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DANRE:Q1KHF9
Contents
| Species (Taxon ID) | Danio rerio (Zebrafish) (Brachydanio rerio). (7955) | |
| Gene Name(s) | No Information Provided. (synonyms: furinA (ECO:0000313 with EMBL:ABF18688.1)) | |
| Protein Name(s) | Furin (Paired basic amino acid cleaving enzyme) a (ECO:0000313 with EMBL:AAI39880.1)
FurinA preproprotein (ECO:0000313 with EMBL:ABF18688.1) | |
| External Links | ||
| UniProt | Q1KHF9 | |
| EMBL | BC139879 DQ499476 | |
| RefSeq | NP_001038571.1 | |
| UniGene | Dr.80554 | |
| SMR | Q1KHF9 | |
| MEROPS | S08.152 | |
| GeneID | 566557 | |
| KEGG | dre:566557 | |
| CTD | 566557 | |
| ZFIN | ZDB-GENE-040901-1 | |
| HOGENOM | HOG000192536 | |
| HOVERGEN | HBG008705 | |
| KO | K01349 | |
| PhylomeDB | Q1KHF9 | |
| NextBio | 20888251 | |
| GO | GO:0005615 GO:0005794 GO:0004252 GO:0051216 GO:0060536 GO:0048703 GO:0033334 | |
| Gene3D | 2.60.120.260 3.40.50.200 | |
| InterPro | IPR006212 IPR008979 IPR009030 IPR000209 IPR023827 IPR022398 IPR023828 IPR015500 IPR009020 IPR002884 | |
| PANTHER | PTHR10795 | |
| Pfam | PF01483 PF00082 | |
| PRINTS | PR00723 | |
| SMART | SM00261 | |
| SUPFAM | SSF49785 SSF52743 SSF54897 SSF57184 | |
| PROSITE | PS00136 PS00137 PS00138 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0060536 |
cartilage morphogenesis |
ECO:0000316 |
|
P |
Particularly striking is the similarity of alcama morphants to furinA−/− mutants (Fig. 2 E). |
complete | ||||
|
involved_in |
GO:0060536 |
cartilage morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071907 |
determination of digestive tract left/right asymmetry |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-150626-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061371 |
determination of heart left/right asymmetry |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-150626-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060536 |
cartilage morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-980202-1487 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060536 |
cartilage morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-980202-1065 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051216 |
cartilage development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-GENO-980202-1065 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051216 |
cartilage development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-GENO-980202-1065 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051216 |
cartilage development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-060822-5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051216 |
cartilage development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-980202-1065 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048703 |
embryonic viscerocranium morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-980202-1487 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0033334 |
fin morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-980202-1487 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009617 |
response to bacterium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-140403-1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0003146 |
heart jogging |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-150626-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0003140 |
determination of left/right asymmetry in lateral mesoderm |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-150626-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001947 |
heart looping |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-150626-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001947 |
heart looping |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-100813-3 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030173 |
integral component of Golgi membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000082856 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016486 |
peptide hormone processing |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97515 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016485 |
protein processing |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0023179 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004509 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005802 |
trans-Golgi network |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000082856 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004509 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008236 |
serine-type peptidase activity |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Choudhry, P et al. (2011) Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis. Dev. Biol. 349 483-93 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Tessadori, F et al. (2015) Nodal signaling range is regulated by proprotein convertase-mediated maturation. Dev. Cell 32 631-9 PubMed GONUTS page
- ↑ 3.0 3.1 Piotrowski, T et al. (1996) Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation. Development 123 345-56 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Walker, MB et al. (2006) Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning. Dev. Biol. 295 194-205 PubMed GONUTS page
- ↑ Carney, TJ et al. (2010) Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes. PLoS Genet. 6 e1000907 PubMed GONUTS page
- ↑ Ojanen, MJ et al. (2015) The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum. Infect. Immun. 83 1431-42 PubMed GONUTS page
- ↑ Smith, KA et al. (2009) Dominant-negative ALK2 allele associates with congenital heart defects. Circulation 119 3062-9 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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