GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:21429985

From GONUTS
Jump to: navigation, search
Citation

Fujita, M, Cha, YR, Pham, VN, Sakurai, A, Roman, BL, Gutkind, JS and Weinstein, BM (2011) Assembly and patterning of the vascular network of the vertebrate hindbrain. Development 138:1705-15

Abstract

The cranial vasculature is essential for the survival and development of the central nervous system and is important in stroke and other brain pathologies. Cranial vessels form in a reproducible and evolutionarily conserved manner, but the process by which these vessels assemble and acquire their stereotypic patterning remains unclear. Here, we examine the stepwise assembly and patterning of the vascular network of the zebrafish hindbrain. The major artery supplying the hindbrain, the basilar artery, runs along the ventral keel of the hindbrain in all vertebrates. We show that this artery forms by a novel process of medial sprouting and migration of endothelial cells from a bilateral pair of primitive veins, the primordial hindbrain channels. Subsequently, a second wave of dorsal sprouting from the primordial hindbrain channels gives rise to angiogenic central arteries that penetrate into and innervate the hindbrain. The chemokine receptor cxcr4a is expressed in migrating endothelial cells of the primordial hindbrain channels, whereas its ligand cxcl12b is expressed in the hindbrain neural keel immediately adjacent to the assembling basilar artery. Knockdown of either cxcl12b or cxcr4a results in defects in basilar artery formation, showing that the assembly and patterning of this crucial artery depends on chemokine signaling.

Links

PubMed PMC3074447 Online version:10.1242/dev.058776

Keywords

Animals; Animals, Genetically Modified; Arteries/embryology; Arteries/metabolism; Arteries/physiology; Blood Vessels/embryology; Blood Vessels/metabolism; Body Patterning/genetics; Body Patterning/physiology; Cells, Cultured; Embryo, Nonmammalian; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; Humans; Models, Biological; Neovascularization, Physiologic/genetics; Neovascularization, Physiologic/physiology; Rhombencephalon/blood supply; Rhombencephalon/embryology; Rhombencephalon/metabolism; Troponin T/genetics; Troponin T/metabolism; Vertebrates/embryology; Vertebrates/genetics; Vertebrates/metabolism; Vertebrates/physiology; Zebrafish/embryology; Zebrafish/genetics; Zebrafish/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:F1QCB2

involved_in

GO:0002042: cell migration involved in sprouting angiogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110429-3

P

Seeded From UniProt

complete

DANRE:F1QCB2

involved_in

GO:0002042: cell migration involved in sprouting angiogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110429-2,ZFIN:ZDB-MRPHLNO-110429-3

P

Seeded From UniProt

complete

DANRE:F8W4X7

involved_in

GO:0002042: cell migration involved in sprouting angiogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110429-3

P

Seeded From UniProt

complete

DANRE:F8W4X7

involved_in

GO:0002042: cell migration involved in sprouting angiogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110429-2,ZFIN:ZDB-MRPHLNO-110429-3

P

Seeded From UniProt

complete

DANRE:Q6V9B5

involved_in

GO:0002042: cell migration involved in sprouting angiogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110429-2

P

Seeded From UniProt

complete

DANRE:Q6V9B5

involved_in

GO:0002042: cell migration involved in sprouting angiogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110429-2,ZFIN:ZDB-MRPHLNO-110429-3

P

Seeded From UniProt

complete

DANRE:Q7ZU02

involved_in

GO:0002042: cell migration involved in sprouting angiogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110429-2,ZFIN:ZDB-MRPHLNO-110429-3

P

Seeded From UniProt

complete

DANRE:Q8UUW8

involved_in

GO:0002042: cell migration involved in sprouting angiogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110429-3

P

Seeded From UniProt

complete

DANRE:Q8UUW8

involved_in

GO:0002042: cell migration involved in sprouting angiogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110429-2,ZFIN:ZDB-MRPHLNO-110429-3

P

Seeded From UniProt

complete

DANRE:Q7ZU02

involved_in

GO:0002042: cell migration involved in sprouting angiogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110429-3

P

Seeded From UniProt

complete

DANRE:Q7ZU02

involved_in

GO:0002042: cell migration involved in sprouting angiogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110429-2
ZFIN:ZDB-MRPHLNO-110429-3

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.