DICDI:PAKD

Species (Taxon ID)	Dictyostelium discoideum (Slime mold). (44689)
Gene Name(s)	pakD (ECO:0000312 with EMBL:EAL72198.1)
Protein Name(s)	Serine/threonine-protein kinase pakD (ECO:0000250 with UniProtKB:Q869N2)
External Links
UniProt	Q55DD4
EMBL	AAFI02000005
RefSeq	XP_646197.1
ProteinModelPortal	Q55DD4
SMR	Q55DD4
STRING	44689.DDB0229968
PaxDb	Q55DD4
EnsemblProtists	EAL72198
GeneID	8617150
KEGG	ddi:DDB_G0269696
dictyBase	DDB_G0269696
eggNOG	KOG0578 ENOG410XP4K
InParanoid	Q55DD4
OMA	NENSFEV
Reactome	R-DDI-2029482 R-DDI-389359 R-DDI-3928662 R-DDI-445144 R-DDI-5621575 R-DDI-5627123 R-DDI-5687128
PRO	PR:Q55DD4
Proteomes	UP000002195 UP000002195
GO	GO:0031254 GO:0005737 GO:0031143 GO:0001931 GO:0005524 GO:0046872 GO:0004674 GO:0048365 GO:0030041 GO:0032147 GO:0031152 GO:0016477 GO:0043327 GO:1903665 GO:0051490 GO:0043408 GO:0007346 GO:0007266 GO:0023014 GO:0031098
CDD	cd00029
Gene3D	1.10.418.10 1.25.10.10 3.90.810.10
InterPro	IPR011989 IPR036872 IPR001715 IPR000095 IPR036936 IPR011009 IPR002219 IPR000719 IPR017441
Pfam	PF00130 PF00786 PF00069
SMART	SM00109 SM00220
SUPFAM	SSF47576 SSF56112
PROSITE	PS50021 PS50108 PS00107 PS50011 PS50081

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0034260	negative regulation of GTPase activity	PMID:30462573^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903669	positive regulation of chemorepellent activity	PMID:24797076^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0045499	chemorepellent activity	PMID:24797076^[2]	ECO:0000315			F		Fig (5b) shows that Dictyostelium discoideum cells lacking pakD showed significantly less AprA chemorepellent activity than wild type cells.	complete CACAO 13086
acts_upstream_of_or_within	GO:0110094	polyphosphate-mediated signaling	PMID:28584190^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051490	negative regulation of filopodium assembly	PMID:24797076^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043327	chemotaxis to cAMP	PMID:24243792^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031254	cell trailing edge	PMID:24797076^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031152	aggregation involved in sorocarp development	PMID:24243792^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031143	pseudopodium	PMID:24243792^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0042594)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030041	actin filament polymerization	PMID:24243792^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0071320)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903665	negative regulation of asexual reproduction	PMID:24797076^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0001931	uropod	PMID:24243792^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0042594)	Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919399 PANTHER:PTN000684825 RGD:727905 UniProtKB:Q7RTN6 UniProtKB:Q9C0K7	P		Seeded From UniProt	complete
involved_in	GO:0031098	stress-activated protein kinase signaling cascade	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 UniProtKB:A0A1D8PKE2 UniProtKB:A0A1D8PM87	P		Seeded From UniProt	complete
involved_in	GO:0023014	signal transduction by protein phosphorylation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 TAIR:locus:2205523 UniProtKB:Q9UEW8	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0267698 MGI:MGI:1339975 MGI:MGI:1344404 MGI:MGI:1346867 MGI:MGI:1346875 MGI:MGI:1891638 MGI:MGI:1928487 MGI:MGI:1929004 PANTHER:PTN000684825 PomBase:SPAC1F3.02c PomBase:SPBC17F3.02 PomBase:SPBC1D7.05 PomBase:SPBC409.07c PomBase:SPBC543.07 RGD:3780 RGD:620966 RGD:621643 SGD:S000000999 SGD:S000002318 SGD:S000002931 SGD:S000003664 SGD:S000004354 SGD:S000005757 SGD:S000006061 TAIR:locus:2017662 TAIR:locus:2074835 TAIR:locus:2087130 TAIR:locus:2170578 UniProtKB:A0A0B4KGS4 UniProtKB:O00506 UniProtKB:O95819 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q57Y61 UniProtKB:Q7RTN6 UniProtKB:Q8N4C8 UniProtKB:Q96PY6 UniProtKB:Q9C0K7 UniProtKB:Q9H2G2 UniProtKB:Q9P289 UniProtKB:Q9S7U9 UniProtKB:Q9UKE5 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 UniProtKB:Q9Y6R4 WB:WBGene00002177 WB:WBGene00002201 WB:WBGene00003368 WB:WBGene00013355 dictyBase:DDB_G0284181 dictyBase:DDB_G0286359	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0031030 FB:FBgn0035001 FB:FBgn0261456 FB:FBgn0267698 MGI:MGI:1344404 MGI:MGI:1346882 MGI:MGI:1349394 MGI:MGI:1355329 MGI:MGI:1858416 MGI:MGI:1917378 MGI:MGI:1920334 PANTHER:PTN000684825 PomBase:SPBC1604.14c PomBase:SPBC21.06c RGD:3250 RGD:3251 RGD:621643 RGD:708455 RGD:727905 SGD:S000005242 TAIR:locus:2035989 TAIR:locus:2045658 TAIR:locus:2080394 TAIR:locus:2116417 TAIR:locus:2133559 TAIR:locus:2174969 TAIR:locus:2205523 TAIR:locus:2206885 UniProtKB:A0A0B4KGS4 UniProtKB:C0H4N8 UniProtKB:O75914 UniProtKB:O94804 UniProtKB:O95747 UniProtKB:O95819 UniProtKB:O96013 UniProtKB:Q02750 UniProtKB:Q12851 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q13233 UniProtKB:Q8IVH8 UniProtKB:Q8N4C8 UniProtKB:Q92918 UniProtKB:Q99558 UniProtKB:Q9H2G2 UniProtKB:Q9H2K8 UniProtKB:Q9UEW8 UniProtKB:Q9UKE5 UniProtKB:Q9UL54 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 WB:WBGene00013355 WB:WBGene00017472 dictyBase:DDB_G0276459 dictyBase:DDB_G0286359	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002219	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Rijal, R et al. (2019) An endogenous chemorepellent directs cell movement by inhibiting pseudopods at one side of cells. Mol. Biol. Cell 30 242-255 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Phillips, JE & Gomer, RH (2014) The p21-activated kinase (PAK) family member PakD is required for chemorepulsion and proliferation inhibition by autocrine signals in Dictyostelium discoideum. PLoS ONE 9 e96633 PubMed GONUTS page
↑ Suess, PM et al. (2017) Extracellular polyphosphate signals through Ras and Akt to prime cells for development. J. Cell. Sci. 130 2394-2404 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Garcia, M et al. (2014) PakD, a putative p21-activated protein kinase in Dictyostelium discoideum, regulates actin. Eukaryotic Cell 13 119-26 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:30462573-1] Rijal, R et al. (2019) An endogenous chemorepellent directs cell movement by inhibiting pseudopods at one side of cells. Mol. Biol. Cell 30 242-255 PubMed GONUTS page

[PMID:24797076-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Phillips, JE & Gomer, RH (2014) The p21-activated kinase (PAK) family member PakD is required for chemorepulsion and proliferation inhibition by autocrine signals in Dictyostelium discoideum. PLoS ONE 9 e96633 PubMed GONUTS page

[PMID:28584190-3] Suess, PM et al. (2017) Extracellular polyphosphate signals through Ras and Akt to prime cells for development. J. Cell. Sci. 130 2394-2404 PubMed GONUTS page

[PMID:24243792-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Garcia, M et al. (2014) PakD, a putative p21-activated protein kinase in Dictyostelium discoideum, regulates actin. Eukaryotic Cell 13 119-26 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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DICDI:PAKD

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