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DANRE:Q9DGI6

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) acvr1l (ECO:0000313 with ZFIN:ZDB-GENE-990415-9)
Protein Name(s) Type I serine-threonine kinase receptor (ECO:0000313 with EMBL:AAG01346.1)
External Links
UniProt Q9DGI6
EMBL AF292028
UniGene Dr.75831
ProteinModelPortal Q9DGI6
SMR Q9DGI6
ZFIN ZDB-GENE-990415-9
HOVERGEN HBG054502
PhylomeDB Q9DGI6
GO GO:0070724
GO:0005938
GO:0005737
GO:0005887
GO:0005524
GO:0004702
GO:0005024
GO:0009952
GO:0030509
GO:0007420
GO:0003230
GO:0051216
GO:0021556
GO:0061371
GO:0035462
GO:0003140
GO:0007368
GO:0048264
GO:0060030
GO:0009953
GO:0035124
GO:0035050
GO:0003143
GO:0035162
GO:0003146
GO:0001947
GO:0048368
GO:0001889
GO:0048332
GO:0046588
GO:0042476
GO:0042475
GO:0003342
GO:0051260
GO:0006468
GO:0030510
GO:0001944
InterPro IPR000472
IPR011009
IPR000719
IPR017441
IPR008271
IPR003605
IPR000333
PANTHER PTHR23255
Pfam PF01064
PF00069
PF08515
SMART SM00467
SUPFAM SSF56112
PROSITE PS51256
PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0001889

liver development

PMID:17507405[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-960

P

Seeded From UniProt

complete

GO:0001944

vasculature development

PMID:11222141[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-960

P

Seeded From UniProt

complete

GO:0001947

heart looping

PMID:17395172[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-960

P

Seeded From UniProt

complete

GO:0001947

heart looping

PMID:9334285[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003140

determination of left/right asymmetry in lateral mesoderm

PMID:21937597[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-080731-4

P

Seeded From UniProt

complete

GO:0003143

embryonic heart tube morphogenesis

PMID:9334285[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003146

heart jogging

PMID:9334285[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003230

cardiac atrium development

PMID:19232521[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003342

proepicardium development

PMID:20413782[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-080731-4

P

Seeded From UniProt

complete

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008271

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

GO:0004675

transmembrane receptor protein serine/threonine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003605

F

Seeded From UniProt

complete

GO:0004702

receptor signaling protein serine/threonine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000333

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19377468[8]

IPI: Inferred from Physical Interaction

UniProtKB:O93243

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000333
InterPro:IPR000719
InterPro:IPR003605
InterPro:IPR017441

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005524

ATP binding

PMID:9566954[9]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q04771

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:18248203[10]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005887

integral component of plasma membrane

PMID:9566954[9]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P37172

C

Seeded From UniProt

complete

GO:0005938

cell cortex

PMID:18248203[10]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR003605
InterPro:IPR008271

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:9566954[9]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q04771

P

Seeded From UniProt

complete

GO:0007178

transmembrane receptor protein serine/threonine kinase signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000333

P

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:9334285[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007420

brain development

PMID:14648845[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009952

anterior/posterior pattern specification

PMID:12482931[12]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-960

P

Seeded From UniProt

complete

GO:0009953

dorsal/ventral pattern formation

PMID:11165484[13]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-980526-527

P

Seeded From UniProt

complete

GO:0009953

dorsal/ventral pattern formation

PMID:11165484[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009953

dorsal/ventral pattern formation

PMID:11222141[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-960

P

Seeded From UniProt

complete

GO:0009953

dorsal/ventral pattern formation

PMID:11969259[14]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-960

P

Seeded From UniProt

complete

GO:0009953

dorsal/ventral pattern formation

PMID:12601179[15]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-980526-373

P

Seeded From UniProt

complete

GO:0009953

dorsal/ventral pattern formation

PMID:16775002[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009953

dorsal/ventral pattern formation

PMID:19377468[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060920-2
ZFIN:ZDB-MRPHLNO-090610-3

P

Seeded From UniProt

complete

GO:0009953

dorsal/ventral pattern formation

PMID:19855136[17]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-080731-4

P

Seeded From UniProt

complete

GO:0009953

dorsal/ventral pattern formation

PMID:22484487[18]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-060920-2
ZFIN:ZDB-MRPHLNO-120614-7

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000333
InterPro:IPR003605

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016301

kinase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

GO:0016310

phosphorylation

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0021556

central nervous system formation

PMID:11165484[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0023014

signal transduction by protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000333

P

Seeded From UniProt

complete

GO:0030509

BMP signaling pathway

PMID:11222141[2]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-000208-25

P

Seeded From UniProt

complete

GO:0030509

BMP signaling pathway

PMID:11222141[2]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-980526-474

P

Seeded From UniProt

complete

GO:0030509

BMP signaling pathway

PMID:22484487[18]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-060920-2
ZFIN:ZDB-MRPHLNO-120614-7

P

Seeded From UniProt

complete

GO:0030510

regulation of BMP signaling pathway

PMID:12601179[15]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-980526-373

P

Seeded From UniProt

complete

GO:0030510

regulation of BMP signaling pathway

PMID:14648845[11]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-960

P

Seeded From UniProt

complete

GO:0035050

embryonic heart tube development

PMID:18267096[19]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-080731-4

P

Seeded From UniProt

complete

GO:0035124

embryonic caudal fin morphogenesis

PMID:11222141[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-960

P

Seeded From UniProt

complete

GO:0035162

embryonic hemopoiesis

PMID:16527746[20]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-060403-1

P

Seeded From UniProt

complete

GO:0035462

determination of left/right asymmetry in diencephalon

PMID:21937597[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-080731-4

P

Seeded From UniProt

complete

GO:0042476

odontogenesis

PMID:11759004[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042476

odontogenesis

PMID:14745232[22]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0046588

negative regulation of calcium-dependent cell-cell adhesion

PMID:17331724[23]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0046588

negative regulation of calcium-dependent cell-cell adhesion

PMID:17331724[23]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060920-2

P

Seeded From UniProt

complete

GO:0048264

determination of ventral identity

PMID:11165484[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048264

determination of ventral identity

PMID:11222140[24]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0048264

determination of ventral identity

PMID:11222140[24]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048264

determination of ventral identity

PMID:11222140[24]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-960

P

Seeded From UniProt

complete

GO:0048264

determination of ventral identity

PMID:11222140[24]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060920-1
ZFIN:ZDB-MRPHLNO-060920-2

P

Seeded From UniProt

complete

GO:0048264

determination of ventral identity

PMID:11222141[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-960

P

Seeded From UniProt

complete

GO:0048264

determination of ventral identity

PMID:12601179[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048264

determination of ventral identity

PMID:16527746[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048264

determination of ventral identity

PMID:18194657[25]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-110804-6

P

Seeded From UniProt

complete

GO:0048264

determination of ventral identity

PMID:9007231[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048332

mesoderm morphogenesis

PMID:11165484[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048368

lateral mesoderm development

PMID:19232521[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051216

cartilage development

PMID:14648845[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051260

protein homooligomerization

PMID:19377468[8]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0060030

dorsal convergence

PMID:17331724[23]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060920-2

P

Seeded From UniProt

complete

GO:0061371

determination of heart left/right asymmetry

PMID:21937597[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-080731-4

P

Seeded From UniProt

complete

GO:0070724

BMP receptor complex

PMID:19377468[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Shin, D et al. (2007) Bmp and Fgf signaling are essential for liver specification in zebrafish. Development 134 2041-50 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Mintzer, KA et al. (2001) Lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation. Development 128 859-69 PubMed GONUTS page
  3. Chocron, S et al. (2007) Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points. Dev. Biol. 305 577-88 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Chen, JN et al. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124 4373-82 PubMed GONUTS page
  5. 5.0 5.1 5.2 Lenhart, KF et al. (2011) Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish. Development 138 4405-10 PubMed GONUTS page
  6. 6.0 6.1 Marques, SR & Yelon, D (2009) Differential requirement for BMP signaling in atrial and ventricular lineages establishes cardiac chamber proportionality. Dev. Biol. 328 472-82 PubMed GONUTS page
  7. Liu, J & Stainier, DY (2010) Tbx5 and Bmp signaling are essential for proepicardium specification in zebrafish. Circ. Res. 106 1818-28 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Little, SC & Mullins, MC (2009) Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nat. Cell Biol. 11 637-43 PubMed GONUTS page
  9. 9.0 9.1 9.2 Yelick, PC et al. (1998) zALK-8, a novel type I serine/threonine kinase receptor, is expressed throughout early zebrafish development. Dev. Dyn. 211 352-61 PubMed GONUTS page
  10. 10.0 10.1 Payne-Ferreira, TL et al. (2004) Maternal alk8 promoter fragment directs expression in early oocytes. Zebrafish 1 27-39 PubMed GONUTS page
  11. 11.0 11.1 11.2 Payne-Ferreira, TL & Yelick, PC (2003) Alk8 is required for neural crest cell formation and development of pharyngeal arch cartilages. Dev. Dyn. 228 683-96 PubMed GONUTS page
  12. Locascio, A et al. (2002) Modularity and reshuffling of Snail and Slug expression during vertebrate evolution. Proc. Natl. Acad. Sci. U.S.A. 99 16841-6 PubMed GONUTS page
  13. 13.0 13.1 13.2 13.3 13.4 Payne, TL et al. (2001) Functional characterization and genetic mapping of alk8. Mech. Dev. 100 275-89 PubMed GONUTS page
  14. Wagner, DS & Mullins, MC (2002) Modulation of BMP activity in dorsal-ventral pattern formation by the chordin and ogon antagonists. Dev. Biol. 245 109-23 PubMed GONUTS page
  15. 15.0 15.1 15.2 Sidi, S et al. (2003) Maternal induction of ventral fate by zebrafish radar. Proc. Natl. Acad. Sci. U.S.A. 100 3315-20 PubMed GONUTS page
  16. Reim, G & Brand, M (2006) Maternal control of vertebrate dorsoventral axis formation and epiboly by the POU domain protein Spg/Pou2/Oct4. Development 133 2757-70 PubMed GONUTS page
  17. Shen, Q et al. (2009) The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization. J. Clin. Invest. 119 3462-72 PubMed GONUTS page
  18. 18.0 18.1 Umasankar, PK et al. (2012) Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. Nat. Cell Biol. 14 488-501 PubMed GONUTS page
  19. Smith, KA et al. (2008) Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. Dev. Cell 14 287-97 PubMed GONUTS page
  20. 20.0 20.1 Hogan, BM et al. (2006) Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish. Curr. Biol. 16 506-11 PubMed GONUTS page
  21. Payne, TL et al. (2001) Regulation of tooth development by the novel type I TGFbeta family member receptor Alk8. J. Dent. Res. 80 1968-73 PubMed GONUTS page
  22. Perrino, MA & Yelick, PC (2004) Immunolocalization of Alk8 during replacement tooth development in zebrafish. Cells Tissues Organs (Print) 176 17-27 PubMed GONUTS page
  23. 23.0 23.1 23.2 von der Hardt, S et al. (2007) The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion. Curr. Biol. 17 475-87 PubMed GONUTS page
  24. 24.0 24.1 24.2 24.3 Bauer, H et al. (2001) The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo. Development 128 849-58 PubMed GONUTS page
  25. Tucker, JA et al. (2008) The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axis. Dev. Cell 14 108-19 PubMed GONUTS page
  26. Mullins, MC et al. (1996) Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes. Development 123 81-93 PubMed GONUTS page