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DANRE:Q6IVV8

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) No Information Provided.
Protein Name(s) PKD2 (ECO:0000313 with EMBL:AAT39122.1)

Uncharacterized protein (ECO:0000313 with Ensembl:ENSDARP00000027024)

External Links
UniProt Q6IVV8
EMBL CR788312
AY618926
RefSeq NP_001002310.1
UniGene Dr.92211
Ensembl ENSDART00000020412
GeneID 432387
KEGG dre:432387
CTD 5311
ZFIN ZDB-GENE-040827-4
GeneTree ENSGT00700000104221
HOVERGEN HBG014945
KO K04986
OMA AWSRDNP
OrthoDB EOG7N8ZTW
PhylomeDB Q6IVV8
TreeFam TF316484
NextBio 20831024
PRO PR:Q6IVV8
Proteomes UP000000437
GO GO:0016323
GO:0005929
GO:0005783
GO:0016328
GO:0005262
GO:0005509
GO:0070588
GO:0050982
GO:0007368
GO:0009953
GO:0003143
GO:0003146
GO:0001947
GO:0001822
GO:0001946
GO:0048793
GO:0072114
GO:0072019
GO:0010882
GO:0032965
Gene3D 1.10.238.10
InterPro IPR011992
IPR002048
IPR013122
IPR003915
Pfam PF08016
PRINTS PR01433
PROSITE PS50222

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0072019

PMID:15269167[1]

IMP: Inferred from Mutant Phenotype

Table 1, Table 2, and Figure 1

complete
CACAO 3492

GO:0001822

kidney development

PMID:24235270[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060630-4

P

Seeded From UniProt

complete

GO:0001946

lymphangiogenesis

PMID:24767999[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070129-1

P

Seeded From UniProt

complete

GO:0001947

heart looping

PMID:18417723[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070129-3

P

Seeded From UniProt

complete

GO:0001947

heart looping

PMID:9334285[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003143

embryonic heart tube morphogenesis

PMID:9334285[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003146

heart jogging

PMID:9334285[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0005262

calcium channel activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000093539

F

Seeded From UniProt

complete

GO:0005509

calcium ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002048
InterPro:IPR003915

F

Seeded From UniProt

complete

GO:0005783

endoplasmic reticulum

PMID:18417723[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005783

endoplasmic reticulum

PMID:19801576[6]

ISS: Inferred from Sequence or Structural Similarity

RefSeq:NM_000297.3

C

Seeded From UniProt

complete

GO:0005929

cilium

PMID:18417723[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005929

cilium

PMID:18701462[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:16943304[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070129-2

P

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:17360770[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1193

P

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:17360770[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-870

P

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:17360770[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070620-5

P

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:17360770[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070620-6

P

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:18417723[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070129-3

P

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:20168298[10]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060630-4

P

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:21490950[11]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-060630-4
ZFIN:ZDB-MRPHLNO-110527-1

P

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:25660539[12]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-040830-2

P

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:25660539[12]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060630-4

P

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:9334285[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009953

dorsal/ventral pattern formation

PMID:19488022[13]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060630-4

P

Seeded From UniProt

complete

GO:0010882

regulation of cardiac muscle contraction by calcium ion signaling

PMID:23376035[14]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-100715-11

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003915

C

Seeded From UniProt

complete

GO:0016323

basolateral plasma membrane

PMID:18417723[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016323

basolateral plasma membrane

PMID:18701462[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016328

lateral plasma membrane

PMID:16551655[15]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q13563

C

Seeded From UniProt

complete

GO:0032965

regulation of collagen biosynthetic process

PMID:20335443[16]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070129-4

P

Seeded From UniProt

complete

GO:0048793

pronephros development

PMID:16943304[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070129-2

P

Seeded From UniProt

complete

GO:0048793

pronephros development

PMID:18417723[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070129-3

P

Seeded From UniProt

complete

GO:0048793

pronephros development

PMID:18695040[17]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070129-2

P

Seeded From UniProt

complete

GO:0048793

pronephros development

PMID:19801576[6]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-040426-770

P

Seeded From UniProt

complete

GO:0048793

pronephros development

PMID:19801576[6]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-070129-2
ZFIN:ZDB-MRPHLNO-100224-1

P

Seeded From UniProt

complete

GO:0048793

pronephros development

PMID:20729296[18]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-060630-4
ZFIN:ZDB-MRPHLNO-101122-2

P

Seeded From UniProt

complete

GO:0048793

pronephros development

PMID:21752935[19]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-060630-4
ZFIN:ZDB-MRPHLNO-100823-10

P

Seeded From UniProt

complete

GO:0048793

pronephros development

PMID:21752935[19]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060630-4

P

Seeded From UniProt

complete

GO:0050982

detection of mechanical stimulus

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000093539

P

Seeded From UniProt

complete

GO:0061371

determination of heart left/right asymmetry

PMID:25660539[12]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-040830-2

P

Seeded From UniProt

complete

GO:0061371

determination of heart left/right asymmetry

PMID:25660539[12]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060630-4

P

Seeded From UniProt

complete

GO:0070588

calcium ion transmembrane transport

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000093539

P

Seeded From UniProt

complete

GO:0072019

proximal convoluted tubule development

PMID:19127979[20]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070129-4

P

Seeded From UniProt

complete

GO:0072114

pronephros morphogenesis

PMID:20168298[10]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060630-4

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Sun, Z et al. (2004) A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney. Development 131 4085-93 PubMed GONUTS page
  2. Aboualaiwi, WA et al. (2014) Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation. Circulation 129 660-72 PubMed GONUTS page
  3. Coxam, B et al. (2014) Pkd1 regulates lymphatic vascular morphogenesis during development. Cell Rep 7 623-33 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Fu, X et al. (2008) The subcellular localization of TRPP2 modulates its function. J. Am. Soc. Nephrol. 19 1342-51 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Chen, JN et al. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124 4373-82 PubMed GONUTS page
  6. 6.0 6.1 6.2 Gao, H et al. (2010) PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation. Hum. Mol. Genet. 19 16-24 PubMed GONUTS page
  7. 7.0 7.1 Feng, S et al. (2008) Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2. J. Biol. Chem. 283 28471-9 PubMed GONUTS page
  8. 8.0 8.1 Obara, T et al. (2006) Polycystin-2 immunolocalization and function in zebrafish. J. Am. Soc. Nephrol. 17 2706-18 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 Schottenfeld, J et al. (2007) Zebrafish curly up encodes a Pkd2 ortholog that restricts left-side-specific expression of southpaw. Development 134 1605-15 PubMed GONUTS page
  10. 10.0 10.1 Giamarchi, A et al. (2010) A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 29 1176-91 PubMed GONUTS page
  11. Fogelgren, B et al. (2011) The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes. PLoS Genet. 7 e1001361 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 Yuan, S et al. (2015) Intraciliary calcium oscillations initiate vertebrate left-right asymmetry. Curr. Biol. 25 556-67 PubMed GONUTS page
  13. Yuan, S & Sun, Z (2009) Microinjection of mRNA and morpholino antisense oligonucleotides in zebrafish embryos. J Vis Exp PubMed GONUTS page
  14. Paavola, J et al. (2013) Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy. J. Mol. Cell. Cardiol. 58 199-208 PubMed GONUTS page
  15. Streets, AJ et al. (2006) Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro. Hum. Mol. Genet. 15 1465-73 PubMed GONUTS page
  16. Mangos, S et al. () The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation. Dis Model Mech 3 354-65 PubMed GONUTS page
  17. Köttgen, M et al. (2008) TRPP2 and TRPV4 form a polymodal sensory channel complex. J. Cell Biol. 182 437-47 PubMed GONUTS page
  18. Hurd, T et al. (2010) The retinitis pigmentosa protein RP2 interacts with polycystin 2 and regulates cilia-mediated vertebrate development. Hum. Mol. Genet. 19 4330-44 PubMed GONUTS page
  19. 19.0 19.1 Rothschild, SC et al. (2011) CaMK-II is a PKD2 target that promotes pronephric kidney development and stabilizes cilia. Development 138 3387-97 PubMed GONUTS page
  20. Vasilyev, A et al. (2009) Collective cell migration drives morphogenesis of the kidney nephron. PLoS Biol. 7 e9 PubMed GONUTS page