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This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.
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DANRE:Q7ZU02

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) No Information Provided.
Protein Name(s) Chemokine (C-X-C motif) receptor 4a (ECO:0000313 with EMBL:AAH50172.1)
External Links
UniProt Q7ZU02
EMBL BC050172
RefSeq NP_571957.2
UniGene Dr.84258
ProteinModelPortal Q7ZU02
STRING 7955.ENSDARP00000074800
GeneID 140747
KEGG dre:140747
CTD 140747
ZFIN ZDB-GENE-020102-1
eggNOG NOG328039
HOGENOM HOG000234122
HOVERGEN HBG106917
KO K04189
NextBio 20797039
GO GO:0016021
GO:0016494
GO:0006935
GO:0042119
InterPro IPR001277
IPR000355
IPR000276
IPR017452
PANTHER PTHR24227
PTHR24227:SF7
Pfam PF00001
PRINTS PR00657
PR00645
PR00237
PROSITE PS00237
PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0008283

cell population proliferation

PMID:22782722[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903045

neural crest cell migration involved in sympathetic nervous system development

PMID:25607881[2]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-031009-1

P

Seeded From UniProt

complete

involved_in

GO:0061053

somite development

PMID:28701377[3]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-030710-1

P

Seeded From UniProt

complete

involved_in

GO:0061053

somite development

PMID:28701377[3]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-020708-3

P

Seeded From UniProt

complete

involved_in

GO:0061053

somite development

PMID:28701377[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-071022-1

P

Seeded From UniProt

complete

involved_in

GO:0060231

mesenchymal to epithelial transition

PMID:28701377[3]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-030710-1

P

Seeded From UniProt

complete

GO:0008283

cell proliferation

PMID:22782722[1]

ECO:0000315

P

Figure 3: Results show that Cxcr4a is essential for endodermal cell proliferation

complete
CACAO 6486

involved_in

GO:0060231

mesenchymal to epithelial transition

PMID:28701377[3]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-020708-3

P

Seeded From UniProt

complete

involved_in

GO:0060231

mesenchymal to epithelial transition

PMID:28701377[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-071022-1

P

Seeded From UniProt

complete

involved_in

GO:0055002

striated muscle cell development

PMID:17517144[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-071022-1

P

Seeded From UniProt

complete

involved_in

GO:0048703

embryonic viscerocranium morphogenesis

PMID:25607881[2]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-031009-1

P

Seeded From UniProt

complete

involved_in

GO:0042074

cell migration involved in gastrulation

PMID:23884240[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-070427-1

P

Seeded From UniProt

complete

involved_in

GO:0042074

cell migration involved in gastrulation

PMID:23884240[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-130925-15

P

Seeded From UniProt

complete

involved_in

GO:0042074

cell migration involved in gastrulation

PMID:18579679[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081114-4

P

Seeded From UniProt

complete

involved_in

GO:0042074

cell migration involved in gastrulation

PMID:18579679[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081114-3

P

Seeded From UniProt

complete

involved_in

GO:0030239

myofibril assembly

PMID:17517144[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-071022-1

P

Seeded From UniProt

complete

involved_in

GO:0002042

cell migration involved in sprouting angiogenesis

PMID:21429985[7]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110429-2
ZFIN:ZDB-MRPHLNO-110429-3

P

Seeded From UniProt

complete

involved_in

GO:0002042

cell migration involved in sprouting angiogenesis

PMID:21429985[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110429-3

P

Seeded From UniProt

complete

involved_in

GO:0002040

sprouting angiogenesis

PMID:21429983[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-110513-3

P

Seeded From UniProt

complete

involved_in

GO:0001946

lymphangiogenesis

PMID:24903752[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120507-1

P

Seeded From UniProt

complete

involved_in

GO:0001570

vasculogenesis

PMID:19797767[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-091124-3

P

Seeded From UniProt

complete

involved_in

GO:0000902

cell morphogenesis

PMID:18579679[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081114-3

P

Seeded From UniProt

complete

involved_in

GO:0060326

cell chemotaxis

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001200797
UniProtKB:P51684

P

Seeded From UniProt

complete

enables

GO:0019957

C-C chemokine binding

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104616
MGI:MGI:107182
MGI:MGI:1333797
MGI:MGI:1891697
PANTHER:PTN001200797
RGD:708446
UniProtKB:P32246
UniProtKB:P51677
UniProtKB:P51681
UniProtKB:P51684
UniProtKB:P61073

F

Seeded From UniProt

complete

enables

GO:0019956

chemokine binding

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001200797
UniProtKB:P49682
ZFIN:ZDB-GENE-031116-61

F

Seeded From UniProt

complete

involved_in

GO:0019722

calcium-mediated signaling

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001200797
RGD:621528
UniProtKB:P51681
UniProtKB:P51684
UniProtKB:P61073

P

Seeded From UniProt

complete

enables

GO:0016493

C-C chemokine receptor activity

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103011
MGI:MGI:104616
MGI:MGI:104618
MGI:MGI:106185
MGI:MGI:107182
MGI:MGI:107824
MGI:MGI:1096320
MGI:MGI:1201402
MGI:MGI:1333797
MGI:MGI:1341902
MGI:MGI:1891697
PANTHER:PTN001200797
UniProtKB:P32246
UniProtKB:P51681
UniProtKB:P51684

F

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103011
MGI:MGI:103567
MGI:MGI:106185
MGI:MGI:107182
MGI:MGI:107824
MGI:MGI:109563
MGI:MGI:1277207
MGI:MGI:1333797
PANTHER:PTN001200797
RGD:621528
RGD:708446
UniProtKB:P32246
UniProtKB:P51681

C

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1096320
PANTHER:PTN001200797
RGD:1308562
RGD:2906
RGD:620596
RGD:621528
UniProtKB:P32246

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103011
MGI:MGI:106185
PANTHER:PTN001628461
UniProtKB:P32246

P

Seeded From UniProt

complete

involved_in

GO:0006935

chemotaxis

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103011
MGI:MGI:104616
MGI:MGI:107824
MGI:MGI:1096320
MGI:MGI:1201402
MGI:MGI:1333797
MGI:MGI:1341902
MGI:MGI:1346338
PANTHER:PTN001200797
UniProtKB:F1R6D3
UniProtKB:P25025
UniProtKB:P51684
ZFIN:ZDB-GENE-031116-61

P

Seeded From UniProt

complete

involved_in

GO:0070098

chemokine-mediated signaling pathway

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004950

P

Seeded From UniProt

complete

involved_in

GO:0070098

chemokine-mediated signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0016493

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

enables

GO:0004950

chemokine receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000355

F

Seeded From UniProt

complete

involved_in

GO:0006935

chemotaxis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000355

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR000355

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR000355
InterPro:IPR001277
InterPro:IPR017452

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Stückemann, T et al. (2012) Zebrafish Cxcr4a determines the proliferative response to Hedgehog signalling. Development 139 2711-20 PubMed GONUTS page
  2. 2.0 2.1 Boer, EF et al. (2015) Fascin1-dependent Filopodia are required for directional migration of a subset of neural crest cells. PLoS Genet. 11 e1004946 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Lin, CY et al. (2017) modulates an Rtn4a/Cxcr4a/Thbs3a axis in newly forming somites to maintain and stabilize the somite boundary formation of zebrafish embryos. Open Biol 7 PubMed GONUTS page
  4. 4.0 4.1 Chong, SW et al. (2007) The chemokine Sdf-1 and its receptor Cxcr4 are required for formation of muscle in zebrafish. BMC Dev. Biol. 7 54 PubMed GONUTS page
  5. 5.0 5.1 Schmid, B et al. (2013) High-speed panoramic light-sheet microscopy reveals global endodermal cell dynamics. Nat Commun 4 2207 PubMed GONUTS page
  6. 6.0 6.1 6.2 Mizoguchi, T et al. (2008) Sdf1/Cxcr4 signaling controls the dorsal migration of endodermal cells during zebrafish gastrulation. Development 135 2521-9 PubMed GONUTS page
  7. 7.0 7.1 Fujita, M et al. (2011) Assembly and patterning of the vascular network of the vertebrate hindbrain. Development 138 1705-15 PubMed GONUTS page
  8. Bussmann, J et al. (2011) Arterial-venous network formation during brain vascularization involves hemodynamic regulation of chemokine signaling. Development 138 1717-26 PubMed GONUTS page
  9. Astin, JW et al. (2014) Vegfd can compensate for loss of Vegfc in zebrafish facial lymphatic sprouting. Development 141 2680-90 PubMed GONUTS page
  10. Siekmann, AF et al. (2009) Chemokine signaling guides regional patterning of the first embryonic artery. Genes Dev. 23 2272-7 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 11.4 11.5 11.6 11.7 11.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page