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DANRE:RX1
Contents
| Species (Taxon ID) | Danio rerio (Zebrafish) (Brachydanio rerio). (7955) | |
| Gene Name(s) | rx1 | |
| Protein Name(s) | Retinal homeobox protein Rx1 | |
| External Links | ||
| UniProt | O42356 | |
| EMBL | AF001907 | |
| UniGene | Dr.75761 | |
| ProteinModelPortal | O42356 | |
| SMR | O42356 | |
| STRING | 7955.ENSDARP00000096944 | |
| ZFIN | ZDB-GENE-990415-236 | |
| eggNOG | NOG261733 | |
| HOGENOM | HOG000231518 | |
| HOVERGEN | HBG021349 | |
| InParanoid | O42356 | |
| PRO | PR:O42356 | |
| Proteomes | UP000000437 | |
| GO | GO:0005634 GO:0043565 GO:0007275 GO:0006355 GO:0006351 | |
| Gene3D | 1.10.10.60 | |
| InterPro | IPR017970 IPR001356 IPR009057 IPR003654 | |
| Pfam | PF00046 PF03826 | |
| SMART | SM00389 | |
| SUPFAM | SSF46689 | |
| PROSITE | PS00027 PS50071 PS50803 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0046549 |
retinal cone cell development |
ECO:0000315 |
P |
Fig 1N+P Fig 8 B,F,J,L Morpholino mediated rx1 depletion in zebra fish retinas leads to reduced cone cells as shown by immunocytochemistry. Morpholino mediated rx1 depletion leads to reduced expression of cone opsins and transducins as shown by northern blots |
complete | |||||
| GO:0046548 |
retinal rod cell development |
ECO:0000315 |
P |
Morpholino mediated rx1 depletion in zebra fish retinas leads to reduced rod cells as shown by immunocytochemistry. Morpholino mediated rx1 depletion leads to reduced expression of rod opsins and transducins as shown by northern blots. |
complete | |||||
| GO:0008285 |
negative regulation of cell proliferation |
ECO:0000315 |
P |
Fig 5F, H ,I Morpholino mediated rx1 depletion during late neurogenesis leads to increased mitotic cells in the retina as shown by immunocytochemistry |
complete | |||||
| GO:0008284 |
positive regulation of cell proliferation |
ECO:0000315 |
P |
Fig 5B, D,I Morpholino mediated rx1 depletion during early neurogenesis leads to reduced mitotic cells in the retina as shown by immunocytochemistry |
complete | |||||
| GO:0046671 |
negative regulation of retinal cell programmed cell death |
ECO:0000315 |
P |
Fig 6D,E,G,I,J Morpholino mediated rx1 depletion leads to increased retinal cell death as shown by acridine orange and TUNEL assays |
complete | |||||
| GO:0050767 |
regulation of neurogenesis |
ECO:0000315 |
P |
Fig 1F,H,J,L Morpholino mediated rx1 depletion leads to reduced staining for retinal ganglion cells |
complete | |||||
| GO:0010842 |
retina layer formation |
ECO:0000315 |
P |
Fig 1B Morpholino mediated rx1 depletion in zebra fish retinas impairs retinal lamination |
complete | |||||
|
involved_in |
GO:0060219 |
camera-type eye photoreceptor cell differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-060109-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060219 |
camera-type eye photoreceptor cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-060109-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010842 |
retina layer formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-060109-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0003407 |
neural retina development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-060109-2 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006366 |
transcription by RNA polymerase II |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
incorrect (CACAO) |
GO:0016015 |
morphogen activity |
ECO:0000315 |
F |
Fig 1B Morpholino mediated rx1 depletion in zebra fish retinas impairs retinal lamination and results in abnormal retinal morphology |
complete | ||||
Notes
References
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