DANRE:Q6RUQ9

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	ift88 (ECO:0000313 with ZFIN:ZDB-GENE-030131-574) (synonyms: ttc10 (ECO:0000313 with ZFIN:ZDB-GENE-030131-574))
Protein Name(s)	Ift88 (ECO:0000313 with EMBL:AAS66768.1)
External Links
UniProt	Q6RUQ9
EMBL	AY491507
RefSeq	NP_001001725.1
UniGene	Dr.2900
ProteinModelPortal	Q6RUQ9
GeneID	321855
KEGG	dre:321855
CTD	8100
ZFIN	ZDB-GENE-030131-574
HOVERGEN	HBG059328
KO	K16474
PhylomeDB	Q6RUQ9
NextBio	20807557
Gene3D	1.25.40.10
InterPro	IPR006597 IPR013026 IPR011990 IPR013105 IPR019734
Pfam	PF07719 PF13174 PF13181
SMART	SM00671 SM00028
PROSITE	PS50005 PS50293

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:1905515	non-motile cilium assembly	PMID:15182712^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980410-147	P	Seeded From UniProt	complete
involved_in	GO:0072019	proximal convoluted tubule development	PMID:19127979^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050506-2	P	Seeded From UniProt	complete
involved_in	GO:0071482	cellular response to light stimulus	PMID:22485131^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080730-2	P	Seeded From UniProt	complete
involved_in	GO:0060785	regulation of apoptosis involved in tissue homeostasis	PMID:22485131^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080730-2	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:27207957^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-160908-10	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:25838181^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050506-2	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:24743595^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050506-1	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:19700616^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-110203-15	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:19517571^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050513-1	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:19517571^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080730-2	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:18492793^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080730-2	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:18364699^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080730-2	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:16216239^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060111-1	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:15790966^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050506-1	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:15790966^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980410-147	P	Seeded From UniProt	complete
involved_in	GO:0060122	inner ear receptor cell stereocilium organization	PMID:24626987^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045880	positive regulation of smoothened signaling pathway	PMID:19700616^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-110203-15	P	Seeded From UniProt	complete
involved_in	GO:0045494	photoreceptor cell maintenance	PMID:22485131^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080730-2	P	Seeded From UniProt	complete
involved_in	GO:0045494	photoreceptor cell maintenance	PMID:15182712^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980410-147	P	Seeded From UniProt	complete
involved_in	GO:0042462	eye photoreceptor cell development	PMID:18492793^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050513-1	P	Seeded From UniProt	complete
involved_in	GO:0042462	eye photoreceptor cell development	PMID:18492793^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080730-2	P	Seeded From UniProt	complete
involved_in	GO:0042462	eye photoreceptor cell development	PMID:15182712^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980410-147	P	Seeded From UniProt	complete
involved_in	GO:0042073	intraciliary transport	PMID:18492793^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050513-1	P	Seeded From UniProt	complete
involved_in	GO:0042073	intraciliary transport	PMID:18492793^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080730-2	P	Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	PMID:18492793^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	PMID:18304522^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007369	gastrulation	PMID:22941275^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050513-2	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:18056639^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050506-1 ZFIN:ZDB-MRPHLNO-050830-1	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:18056639^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-080301-1 ZFIN:ZDB-MRPHLNO-050830-1	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:16216239^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060111-1	P	Seeded From UniProt	complete
part_of	GO:0005930	axoneme	PMID:18304522^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:16216239^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0003351	epithelial cilium movement	PMID:15790966^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050506-1	P	Seeded From UniProt	complete
involved_in	GO:0003351	epithelial cilium movement	PMID:15790966^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980410-147	P	Seeded From UniProt	complete
involved_in	GO:0000132	establishment of mitotic spindle orientation	PMID:24095732^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-120510-4	P	Seeded From UniProt	complete
involved_in	GO:0000132	establishment of mitotic spindle orientation	PMID:21441926^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050506-1	P	Seeded From UniProt	complete
involved_in	GO:1905515	non-motile cilium assembly	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0016919 MGI:MGI:98715 PANTHER:PTN000555524 WB:WBGene00003885	P	Seeded From UniProt	complete
part_of	GO:0097730	non-motile cilium	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0016919 MGI:MGI:98715 PANTHER:PTN000555524 WB:WBGene00003885	C	Seeded From UniProt	complete
part_of	GO:0097546	ciliary base	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98715 PANTHER:PTN000555524	C	Seeded From UniProt	complete
involved_in	GO:0060122	inner ear receptor cell stereocilium organization	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98715 PANTHER:PTN002891187	P	Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98715 PANTHER:PTN000555524 UniProtKB:Q13099 WB:WBGene00003885	C	Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98715 PANTHER:PTN000555524	F	Seeded From UniProt	complete
part_of	GO:0005814	centriole	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98715 PANTHER:PTN000555524 UniProtKB:Q13099	C	Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98715 PANTHER:PTN002891187	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Tsujikawa, M & Malicki, J (2004) Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons. Neuron 42 703-16 PubMed GONUTS page
↑ Vasilyev, A et al. (2009) Collective cell migration drives morphogenesis of the kidney nephron. PLoS Biol. 7 e9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Nakao, T et al. (2012) The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa. PLoS ONE 7 e32472 PubMed GONUTS page
↑ Stawicki, TM et al. (2016) Cilia-Associated Genes Play Differing Roles in Aminoglycoside-Induced Hair Cell Death in Zebrafish. G3 (Bethesda) 6 2225-35 PubMed GONUTS page
↑ Oltrabella, F et al. (2015) The Lowe syndrome protein OCRL1 is required for endocytosis in the zebrafish pronephric tubule. PLoS Genet. 11 e1005058 PubMed GONUTS page
↑ Pathak, N et al. (2014) Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function. Mol. Biol. Cell 25 1836-44 PubMed GONUTS page
↑ ^7.0 ^7.1 Huang, P & Schier, AF (2009) Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia. Development 136 3089-98 PubMed GONUTS page
↑ ^8.0 ^8.1 Lunt, SC et al. (2009) Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling. Dev. Dyn. 238 1744-59 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Krock, BL & Perkins, BD (2008) The intraflagellar transport protein IFT57 is required for cilia maintenance and regulates IFT-particle-kinesin-II dissociation in vertebrate photoreceptors. J. Cell. Sci. 121 1907-15 PubMed GONUTS page
↑ Omori, Y et al. (2008) Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8. Nat. Cell Biol. 10 437-44 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Bisgrove, BW et al. (2005) Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis. Dev. Biol. 287 274-88 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Kramer-Zucker, AG et al. (2005) Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis. Development 132 1907-21 PubMed GONUTS page
↑ Blanco-Sánchez, B et al. (2014) Complexes of Usher proteins preassemble at the endoplasmic reticulum and are required for trafficking and ER homeostasis. Dis Model Mech 7 547-59 PubMed GONUTS page
↑ ^14.0 ^14.1 Insinna, C et al. (2008) The homodimeric kinesin, Kif17, is essential for vertebrate photoreceptor sensory outer segment development. Dev. Biol. 316 160-70 PubMed GONUTS page
↑ McIntyre, JC et al. (2012) Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model. Nat. Med. 18 1423-8 PubMed GONUTS page
↑ ^16.0 ^16.1 Sarmah, B et al. (2007) A role for the inositol kinase Ipk1 in ciliary beating and length maintenance. Proc. Natl. Acad. Sci. U.S.A. 104 19843-8 PubMed GONUTS page
↑ Borovina, A & Ciruna, B (2013) IFT88 plays a cilia- and PCP-independent role in controlling oriented cell divisions during vertebrate embryonic development. Cell Rep 5 37-43 PubMed GONUTS page
↑ Delaval, B et al. (2011) The cilia protein IFT88 is required for spindle orientation in mitosis. Nat. Cell Biol. 13 461-8 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 ^19.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15182712-1] 1.0 ^1.1 ^1.2 Tsujikawa, M & Malicki, J (2004) Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons. Neuron 42 703-16 PubMed GONUTS page

[PMID:19127979-2] Vasilyev, A et al. (2009) Collective cell migration drives morphogenesis of the kidney nephron. PLoS Biol. 7 e9 PubMed GONUTS page

[PMID:22485131-3] 3.0 ^3.1 ^3.2 Nakao, T et al. (2012) The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa. PLoS ONE 7 e32472 PubMed GONUTS page

[PMID:27207957-4] Stawicki, TM et al. (2016) Cilia-Associated Genes Play Differing Roles in Aminoglycoside-Induced Hair Cell Death in Zebrafish. G3 (Bethesda) 6 2225-35 PubMed GONUTS page

[PMID:25838181-5] Oltrabella, F et al. (2015) The Lowe syndrome protein OCRL1 is required for endocytosis in the zebrafish pronephric tubule. PLoS Genet. 11 e1005058 PubMed GONUTS page

[PMID:24743595-6] Pathak, N et al. (2014) Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function. Mol. Biol. Cell 25 1836-44 PubMed GONUTS page

[PMID:19700616-7] 7.0 ^7.1 Huang, P & Schier, AF (2009) Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia. Development 136 3089-98 PubMed GONUTS page

[PMID:19517571-8] 8.0 ^8.1 Lunt, SC et al. (2009) Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling. Dev. Dyn. 238 1744-59 PubMed GONUTS page

[PMID:18492793-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Krock, BL & Perkins, BD (2008) The intraflagellar transport protein IFT57 is required for cilia maintenance and regulates IFT-particle-kinesin-II dissociation in vertebrate photoreceptors. J. Cell. Sci. 121 1907-15 PubMed GONUTS page

[PMID:18364699-10] Omori, Y et al. (2008) Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8. Nat. Cell Biol. 10 437-44 PubMed GONUTS page

[PMID:16216239-11] 11.0 ^11.1 ^11.2 Bisgrove, BW et al. (2005) Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis. Dev. Biol. 287 274-88 PubMed GONUTS page

[PMID:15790966-12] 12.0 ^12.1 ^12.2 ^12.3 Kramer-Zucker, AG et al. (2005) Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis. Development 132 1907-21 PubMed GONUTS page

[PMID:24626987-13] Blanco-Sánchez, B et al. (2014) Complexes of Usher proteins preassemble at the endoplasmic reticulum and are required for trafficking and ER homeostasis. Dis Model Mech 7 547-59 PubMed GONUTS page

[PMID:18304522-14] 14.0 ^14.1 Insinna, C et al. (2008) The homodimeric kinesin, Kif17, is essential for vertebrate photoreceptor sensory outer segment development. Dev. Biol. 316 160-70 PubMed GONUTS page

[PMID:22941275-15] McIntyre, JC et al. (2012) Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model. Nat. Med. 18 1423-8 PubMed GONUTS page

[PMID:18056639-16] 16.0 ^16.1 Sarmah, B et al. (2007) A role for the inositol kinase Ipk1 in ciliary beating and length maintenance. Proc. Natl. Acad. Sci. U.S.A. 104 19843-8 PubMed GONUTS page

[PMID:24095732-17] Borovina, A & Ciruna, B (2013) IFT88 plays a cilia- and PCP-independent role in controlling oriented cell divisions during vertebrate embryonic development. Cell Rep 5 37-43 PubMed GONUTS page

[PMID:21441926-18] Delaval, B et al. (2011) The cilia protein IFT88 is required for spindle orientation in mitosis. Nat. Cell Biol. 13 461-8 PubMed GONUTS page

[PMID:21873635-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 ^19.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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DANRE:Q6RUQ9

Contents

Annotations

Notes

References

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