It is now the 5th OPEN Period for CACAO Fall 2017! It will end on Sunday November 19, 2017 at 11:59 pm CST
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

DANRE:RX2

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) rx2
Protein Name(s) Retinal homeobox protein Rx2
External Links
UniProt O42357
EMBL AF001908
RefSeq NP_571301.1
UniGene Dr.75762
ProteinModelPortal O42357
SMR O42357
STRING 7955.ENSDARP00000059002
GeneID 30473
KEGG dre:30473
CTD 30473
ZFIN ZDB-GENE-990415-237
eggNOG NOG261733
HOGENOM HOG000231518
HOVERGEN HBG021349
InParanoid O42357
KO K09332
PhylomeDB O42357
NextBio 20806866
Proteomes UP000000437
GO GO:0005634
GO:0043565
GO:0060219
GO:0006355
GO:0006351
Gene3D 1.10.10.60
InterPro IPR017970
IPR001356
IPR009057
IPR003654
Pfam PF00046
PF03826
SMART SM00389
SUPFAM SSF46689
PROSITE PS00027
PS50071
PS50803

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005634

nucleus

IEA: Inferred from Electronic Annotation

C

Source: UniProtKB-SubCell

Missing: with/from, reference

GO:0043565

sequence-specific DNA binding

IEA: Inferred from Electronic Annotation

F

Source: InterPro

Missing: with/from, reference

GO:0003700

transcription factor activity

IEA: Inferred from Electronic Annotation

F

Source: InterPro

Missing: with/from, reference

GO:0007275

multicellular organismal development

IEA: Inferred from Electronic Annotation

P

Source: UniProtKB-KW

Missing: with/from, reference

GO:0006355

regulation of transcription, DNA-dependent

IEA: Inferred from Electronic Annotation

P

Source: InterPro

Missing: with/from, reference

GO:0006350

transcription

IEA: Inferred from Electronic Annotation

P

Source: UniProtKB-KW

Missing: with/from, reference

GO:0010628

positive regulation of gene expression

PMID:19210961[1]

IMP: Inferred from Mutant Phenotype

P

Fig 3C,D,E Morpholino mediated rx2 depletion leads to reduced pax6 expression in optic primordia

complete

GO:0046671

negative regulation of retinal cell programmed cell death

PMID:19210961[1]

IMP: Inferred from Mutant Phenotype

P

Fig 6E Morpholino mediated rx2 depletion leads to increased retinal cell death as shown by acridine orange assays

complete

GO:0046549

retinal cone cell development

PMID:19210961[1]

IMP: Inferred from Mutant Phenotype

P

Fig 9B,L Morpholino mediated rx2 depletion leads to reduced expression of cone opsins and transducins as shown by northern blots

complete

GO:0046548

retinal rod cell development

PMID:19210961[1]

IMP: Inferred from Mutant Phenotype

P

Fig 9C, H Morpholino mediated rx2 depletion leads to reduced expression of rod opsins and transducins as shown by northern blots

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003654

F

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012287

F

complete

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

complete

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0371

F

complete

GO:0003700

sequence-specific DNA binding transcription factor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356

F

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003654

C

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

C

complete

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

complete

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

complete

GO:0006351

transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012287

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0805

P

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356
InterPro:IPR009057

F

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003654

P

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0217

P

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0371

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356

F

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

F

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

F

Seeded From UniProt

complete

GO:0060219

camera-type eye photoreceptor cell differentiation

PMID:19210961[1]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-060109-2
ZFIN:ZDB-MRPHLNO-060109-4
ZFIN:ZDB-MRPHLNO-100423-2
ZFIN:ZDB-MRPHLNO-100423-3

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Nelson, SM et al. (2009) Retinal homeobox 1 is required for retinal neurogenesis and photoreceptor differentiation in embryonic zebrafish. Dev. Biol. 328 24-39 PubMed GONUTS page