DANRE:Q9DGI6

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	acvr1l (ECO:0000313 with ZFIN:ZDB-GENE-990415-9)
Protein Name(s)	Type I serine-threonine kinase receptor (ECO:0000313 with EMBL:AAG01346.1)
External Links
UniProt	Q9DGI6
EMBL	AF292028
UniGene	Dr.75831
ProteinModelPortal	Q9DGI6
SMR	Q9DGI6
ZFIN	ZDB-GENE-990415-9
HOVERGEN	HBG054502
PhylomeDB	Q9DGI6
GO	GO:0070724 GO:0005938 GO:0005737 GO:0005887 GO:0005524 GO:0004702 GO:0005024 GO:0009952 GO:0030509 GO:0007420 GO:0003230 GO:0051216 GO:0021556 GO:0061371 GO:0035462 GO:0003140 GO:0007368 GO:0048264 GO:0060030 GO:0009953 GO:0035124 GO:0035050 GO:0003143 GO:0035162 GO:0003146 GO:0001947 GO:0048368 GO:0001889 GO:0048332 GO:0046588 GO:0042476 GO:0042475 GO:0003342 GO:0051260 GO:0006468 GO:0030510 GO:0001944
InterPro	IPR000472 IPR011009 IPR000719 IPR017441 IPR008271 IPR003605 IPR000333
PANTHER	PTHR23255
Pfam	PF01064 PF00069 PF08515
SMART	SM00467
SUPFAM	SSF56112
PROSITE	PS51256 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0070724	BMP receptor complex	PMID:19377468^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0061371	determination of heart left/right asymmetry	PMID:21937597^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080731-4	P	Seeded From UniProt	complete
involved_in	GO:0060030	dorsal convergence	PMID:17331724^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060920-2	P	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:19377468^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	PMID:14648845^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048368	lateral mesoderm development	PMID:19232521^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048332	mesoderm morphogenesis	PMID:11165484^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:9007231^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:18194657^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-110804-6	P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:16527746^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:12601179^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:11222141^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-960	P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:11222140^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:11222140^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060920-1 ZFIN:ZDB-MRPHLNO-060920-2	P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:11222140^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-960	P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:11165484^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048264	determination of ventral identity	PMID:11222140^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046588	negative regulation of calcium-dependent cell-cell adhesion	PMID:17331724^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060920-2	P	Seeded From UniProt	complete
involved_in	GO:0046588	negative regulation of calcium-dependent cell-cell adhesion	PMID:17331724^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042476	odontogenesis	PMID:11759004^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042476	odontogenesis	PMID:14745232^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035462	determination of left/right asymmetry in diencephalon	PMID:21937597^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080731-4	P	Seeded From UniProt	complete
involved_in	GO:0035162	embryonic hemopoiesis	PMID:16527746^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-060403-1	P	Seeded From UniProt	complete
involved_in	GO:0035124	embryonic caudal fin morphogenesis	PMID:11222141^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-960	P	Seeded From UniProt	complete
involved_in	GO:0035050	embryonic heart tube development	PMID:18267096^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080731-4	P	Seeded From UniProt	complete
involved_in	GO:0030510	regulation of BMP signaling pathway	PMID:12601179^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-980526-373	P	Seeded From UniProt	complete
involved_in	GO:0030510	regulation of BMP signaling pathway	PMID:14648845^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-960	P	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:22484487^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060920-2 ZFIN:ZDB-MRPHLNO-120614-7	P	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:11222141^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-980526-474	P	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:11222141^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-000208-25	P	Seeded From UniProt	complete
involved_in	GO:0021556	central nervous system formation	PMID:11165484^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:22484487^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060920-2 ZFIN:ZDB-MRPHLNO-120614-7	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:12601179^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-980526-373	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:11165484^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-980526-527	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:19855136^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080731-4	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:19377468^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060920-2 ZFIN:ZDB-MRPHLNO-090610-3	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:16775002^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:11969259^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-960	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:11222141^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-960	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:11165484^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	PMID:12482931^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-960	P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:14648845^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:9334285^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9566954^[22]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04771	P	Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:18248203^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:9566954^[22]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37172	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18248203^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:9566954^[22]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04771	F	Seeded From UniProt	complete
involved_in	GO:0003342	proepicardium development	PMID:20413782^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080731-4	P	Seeded From UniProt	complete
involved_in	GO:0003230	cardiac atrium development	PMID:19232521^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0003146	heart jogging	PMID:9334285^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0003143	embryonic heart tube morphogenesis	PMID:9334285^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0003140	determination of left/right asymmetry in lateral mesoderm	PMID:21937597^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080731-4	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:9334285^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:17395172^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-960	P	Seeded From UniProt	complete
involved_in	GO:0001944	vasculature development	PMID:11222141^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-960	P	Seeded From UniProt	complete
involved_in	GO:0001889	liver development	PMID:17507405^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-960	P	Seeded From UniProt	complete
involved_in	GO:0001503	ossification	PMID:28394244^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-190109-3	P	Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002356032 UniProtKB:P37023	F	Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN002356032 UniProtKB:P37023 UniProtKB:Q04771	F	Seeded From UniProt	complete
part_of	GO:0048179	activin receptor complex	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002356032 RGD:620200 UniProtKB:Q04771	C	Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:621789 UniProtKB:O00238 UniProtKB:P36894 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771	F	Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000583675 UniProtKB:P27037 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37173 UniProtKB:Q13705	C	Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102806 MGI:MGI:87911 MGI:MGI:87912 PANTHER:PTN000583675 RGD:71082 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:Q13705 UniProtKB:Q8NER5	F	Seeded From UniProt	complete
contributes_to	GO:0016361	activin receptor activity, type I	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN002356032 RGD:620200 UniProtKB:P37023 UniProtKB:Q04771	F	Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338938 MGI:MGI:87912 PANTHER:PTN000583675	P	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003716 MGI:MGI:1338946 MGI:MGI:87911 MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:3852 RGD:620200 RGD:69651 RGD:70964 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771 UniProtKB:Q06900 UniProtKB:Q90ZK6	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN000583675 RGD:69651 RGD:70964 UniProtKB:P36896 UniProtKB:P37023 UniProtKB:Q04771 UniProtKB:Q13873	C	Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN002356032 UniProtKB:A0A0B4K7J3 UniProtKB:P37023 UniProtKB:Q90ZK6	F	Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 ZFIN:ZDB-GENE-070618-1	F	Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016361	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR003605	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000719 InterPro:IPR003605 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR003605 InterPro:IPR008271	P	Seeded From UniProt	complete
involved_in	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR003605	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Little, SC & Mullins, MC (2009) Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nat. Cell Biol. 11 637-43 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Lenhart, KF et al. (2011) Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish. Development 138 4405-10 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 von der Hardt, S et al. (2007) The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion. Curr. Biol. 17 475-87 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Payne-Ferreira, TL & Yelick, PC (2003) Alk8 is required for neural crest cell formation and development of pharyngeal arch cartilages. Dev. Dyn. 228 683-96 PubMed GONUTS page
↑ ^5.0 ^5.1 Marques, SR & Yelon, D (2009) Differential requirement for BMP signaling in atrial and ventricular lineages establishes cardiac chamber proportionality. Dev. Biol. 328 472-82 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Payne, TL et al. (2001) Functional characterization and genetic mapping of alk8. Mech. Dev. 100 275-89 PubMed GONUTS page
↑ Mullins, MC et al. (1996) Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes. Development 123 81-93 PubMed GONUTS page
↑ Tucker, JA et al. (2008) The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axis. Dev. Cell 14 108-19 PubMed GONUTS page
↑ ^9.0 ^9.1 Hogan, BM et al. (2006) Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish. Curr. Biol. 16 506-11 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Sidi, S et al. (2003) Maternal induction of ventral fate by zebrafish radar. Proc. Natl. Acad. Sci. U.S.A. 100 3315-20 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Mintzer, KA et al. (2001) Lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation. Development 128 859-69 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Bauer, H et al. (2001) The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo. Development 128 849-58 PubMed GONUTS page
↑ Payne, TL et al. (2001) Regulation of tooth development by the novel type I TGFbeta family member receptor Alk8. J. Dent. Res. 80 1968-73 PubMed GONUTS page
↑ Perrino, MA & Yelick, PC (2004) Immunolocalization of Alk8 during replacement tooth development in zebrafish. Cells Tissues Organs (Print) 176 17-27 PubMed GONUTS page
↑ Smith, KA et al. (2008) Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. Dev. Cell 14 287-97 PubMed GONUTS page
↑ ^16.0 ^16.1 Umasankar, PK et al. (2012) Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. Nat. Cell Biol. 14 488-501 PubMed GONUTS page
↑ Shen, Q et al. (2009) The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization. J. Clin. Invest. 119 3462-72 PubMed GONUTS page
↑ Reim, G & Brand, M (2006) Maternal control of vertebrate dorsoventral axis formation and epiboly by the POU domain protein Spg/Pou2/Oct4. Development 133 2757-70 PubMed GONUTS page
↑ Wagner, DS & Mullins, MC (2002) Modulation of BMP activity in dorsal-ventral pattern formation by the chordin and ogon antagonists. Dev. Biol. 245 109-23 PubMed GONUTS page
↑ Locascio, A et al. (2002) Modularity and reshuffling of Snail and Slug expression during vertebrate evolution. Proc. Natl. Acad. Sci. U.S.A. 99 16841-6 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Chen, JN et al. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124 4373-82 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Yelick, PC et al. (1998) zALK-8, a novel type I serine/threonine kinase receptor, is expressed throughout early zebrafish development. Dev. Dyn. 211 352-61 PubMed GONUTS page
↑ ^23.0 ^23.1 Payne-Ferreira, TL et al. (2004) Maternal alk8 promoter fragment directs expression in early oocytes. Zebrafish 1 27-39 PubMed GONUTS page
↑ Liu, J & Stainier, DY (2010) Tbx5 and Bmp signaling are essential for proepicardium specification in zebrafish. Circ. Res. 106 1818-28 PubMed GONUTS page
↑ Chocron, S et al. (2007) Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points. Dev. Biol. 305 577-88 PubMed GONUTS page
↑ Shin, D et al. (2007) Bmp and Fgf signaling are essential for liver specification in zebrafish. Development 134 2041-50 PubMed GONUTS page
↑ LaBonty, M et al. (2017) A Zebrafish Model of Human Fibrodysplasia Ossificans Progressiva. Zebrafish 14 293-304 PubMed GONUTS page
↑ ^28.00 ^28.01 ^28.02 ^28.03 ^28.04 ^28.05 ^28.06 ^28.07 ^28.08 ^28.09 ^28.10 ^28.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19377468-1] 1.0 ^1.1 ^1.2 Little, SC & Mullins, MC (2009) Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nat. Cell Biol. 11 637-43 PubMed GONUTS page

[PMID:21937597-2] 2.0 ^2.1 ^2.2 Lenhart, KF et al. (2011) Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish. Development 138 4405-10 PubMed GONUTS page

[PMID:17331724-3] 3.0 ^3.1 ^3.2 von der Hardt, S et al. (2007) The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion. Curr. Biol. 17 475-87 PubMed GONUTS page

[PMID:14648845-4] 4.0 ^4.1 ^4.2 Payne-Ferreira, TL & Yelick, PC (2003) Alk8 is required for neural crest cell formation and development of pharyngeal arch cartilages. Dev. Dyn. 228 683-96 PubMed GONUTS page

[PMID:19232521-5] 5.0 ^5.1 Marques, SR & Yelon, D (2009) Differential requirement for BMP signaling in atrial and ventricular lineages establishes cardiac chamber proportionality. Dev. Biol. 328 472-82 PubMed GONUTS page

[PMID:11165484-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Payne, TL et al. (2001) Functional characterization and genetic mapping of alk8. Mech. Dev. 100 275-89 PubMed GONUTS page

[PMID:9007231-7] Mullins, MC et al. (1996) Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes. Development 123 81-93 PubMed GONUTS page

[PMID:18194657-8] Tucker, JA et al. (2008) The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axis. Dev. Cell 14 108-19 PubMed GONUTS page

[PMID:16527746-9] 9.0 ^9.1 Hogan, BM et al. (2006) Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish. Curr. Biol. 16 506-11 PubMed GONUTS page

[PMID:12601179-10] 10.0 ^10.1 ^10.2 Sidi, S et al. (2003) Maternal induction of ventral fate by zebrafish radar. Proc. Natl. Acad. Sci. U.S.A. 100 3315-20 PubMed GONUTS page

[PMID:11222141-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Mintzer, KA et al. (2001) Lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation. Development 128 859-69 PubMed GONUTS page

[PMID:11222140-12] 12.0 ^12.1 ^12.2 ^12.3 Bauer, H et al. (2001) The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo. Development 128 849-58 PubMed GONUTS page

[PMID:11759004-13] Payne, TL et al. (2001) Regulation of tooth development by the novel type I TGFbeta family member receptor Alk8. J. Dent. Res. 80 1968-73 PubMed GONUTS page

[PMID:14745232-14] Perrino, MA & Yelick, PC (2004) Immunolocalization of Alk8 during replacement tooth development in zebrafish. Cells Tissues Organs (Print) 176 17-27 PubMed GONUTS page

[PMID:18267096-15] Smith, KA et al. (2008) Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. Dev. Cell 14 287-97 PubMed GONUTS page

[PMID:22484487-16] 16.0 ^16.1 Umasankar, PK et al. (2012) Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. Nat. Cell Biol. 14 488-501 PubMed GONUTS page

[PMID:19855136-17] Shen, Q et al. (2009) The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization. J. Clin. Invest. 119 3462-72 PubMed GONUTS page

[PMID:16775002-18] Reim, G & Brand, M (2006) Maternal control of vertebrate dorsoventral axis formation and epiboly by the POU domain protein Spg/Pou2/Oct4. Development 133 2757-70 PubMed GONUTS page

[PMID:11969259-19] Wagner, DS & Mullins, MC (2002) Modulation of BMP activity in dorsal-ventral pattern formation by the chordin and ogon antagonists. Dev. Biol. 245 109-23 PubMed GONUTS page

[PMID:12482931-20] Locascio, A et al. (2002) Modularity and reshuffling of Snail and Slug expression during vertebrate evolution. Proc. Natl. Acad. Sci. U.S.A. 99 16841-6 PubMed GONUTS page

[PMID:9334285-21] 21.0 ^21.1 ^21.2 ^21.3 Chen, JN et al. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124 4373-82 PubMed GONUTS page

[PMID:9566954-22] 22.0 ^22.1 ^22.2 Yelick, PC et al. (1998) zALK-8, a novel type I serine/threonine kinase receptor, is expressed throughout early zebrafish development. Dev. Dyn. 211 352-61 PubMed GONUTS page

[PMID:18248203-23] 23.0 ^23.1 Payne-Ferreira, TL et al. (2004) Maternal alk8 promoter fragment directs expression in early oocytes. Zebrafish 1 27-39 PubMed GONUTS page

[PMID:20413782-24] Liu, J & Stainier, DY (2010) Tbx5 and Bmp signaling are essential for proepicardium specification in zebrafish. Circ. Res. 106 1818-28 PubMed GONUTS page

[PMID:17395172-25] Chocron, S et al. (2007) Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points. Dev. Biol. 305 577-88 PubMed GONUTS page

[PMID:17507405-26] Shin, D et al. (2007) Bmp and Fgf signaling are essential for liver specification in zebrafish. Development 134 2041-50 PubMed GONUTS page

[PMID:28394244-27] LaBonty, M et al. (2017) A Zebrafish Model of Human Fibrodysplasia Ossificans Progressiva. Zebrafish 14 293-304 PubMed GONUTS page

[PMID:21873635-28] 28.00 ^28.01 ^28.02 ^28.03 ^28.04 ^28.05 ^28.06 ^28.07 ^28.08 ^28.09 ^28.10 ^28.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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