DANRE:RX2

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	rx2
Protein Name(s)	Retinal homeobox protein Rx2
External Links
UniProt	O42357
EMBL	AF001908
RefSeq	NP_571301.1
UniGene	Dr.75762
ProteinModelPortal	O42357
SMR	O42357
STRING	7955.ENSDARP00000059002
GeneID	30473
KEGG	dre:30473
CTD	30473
ZFIN	ZDB-GENE-990415-237
eggNOG	NOG261733
HOGENOM	HOG000231518
HOVERGEN	HBG021349
InParanoid	O42357
KO	K09332
PhylomeDB	O42357
NextBio	20806866
Proteomes	UP000000437
GO	GO:0005634 GO:0043565 GO:0060219 GO:0006355 GO:0006351
Gene3D	1.10.10.60
InterPro	IPR017970 IPR001356 IPR009057 IPR003654
Pfam	PF00046 PF03826
SMART	SM00389
SUPFAM	SSF46689
PROSITE	PS00027 PS50071 PS50803

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010628	positive regulation of gene expression	PMID:19210961	ECO:0000315			P		Fig 3C,D,E Morpholino mediated rx2 depletion leads to reduced pax6 expression in optic primordia	complete
	GO:0046671	negative regulation of retinal cell programmed cell death	PMID:19210961	ECO:0000315			P		Fig 6E Morpholino mediated rx2 depletion leads to increased retinal cell death as shown by acridine orange assays	complete
	GO:0046549	retinal cone cell development	PMID:19210961	ECO:0000315			P		Fig 9B,L Morpholino mediated rx2 depletion leads to reduced expression of cone opsins and transducins as shown by northern blots	complete
	GO:0046548	retinal rod cell development	PMID:19210961	ECO:0000315			P		Fig 9C, H Morpholino mediated rx2 depletion leads to reduced expression of rod opsins and transducins as shown by northern blots	complete
involved_in	GO:0060219	camera-type eye photoreceptor cell differentiation	PMID:19210961	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060109-2 ZFIN:ZDB-MRPHLNO-060109-4 ZFIN:ZDB-MRPHLNO-100423-2 ZFIN:ZDB-MRPHLNO-100423-3	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032967	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032967	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0371 UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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References

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