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DANRE:RX1

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) rx1
Protein Name(s) Retinal homeobox protein Rx1
External Links
UniProt O42356
EMBL AF001907
UniGene Dr.75761
ProteinModelPortal O42356
SMR O42356
STRING 7955.ENSDARP00000096944
ZFIN ZDB-GENE-990415-236
eggNOG NOG261733
HOGENOM HOG000231518
HOVERGEN HBG021349
InParanoid O42356
PRO PR:O42356
Proteomes UP000000437
GO GO:0005634
GO:0043565
GO:0007275
GO:0006355
GO:0006351
Gene3D 1.10.10.60
InterPro IPR017970
IPR001356
IPR009057
IPR003654
Pfam PF00046
PF03826
SMART SM00389
SUPFAM SSF46689
PROSITE PS00027
PS50071
PS50803

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005634

nucleus

IEA: Inferred from Electronic Annotation

C

Source: UniProtKB-SubCell

Missing: with/from, reference

GO:0043565

sequence-specific DNA binding

IEA: Inferred from Electronic Annotation

F

Source: InterPro

Missing: with/from, reference

GO:0003700

transcription factor activity

IEA: Inferred from Electronic Annotation

F

Source: InterPro

Missing: with/from, reference

GO:0006355

regulation of transcription, DNA-dependent

IEA: Inferred from Electronic Annotation

P

Source: InterPro

Missing: with/from, reference

GO:0046549

retinal cone cell development

PMID:19210961[1]

IMP: Inferred from Mutant Phenotype

P

Fig 1N+P Fig 8 B,F,J,L Morpholino mediated rx1 depletion in zebra fish retinas leads to reduced cone cells as shown by immunocytochemistry. Morpholino mediated rx1 depletion leads to reduced expression of cone opsins and transducins as shown by northern blots

complete

GO:0006350

transcription

IEA: Inferred from Electronic Annotation

P

Source: UniProtKB-KW

Missing: with/from, reference

GO:0046548

retinal rod cell development

PMID:19210961[1]

IMP: Inferred from Mutant Phenotype

P

Morpholino mediated rx1 depletion in zebra fish retinas leads to reduced rod cells as shown by immunocytochemistry. Morpholino mediated rx1 depletion leads to reduced expression of rod opsins and transducins as shown by northern blots.

complete

GO:0008285

negative regulation of cell proliferation

PMID:19210961[1]

IMP: Inferred from Mutant Phenotype

P

Fig 5F, H ,I Morpholino mediated rx1 depletion during late neurogenesis leads to increased mitotic cells in the retina as shown by immunocytochemistry

complete

GO:0008284

positive regulation of cell proliferation

PMID:19210961[1]

IMP: Inferred from Mutant Phenotype

P

Fig 5B, D,I Morpholino mediated rx1 depletion during early neurogenesis leads to reduced mitotic cells in the retina as shown by immunocytochemistry

complete

GO:0046671

negative regulation of retinal cell programmed cell death

PMID:19210961[1]

IMP: Inferred from Mutant Phenotype

P

Fig 6D,E,G,I,J Morpholino mediated rx1 depletion leads to increased retinal cell death as shown by acridine orange and TUNEL assays

complete

GO:0050767

regulation of neurogenesis

PMID:19210961[1]

IMP: Inferred from Mutant Phenotype

P

Fig 1F,H,J,L Morpholino mediated rx1 depletion leads to reduced staining for retinal ganglion cells

complete

GO:0010842

retina layer formation

PMID:19210961[1]

IMP: Inferred from Mutant Phenotype

P

Fig 1B Morpholino mediated rx1 depletion in zebra fish retinas impairs retinal lamination

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003654

F

complete

incorrect (CACAO)

GO:0016015

morphogen activity

PMID:19210961[1]

IMP: Inferred from Mutant Phenotype

F

Fig 1B Morpholino mediated rx1 depletion in zebra fish retinas impairs retinal lamination and results in abnormal retinal morphology

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012287

F

complete

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

complete

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0371

F

complete

GO:0003700

sequence-specific DNA binding transcription factor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356

F

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003654

C

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

C

complete

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

complete

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

complete

GO:0006351

transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012287

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

P

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356
InterPro:IPR009057

F

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0805

P

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003654

P

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0371

F

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0217

P

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356

F

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

F

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Nelson, SM et al. (2009) Retinal homeobox 1 is required for retinal neurogenesis and photoreceptor differentiation in embryonic zebrafish. Dev. Biol. 328 24-39 PubMed GONUTS page