DAPPU:E9HT81

Species (Taxon ID)	Daphnia pulex (Water flea). (6669)
Gene Name(s)	CCS1 (ECO:0000313 with EMBL:EFX65045.1)
Protein Name(s)	Copper chaperone for super oxide dismutase, CCS1 (ECO:0000313 with EMBL:EFX65045.1)
External Links
UniProt	E9HT81
EMBL	GL732766
ProteinModelPortal	E9HT81
EnsemblMetazoa	EFX65045
InParanoid	E9HT81
OMA	WEERDRP
PhylomeDB	E9HT81
Proteomes	UP000000305
GO	GO:0046872 GO:0030001 GO:0055114 GO:0006801
Gene3D	2.60.40.200
InterPro	IPR006121 IPR001424
Pfam	PF00403 PF00080
PRINTS	PR00068
SUPFAM	SSF49329 SSF55008
PROSITE	PS50846

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0015677	copper ion import	PMID:21865594	ECO:0000315			P		fig. 1: copper chaperone for Sod1 (Ccs1) We identified two cysteines (Cys-27 and Cys-64) in domain I that are required for mitochondrial import of Ccs1—but not for its role in Sod1 maturation—by the use of cysteine mutants.	complete
	GO:0018316	peptide cross-linking via L-cystine	PMID:21865594	ECO:0000315			P		fig 2C: we found that the C27–C64 disulfide was formed in the presence of Mia40-WT. Of importance, in the absence of functional Mia40 no oxidation of the two cysteines occurred	complete
involved_in	GO:0019430	removal of superoxide radicals		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0033631 MGI:MGI:98351 PANTHER:PTN000000113 PomBase:SPAC22E12.04 RGD:3731 UniProtKB:P00442 WB:WBGene00004930	P		Seeded From UniProt	complete
enables	GO:0016532	superoxide dismutase copper chaperone activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002224268 SGD:S000004641 UniProtKB:E1JH26 UniProtKB:Q59WC0	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002224268 SGD:S000004641 UniProtKB:E1JH26 UniProtKB:O14618	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002224268 SGD:S000004641 UniProtKB:O14618	C		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13419 PANTHER:PTN000000113 RGD:3731 UniProtKB:O14618 UniProtKB:P00441 UniProtKB:P00442 WB:WBGene00004930	F		Seeded From UniProt	complete
NOT|enables	GO:0004784	superoxide dismutase activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000000113 PANTHER:PTN002224268	F		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016532	P		Seeded From UniProt	complete
involved_in	GO:0006801	superoxide metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001424 InterPro:IPR036423	P		Seeded From UniProt	complete
involved_in	GO:0030001	metal ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006121 InterPro:IPR036163	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001424 InterPro:IPR006121 InterPro:IPR036163 InterPro:IPR036423	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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References

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