GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
DANRE:Q7ZU02
Contents
| Species (Taxon ID) | Danio rerio (Zebrafish) (Brachydanio rerio). (7955) | |
| Gene Name(s) | No Information Provided. | |
| Protein Name(s) | Chemokine (C-X-C motif) receptor 4a (ECO:0000313 with EMBL:AAH50172.1) | |
| External Links | ||
| UniProt | Q7ZU02 | |
| EMBL | BC050172 | |
| RefSeq | NP_571957.2 | |
| UniGene | Dr.84258 | |
| ProteinModelPortal | Q7ZU02 | |
| STRING | 7955.ENSDARP00000074800 | |
| GeneID | 140747 | |
| KEGG | dre:140747 | |
| CTD | 140747 | |
| ZFIN | ZDB-GENE-020102-1 | |
| eggNOG | NOG328039 | |
| HOGENOM | HOG000234122 | |
| HOVERGEN | HBG106917 | |
| KO | K04189 | |
| NextBio | 20797039 | |
| GO | GO:0016021 GO:0016494 GO:0006935 GO:0042119 | |
| InterPro | IPR001277 IPR000355 IPR000276 IPR017452 | |
| PANTHER | PTHR24227 PTHR24227:SF7 | |
| Pfam | PF00001 | |
| PRINTS | PR00657 PR00645 PR00237 | |
| PROSITE | PS00237 PS50262 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0008283 |
cell proliferation |
ECO:0000315 |
P |
Figure 3: Results show that Cxcr4a is essential for endodermal cell proliferation |
complete | |||||
|
involved_in |
GO:0008283 |
cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1903045 |
neural crest cell migration involved in sympathetic nervous system development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-GENE-031009-1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061053 |
somite development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-GENE-030710-1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061053 |
somite development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-GENE-020708-3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061053 |
somite development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-071022-1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060231 |
mesenchymal to epithelial transition |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-GENE-030710-1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060231 |
mesenchymal to epithelial transition |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-GENE-020708-3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060231 |
mesenchymal to epithelial transition |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-071022-1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0055002 |
striated muscle cell development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-071022-1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048703 |
embryonic viscerocranium morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-GENE-031009-1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042074 |
cell migration involved in gastrulation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-070427-1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042074 |
cell migration involved in gastrulation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-130925-15 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042074 |
cell migration involved in gastrulation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-081114-4 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042074 |
cell migration involved in gastrulation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-081114-3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030239 |
myofibril assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-071022-1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002042 |
cell migration involved in sprouting angiogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-110429-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002042 |
cell migration involved in sprouting angiogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-110429-3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002040 |
sprouting angiogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-110513-3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001946 |
lymphangiogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-120507-1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001570 |
vasculogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-091124-3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000902 |
cell morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-081114-3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060326 |
cell chemotaxis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001200797 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019957 |
C-C chemokine binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104616 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019956 |
chemokine binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001200797 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019722 |
calcium-mediated signaling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001200797 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016493 |
C-C chemokine receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103011 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009897 |
external side of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103011 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1096320 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006955 |
immune response |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103011 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006935 |
chemotaxis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103011 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070098 |
chemokine-mediated signaling pathway |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004950 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070098 |
chemokine-mediated signaling pathway |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0016493 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004950 |
chemokine receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006935 |
chemotaxis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000276 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Stückemann, T et al. (2012) Zebrafish Cxcr4a determines the proliferative response to Hedgehog signalling. Development 139 2711-20 PubMed GONUTS page
- ↑ 2.0 2.1 Boer, EF et al. (2015) Fascin1-dependent Filopodia are required for directional migration of a subset of neural crest cells. PLoS Genet. 11 e1004946 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Lin, CY et al. (2017) modulates an Rtn4a/Cxcr4a/Thbs3a axis in newly forming somites to maintain and stabilize the somite boundary formation of zebrafish embryos. Open Biol 7 PubMed GONUTS page
- ↑ 4.0 4.1 Chong, SW et al. (2007) The chemokine Sdf-1 and its receptor Cxcr4 are required for formation of muscle in zebrafish. BMC Dev. Biol. 7 54 PubMed GONUTS page
- ↑ 5.0 5.1 Schmid, B et al. (2013) High-speed panoramic light-sheet microscopy reveals global endodermal cell dynamics. Nat Commun 4 2207 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Mizoguchi, T et al. (2008) Sdf1/Cxcr4 signaling controls the dorsal migration of endodermal cells during zebrafish gastrulation. Development 135 2521-9 PubMed GONUTS page
- ↑ 7.0 7.1 Fujita, M et al. (2011) Assembly and patterning of the vascular network of the vertebrate hindbrain. Development 138 1705-15 PubMed GONUTS page
- ↑ Bussmann, J et al. (2011) Arterial-venous network formation during brain vascularization involves hemodynamic regulation of chemokine signaling. Development 138 1717-26 PubMed GONUTS page
- ↑ Astin, JW et al. (2014) Vegfd can compensate for loss of Vegfc in zebrafish facial lymphatic sprouting. Development 141 2680-90 PubMed GONUTS page
- ↑ Siekmann, AF et al. (2009) Chemokine signaling guides regional patterning of the first embryonic artery. Genes Dev. 23 2272-7 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 11.5 11.6 11.7 11.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
- GO:0016493 ! C-C chemokine receptor activity
- GO:0019957 ! C-C chemokine binding
- GO:0019722 ! calcium-mediated signaling
- GO:0060326 ! cell chemotaxis
- GO:0042074 ! cell migration involved in gastrulation
- GO:0002042 ! cell migration involved in sprouting angiogenesis
- GO:0000902 ! cell morphogenesis
- GO:0008283 ! cell population proliferation
- GO:0070098 ! chemokine-mediated signaling pathway
- GO:0019956 ! chemokine binding
- GO:0004950 ! chemokine receptor activity
- GO:0006935 ! chemotaxis
- Chordata
- Craniata
- Cyprinidae
- Cypriniformes
e
g
m
n
s
