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DANRE:Q9DD89

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) ctsd (ECO:0000313 with ZFIN:ZDB-GENE-010131-8) (synonyms: cathepsin D (ECO:0000313 with EMBL:CAC20111.1))
Protein Name(s) Cathepsin D enzyme (ECO:0000313 with EMBL:CAC20111.1)
External Links
UniProt Q9DD89
EMBL AJ278268
RefSeq NP_571785.1
UniGene Dr.19238
ProteinModelPortal Q9DD89
SMR Q9DD89
MEROPS A01.010
PRIDE Q9DD89
GeneID 65225
KEGG dre:65225
CTD 1509
ZFIN ZDB-GENE-010131-8
HOGENOM HOG000197681
HOVERGEN HBG000482
KO K01379
PhylomeDB Q9DD89
NextBio 20902022
Bgee Q9DD89
GO GO:0004190
GO:0061061
GO:0009617
GO:0003406
Gene3D 2.40.70.10
InterPro IPR001461
IPR001969
IPR012848
IPR021109
PANTHER PTHR13683
Pfam PF07966
PF00026
PRINTS PR00792
SUPFAM SSF50630
PROSITE PS00141

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004190

aspartic-type endopeptidase activity

PMID:21747967[1]

IDA: Inferred from Direct Assay

F

Figure 3

complete
CACAO 7299

GO:0003406

retinal pigment epithelium development

PMID:21747967[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-110722-1

P

Seeded From UniProt

complete

GO:0004190

aspartic-type endopeptidase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001461
InterPro:IPR001969
InterPro:IPR012848

F

Seeded From UniProt

complete

GO:0004190

aspartic-type endopeptidase activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000342793

F

Seeded From UniProt

complete

GO:0004190

aspartic-type endopeptidase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0064

F

Seeded From UniProt

complete

GO:0004190

aspartic-type endopeptidase activity

PMID:21747967[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005615

extracellular space

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001007735

C

Seeded From UniProt

complete

GO:0005764

lysosome

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001007735

C

Seeded From UniProt

complete

GO:0006508

proteolysis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001461
InterPro:IPR001969
InterPro:IPR012848

P

Seeded From UniProt

complete

GO:0006508

proteolysis

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000342793

P

Seeded From UniProt

complete

GO:0006508

proteolysis

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

GO:0006914

autophagy

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001415123

P

Seeded From UniProt

complete

GO:0008233

peptidase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

GO:0009617

response to bacterium

PMID:15829308[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0030163

protein catabolic process

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000342793

P

Seeded From UniProt

complete

GO:0061061

muscle structure development

PMID:23464837[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-110722-1

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Follo, C et al. (2011) Knock-down of cathepsin D affects the retinal pigment epithelium, impairs swim-bladder ontogenesis and causes premature death in zebrafish. PLoS ONE 6 e21908 PubMed GONUTS page
  2. Meijer, AH et al. (2005) Transcriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to Mycobacterium marinum infection. Mol. Immunol. 42 1185-203 PubMed GONUTS page
  3. Follo, C et al. (2013) Knockdown of cathepsin D in zebrafish fertilized eggs determines congenital myopathy. Biosci. Rep. 33 e00034 PubMed GONUTS page