:0007017 GO:0000022 GO:0007052 GO:0030589 GO:0007423 GO:0007605 GO:0051225 GO:0042060
Gene3D	1.10.418.10
InterPro	IPR001715 IPR004953 IPR027328
PANTHER	PTHR10623
Pfam	PF00307 PF03271
SUPFAM	SSF140612 SSF47576
PROSITE	PS51230

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:1904825	protein localization to microtubule plus-end	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000065701 PomBase:SPAC18G6.15	P	Seeded From UniProt	complete
part_of	GO:0051233	spindle midzone	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000065701 SGD:S000000818	C	Seeded From UniProt	complete
involved_in	GO:0051225	spindle assembly	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0027066 PANTHER:PTN000065701 dictyBase:DDB_G0283607	P	Seeded From UniProt	complete
enables	GO:0051010	microtubule plus-end binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000065701 PomBase:SPAC18G6.15 RGD:621781 SGD:S000000818 UniProtKB:Q15691	F	Seeded From UniProt	complete
involved_in	GO:0035372	protein localization to microtubule	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:891995 PANTHER:PTN000065701 PomBase:SPAC18G6.15 UniProtKB:Q15691	P	Seeded From UniProt	complete
part_of	GO:0035371	microtubule plus-end	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0027066 MGI:MGI:106271 MGI:MGI:2140967 MGI:MGI:891995 PANTHER:PTN000065701 SGD:S000000818 WB:WBGene00012156 WB:WBGene00013344	C	Seeded From UniProt	complete
involved_in	GO:0031110	regulation of microtubule polymerization or depolymerization	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000065701 PomBase:SPAC18G6.15	P	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2140967 PANTHER:PTN000065701 PomBase:SPAC18G6.15 TAIR:locus:2100417 dictyBase:DDB_G0283607	F	Seeded From UniProt	complete
part_of	GO:0005881	cytoplasmic microtubule	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0027066 MGI:MGI:891995 PANTHER:PTN000065701 PomBase:SPAC18G6.15 SGD:S000000818 UniProtKB:Q9UPY8	C	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0027066 MGI:MGI:2140967 MGI:MGI:891995 PANTHER:PTN000065701 TAIR:locus:2154149 UniProtKB:Q15691 WB:WBGene00012156 dictyBase:DDB_G0283607	C	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000065701 TAIR:locus:2100417 TAIR:locus:2154149	C	Seeded From UniProt	complete
part_of	GO:0005875	microtubule associated complex	PMID:10908588^[2]	ECO:0000250	sequence similarity evidence used in manual assertion		C	Seeded From UniProt	Missing: with/from
part_of	GO:0044295	axonal growth cone	PMID:27605706^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	PMID:23038780^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035011	melanotic encapsulation of foreign target	PMID:21947570^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	PMID:21646401^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	PMID:21145742^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030589	pseudocleavage involved in syncytial blastoderm formation	PMID:19279137^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0017022	myosin binding	PMID:18045836^[9]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0263705	F	Seeded From UniProt	complete
involved_in	GO:0000022	mitotic spindle elongation	PMID:16303556^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0035371	microtubule plus-end	PMID:16105886^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	PMID:15699215^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	PMID:15591130^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007423	sensory organ development	PMID:15591130^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0005881	cytoplasmic microtubule	PMID:15591130^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15591130^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007629	flight behavior	PMID:15591130^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	PMID:15591130^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0005876	spindle microtubule	PMID:15591130^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007059	chromosome segregation	PMID:12213835^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051225	spindle assembly	PMID:12213835^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000022	mitotic spindle elongation	PMID:12213835^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	PMID:12213835^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:10908588^[2]	ECO:0000250	sequence similarity evidence used in manual assertion		F	Seeded From UniProt	Missing: with/from
involved_in	GO:0007017	microtubule-based process	PMID:10908588^[2]	ECO:0000250	sequence similarity evidence used in manual assertion		P	Seeded From UniProt	Missing: with/from
enables	GO:0008017	microtubule binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004953 InterPro:IPR027328 InterPro:IPR036133	F	Seeded From UniProt	complete
enables	GO:0051010	microtubule plus-end binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027739	F	Seeded From UniProt	complete
involved_in	GO:0070507	regulation of microtubule cytoskeleton organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027739	P	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:12867052^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007052	mitotic spindle organization	PMID:12867052^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0040001	establishment of mitotic spindle localization	PMID:12867052^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007017	microtubule-based process	PMID:12867052^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005875	microtubule associated complex	PMID:11700298^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Goldstein, LS & Gunawardena, S (2000) Flying through the drosophila cytoskeletal genome. J. Cell Biol. 150 F63-8 PubMed GONUTS page
↑ Rao, K et al. (2016) Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration. Mol. Biol. Cell 27 3245-3256 PubMed GONUTS page
↑ Abreu-Blanco, MT et al. (2012) Drosophila embryos close epithelial wounds using a combination of cellular protrusions and an actomyosin purse string. J. Cell. Sci. 125 5984-97 PubMed GONUTS page
↑ Howell, L et al. (2012) A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response. Immunogenetics 64 155-61 PubMed GONUTS page
↑ Li, W et al. (2011) EB1 promotes microtubule dynamics by recruiting Sentin in Drosophila cells. J. Cell Biol. 193 973-83 PubMed GONUTS page
↑ Mattie, FJ et al. (2010) Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendrites. Curr. Biol. 20 2169-77 PubMed GONUTS page
↑ Webb, RL et al. (2009) A novel role for an APC2-Diaphanous complex in regulating actin organization in Drosophila. Development 136 1283-93 PubMed GONUTS page
↑ Liu, R et al. (2008) Sisyphus, the Drosophila myosin XV homolog, traffics within filopodia transporting key sensory and adhesion cargos. Development 135 53-63 PubMed GONUTS page
↑ Goshima, G et al. (2005) Length control of the metaphase spindle. Curr. Biol. 15 1979-88 PubMed GONUTS page
↑ Dzhindzhev, NS et al. (2005) Distinct mechanisms govern the localisation of Drosophila CLIP-190 to unattached kinetochores and microtubule plus-ends. J. Cell. Sci. 118 3781-90 PubMed GONUTS page
↑ Slep, KC et al. (2005) Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end. J. Cell Biol. 168 587-98 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Elliott, SL et al. (2005) EB1 is essential during Drosophila development and plays a crucial role in the integrity of chordotonal mechanosensory organs. Mol. Biol. Cell 16 891-901 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Rogers, SL et al. (2002) Drosophila EB1 is important for proper assembly, dynamics, and positioning of the mitotic spindle. J. Cell Biol. 158 873-84 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Grevengoed, EE & Peifer, M (2003) Cytoskeletal connections: building strong cells in new ways. Curr. Biol. 13 R568-70 PubMed GONUTS page
↑ Tepass, U et al. (2001) Epithelial cell polarity and cell junctions in Drosophila. Annu. Rev. Genet. 35 747-84 PubMed GONUTS page

[PMID:21873635-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10908588-2] 2.0 ^2.1 ^2.2 Goldstein, LS & Gunawardena, S (2000) Flying through the drosophila cytoskeletal genome. J. Cell Biol. 150 F63-8 PubMed GONUTS page

[PMID:27605706-3] Rao, K et al. (2016) Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration. Mol. Biol. Cell 27 3245-3256 PubMed GONUTS page

[PMID:23038780-4] Abreu-Blanco, MT et al. (2012) Drosophila embryos close epithelial wounds using a combination of cellular protrusions and an actomyosin purse string. J. Cell. Sci. 125 5984-97 PubMed GONUTS page

[PMID:21947570-5] Howell, L et al. (2012) A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response. Immunogenetics 64 155-61 PubMed GONUTS page

[PMID:21646401-6] Li, W et al. (2011) EB1 promotes microtubule dynamics by recruiting Sentin in Drosophila cells. J. Cell Biol. 193 973-83 PubMed GONUTS page

[PMID:21145742-7] Mattie, FJ et al. (2010) Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendrites. Curr. Biol. 20 2169-77 PubMed GONUTS page

[PMID:19279137-8] Webb, RL et al. (2009) A novel role for an APC2-Diaphanous complex in regulating actin organization in Drosophila. Development 136 1283-93 PubMed GONUTS page

[PMID:18045836-9] Liu, R et al. (2008) Sisyphus, the Drosophila myosin XV homolog, traffics within filopodia transporting key sensory and adhesion cargos. Development 135 53-63 PubMed GONUTS page

[PMID:16303556-10] Goshima, G et al. (2005) Length control of the metaphase spindle. Curr. Biol. 15 1979-88 PubMed GONUTS page

[PMID:16105886-11] Dzhindzhev, NS et al. (2005) Distinct mechanisms govern the localisation of Drosophila CLIP-190 to unattached kinetochores and microtubule plus-ends. J. Cell. Sci. 118 3781-90 PubMed GONUTS page

[PMID:15699215-12] Slep, KC et al. (2005) Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end. J. Cell Biol. 168 587-98 PubMed GONUTS page

[PMID:15591130-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Elliott, SL et al. (2005) EB1 is essential during Drosophila development and plays a crucial role in the integrity of chordotonal mechanosensory organs. Mol. Biol. Cell 16 891-901 PubMed GONUTS page

[PMID:12213835-14] 14.0 ^14.1 ^14.2 ^14.3 Rogers, SL et al. (2002) Drosophila EB1 is important for proper assembly, dynamics, and positioning of the mitotic spindle. J. Cell Biol. 158 873-84 PubMed GONUTS page

[PMID:12867052-15] 15.0 ^15.1 ^15.2 ^15.3 Grevengoed, EE & Peifer, M (2003) Cytoskeletal connections: building strong cells in new ways. Curr. Biol. 13 R568-70 PubMed GONUTS page

[PMID:11700298-16] Tepass, U et al. (2001) Epithelial cell polarity and cell junctions in Drosophila. Annu. Rev. Genet. 35 747-84 PubMed GONUTS page

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DROME:A1Z6P3

Contents

Annotations

Notes

References

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