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DICDI:NDKC

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Species (Taxon ID) Dictyostelium discoideum (Slime mold). (44689)
Gene Name(s) ndkC-2 (synonyms: gip17, ndkB)
Protein Name(s) Nucleoside diphosphate kinase, cytosolic

NDK NDP kinase

External Links
UniProt P22887
EMBL J05457
L23067
AAFI02000011
AAFI02000009
PIR A49547
RefSeq XP_644519.1
XP_644731.1
PDB 1B4S
1B99
1BUX
1F3F
1F6T
1HHQ
1HIY
1HLW
1KDN
1LEO
1LWX
1MN7
1MN9
1NCL
1NDC
1NDK
1NDP
1NPK
1NSP
1PAE
1S5Z
2BEF
3FKB
4C6A
PDBsum 1B4S
1B99
1BUX
1F3F
1F6T
1HHQ
1HIY
1HLW
1KDN
1LEO
1LWX
1MN7
1MN9
1NCL
1NDC
1NDK
1NDP
1NPK
1NSP
1PAE
1S5Z
2BEF
3FKB
4C6A
ProteinModelPortal P22887
SMR P22887
STRING 44689.DDB_0185051
SWISS-2DPAGE P22887
PRIDE P22887
EnsemblProtists DDB0185051
DDB0238334
GeneID 8618831
8619145
KEGG ddi:DDB_G0273069
ddi:DDB_G0273805
dictyBase DDB_G0273069
DDB_G0273805
eggNOG COG0105
InParanoid P22887
KO K00940
OMA ASKRIHM
PhylomeDB P22887
EvolutionaryTrace P22887
Proteomes UP000002195
UP000002195
GO GO:0005737
GO:0005856
GO:0045335
GO:0005886
GO:0005840
GO:0030141
GO:0005524
GO:0046872
GO:0004550
GO:0030036
GO:0016049
GO:0006241
GO:0006186
GO:0006187
GO:0007186
GO:0006183
GO:0045920
GO:0050765
GO:0048550
GO:0009142
GO:0009617
GO:0006414
GO:0006228
Gene3D 3.30.70.141
HAMAP MF_00451
InterPro IPR001564
IPR023005
Pfam PF00334
PRINTS PR01243
SMART SM00562
SUPFAM SSF54919
PROSITE PS00469

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016301

kinase activity

PMID:2161830[1]

ECO:0000314

F

Fig.5B shows the presence of NDP kinase activity as followed by the formation of ADP resulting from phosphate transfer from ATP to dTDP. Also, in order to confirm that the enhanced NDP kinase activity measured in the extracts of bacteria transformed with pNDK was actually due to the protein encoded by the Gipl7 cDNA, Fig. 6A shows the enzime was partially purified and compared to its elution profile with that of the control extracts in Fig. 6B.

complete
CACAO 12004

acts_upstream_of_or_within

GO:0050765

negative regulation of phagocytosis

PMID:21991393[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048550

negative regulation of pinocytosis

PMID:21991393[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045920

negative regulation of exocytosis

PMID:21991393[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0045335

phagocytic vesicle

PMID:19482547[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0045335

phagocytic vesicle

PMID:16926386[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030141

secretory granule

PMID:11990506[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030036

actin cytoskeleton organization

PMID:8816286[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019954

asexual reproduction

PMID:21991393[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0015629

actin cytoskeleton

PMID:21991393[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0009617

response to bacterium

PMID:19482547[3]

ECO:0007007

high throughput expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009142

nucleoside triphosphate biosynthetic process

PMID:2161830[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007186

G protein-coupled receptor signaling pathway

PMID:8389692[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006414

translational elongation

PMID:7733916[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006187

dGTP biosynthetic process from dGDP

PMID:2161830[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006186

dGDP phosphorylation

PMID:2161830[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:8389692[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

PMID:8816286[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005840

ribosome

PMID:7733916[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21991393[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:8244981[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:2161830[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004550

nucleoside diphosphate kinase activity

PMID:2161830[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004550

nucleoside diphosphate kinase activity

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10650
FB:FBgn0000150
PANTHER:PTN000887110
PomBase:SPAC806.07
RGD:619877
RGD:70497
SGD:S000001550
TAIR:locus:2137936
TAIR:locus:2161922
UniProtKB:O00746
UniProtKB:P15531
UniProtKB:P22392
UniProtKB:Q59636
UniProtKB:Q8ID43
ZFIN:ZDB-GENE-000210-33
dictyBase:DDB_G0273069

F

Seeded From UniProt

complete

enables

GO:0004550

nucleoside diphosphate kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001564

F

Seeded From UniProt

complete

involved_in

GO:0006165

nucleoside diphosphate phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001564

P

Seeded From UniProt

complete

involved_in

GO:0006183

GTP biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001564

P

Seeded From UniProt

complete

involved_in

GO:0006228

UTP biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001564

P

Seeded From UniProt

complete

involved_in

GO:0006241

CTP biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001564

P

Seeded From UniProt

complete

enables

GO:0004550

nucleoside diphosphate kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.4.6

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

involved_in

GO:0009117

nucleotide metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0546

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Lacombe, ML et al. (1990) Functional cloning of a nucleoside diphosphate kinase from Dictyostelium discoideum. J. Biol. Chem. 265 10012-8 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Annesley, SJ et al. (2011) Dictyostelium discoideum nucleoside diphosphate kinase C plays a negative regulatory role in phagocytosis, macropinocytosis and exocytosis. PLoS ONE 6 e26024 PubMed GONUTS page
  3. ↑ 3.0 3.1 Shevchuk, O et al. (2009) Proteomic analysis of Legionella-containing phagosomes isolated from Dictyostelium. Int. J. Med. Microbiol. 299 489-508 PubMed GONUTS page
  4. ↑ Gotthardt, D et al. (2006) Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake. Mol. Cell Proteomics 5 2228-43 PubMed GONUTS page
  5. ↑ Srinivasan, S et al. (2001) Proteomic analysis of a developmentally regulated secretory vesicle. Proteomics 1 1119-27 PubMed GONUTS page
  6. ↑ 6.0 6.1 Aguado-Velasco, C et al. (1996) NDP kinase can modulate contraction of Dictyostelium cytoskeletons. Cell Motil. Cytoskeleton 34 194-205 PubMed GONUTS page
  7. ↑ 7.0 7.1 Bominaar, AA et al. (1993) Activation of G-proteins by receptor-stimulated nucleoside diphosphate kinase in Dictyostelium. EMBO J. 12 2275-9 PubMed GONUTS page
  8. ↑ 8.0 8.1 Sonnemann, J & Mutzel, R (1995) Cytosolic nucleoside diphosphate kinase associated with the translation apparatus may provide GTP for protein synthesis. Biochem. Biophys. Res. Commun. 209 490-6 PubMed GONUTS page
  9. ↑ Troll, H et al. (1993) Separate nuclear genes encode cytosolic and mitochondrial nucleoside diphosphate kinase in Dictyostelium discoideum. J. Biol. Chem. 268 25469-75 PubMed GONUTS page
  10. ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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