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The 3rd ANNOTATION Period for CACAO Fall 2018 has BEGUN! It will end on Sunday October 21, 2018 at 11:59 pm CDT
REMEMBER, any annotations to "____ BINDING" or "RESPONSE TO _____" will be marked as unacceptable for CACAO students according to the CACAO rules.

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DANRE:RX2

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) rx2
Protein Name(s) Retinal homeobox protein Rx2
External Links
UniProt O42357
EMBL AF001908
RefSeq NP_571301.1
UniGene Dr.75762
ProteinModelPortal O42357
SMR O42357
STRING 7955.ENSDARP00000059002
GeneID 30473
KEGG dre:30473
CTD 30473
ZFIN ZDB-GENE-990415-237
eggNOG NOG261733
HOGENOM HOG000231518
HOVERGEN HBG021349
InParanoid O42357
KO K09332
PhylomeDB O42357
NextBio 20806866
Proteomes UP000000437
GO GO:0005634
GO:0043565
GO:0060219
GO:0006355
GO:0006351
Gene3D 1.10.10.60
InterPro IPR017970
IPR001356
IPR009057
IPR003654
Pfam PF00046
PF03826
SMART SM00389
SUPFAM SSF46689
PROSITE PS00027
PS50071
PS50803

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005634

nucleus

IEA: Inferred from Electronic Annotation

C

Source: UniProtKB-SubCell

Missing: with/from, reference

GO:0043565

sequence-specific DNA binding

IEA: Inferred from Electronic Annotation

F

Source: InterPro

Missing: with/from, reference

GO:0003700

transcription factor activity

IEA: Inferred from Electronic Annotation

F

Source: InterPro

Missing: with/from, reference

GO:0007275

multicellular organismal development

IEA: Inferred from Electronic Annotation

P

Source: UniProtKB-KW

Missing: with/from, reference

GO:0006355

regulation of transcription, DNA-dependent

IEA: Inferred from Electronic Annotation

P

Source: InterPro

Missing: with/from, reference

GO:0006350

transcription

IEA: Inferred from Electronic Annotation

P

Source: UniProtKB-KW

Missing: with/from, reference

GO:0010628

positive regulation of gene expression

PMID:19210961[1]

IMP: Inferred from Mutant Phenotype

P

Fig 3C,D,E Morpholino mediated rx2 depletion leads to reduced pax6 expression in optic primordia

complete

GO:0046671

negative regulation of retinal cell programmed cell death

PMID:19210961[1]

IMP: Inferred from Mutant Phenotype

P

Fig 6E Morpholino mediated rx2 depletion leads to increased retinal cell death as shown by acridine orange assays

complete

GO:0046549

retinal cone cell development

PMID:19210961[1]

IMP: Inferred from Mutant Phenotype

P

Fig 9B,L Morpholino mediated rx2 depletion leads to reduced expression of cone opsins and transducins as shown by northern blots

complete

GO:0046548

retinal rod cell development

PMID:19210961[1]

IMP: Inferred from Mutant Phenotype

P

Fig 9C, H Morpholino mediated rx2 depletion leads to reduced expression of rod opsins and transducins as shown by northern blots

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003654

F

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012287

F

complete

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

complete

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0371

F

complete

GO:0003700

sequence-specific DNA binding transcription factor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356

F

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003654

C

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

C

complete

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

complete

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

complete

GO:0006351

transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012287

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0805

P

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356
InterPro:IPR009057

F

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003654

P

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0217

P

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0371

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356

F

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

F

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

F

Seeded From UniProt

complete

GO:0060219

camera-type eye photoreceptor cell differentiation

PMID:19210961[1]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-060109-2
ZFIN:ZDB-MRPHLNO-060109-4
ZFIN:ZDB-MRPHLNO-100423-2
ZFIN:ZDB-MRPHLNO-100423-3

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Nelson, SM et al. (2009) Retinal homeobox 1 is required for retinal neurogenesis and photoreceptor differentiation in embryonic zebrafish. Dev. Biol. 328 24-39 PubMed GONUTS page