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DANRE:Q1KHF9

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) No Information Provided. (synonyms: furinA (ECO:0000313 with EMBL:ABF18688.1))
Protein Name(s) Furin (Paired basic amino acid cleaving enzyme) a (ECO:0000313 with EMBL:AAI39880.1)

FurinA preproprotein (ECO:0000313 with EMBL:ABF18688.1)

External Links
UniProt Q1KHF9
EMBL BC139879
DQ499476
RefSeq NP_001038571.1
UniGene Dr.80554
SMR Q1KHF9
MEROPS S08.152
GeneID 566557
KEGG dre:566557
CTD 566557
ZFIN ZDB-GENE-040901-1
HOGENOM HOG000192536
HOVERGEN HBG008705
KO K01349
PhylomeDB Q1KHF9
NextBio 20888251
GO GO:0005615
GO:0005794
GO:0004252
GO:0051216
GO:0060536
GO:0048703
GO:0033334
Gene3D 2.60.120.260
3.40.50.200
InterPro IPR006212
IPR008979
IPR009030
IPR000209
IPR023827
IPR022398
IPR023828
IPR015500
IPR009020
IPR002884
PANTHER PTHR10795
Pfam PF01483
PF00082
PRINTS PR00723
SMART SM00261
SUPFAM SSF49785
SSF52743
SSF54897
SSF57184
PROSITE PS00136
PS00137
PS00138

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0060536

cartilage morphogenesis

PMID:21073867[1]

IGI: Inferred from Genetic Interaction

UniProtKB:Q90460


P

Particularly striking is the similarity of alcama morphants to furinA−/− mutants (Fig. 2 E).

complete
CACAO 2069

GO:0001947

heart looping

PMID:19506109[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-100813-3

P

Seeded From UniProt

complete

GO:0001947

heart looping

PMID:25684355[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-150626-2

P

Seeded From UniProt

complete

GO:0003140

determination of left/right asymmetry in lateral mesoderm

PMID:25684355[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-150626-2

P

Seeded From UniProt

complete

GO:0003146

heart jogging

PMID:25684355[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-150626-2

P

Seeded From UniProt

complete

GO:0004252

serine-type endopeptidase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000209
InterPro:IPR002884

F

Seeded From UniProt

complete

GO:0004252

serine-type endopeptidase activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000082845

F

Seeded From UniProt

complete

GO:0005615

extracellular space

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000082930

C

Seeded From UniProt

complete

GO:0006508

proteolysis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000209
InterPro:IPR002884

P

Seeded From UniProt

complete

GO:0006508

proteolysis

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

GO:0008233

peptidase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

GO:0008236

serine-type peptidase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0720

F

Seeded From UniProt

complete

GO:0009617

response to bacterium

PMID:25624351[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-140403-1

P

Seeded From UniProt

complete

GO:0016485

protein processing

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000082856

P

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0033334

fin morphogenesis

PMID:20419147[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1487

P

Seeded From UniProt

complete

GO:0048703

embryonic viscerocranium morphogenesis

PMID:21073867[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1487

P

Seeded From UniProt

complete

GO:0051216

cartilage development

PMID:16678149[6]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-980202-1065
ZFIN:ZDB-GENO-980202-1068

P

Seeded From UniProt

complete

GO:0051216

cartilage development

PMID:16678149[6]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-980202-1065
ZFIN:ZDB-MRPHLNO-060822-3

P

Seeded From UniProt

complete

GO:0051216

cartilage development

PMID:16678149[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1065

P

Seeded From UniProt

complete

GO:0051216

cartilage development

PMID:16678149[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060822-5

P

Seeded From UniProt

complete

GO:0060536

cartilage morphogenesis

PMID:21073867[1]

IGI: Inferred from Genetic Interaction

UniProtKB:Q90460

P

Seeded From UniProt

complete

GO:0060536

cartilage morphogenesis

PMID:9007254[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1065

P

Seeded From UniProt

complete

GO:0060536

cartilage morphogenesis

PMID:9007254[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1487

P

Seeded From UniProt

complete

GO:0061371

determination of heart left/right asymmetry

PMID:25684355[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-150626-2

P

Seeded From UniProt

complete

GO:0071907

determination of digestive tract left/right asymmetry

PMID:25684355[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-150626-2

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Choudhry, P et al. (2011) Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis. Dev. Biol. 349 483-93 PubMed GONUTS page
  2. Smith, KA et al. (2009) Dominant-negative ALK2 allele associates with congenital heart defects. Circulation 119 3062-9 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Tessadori, F et al. (2015) Nodal signaling range is regulated by proprotein convertase-mediated maturation. Dev. Cell 32 631-9 PubMed GONUTS page
  4. Ojanen, MJ et al. (2015) The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum. Infect. Immun. 83 1431-42 PubMed GONUTS page
  5. Carney, TJ et al. (2010) Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes. PLoS Genet. 6 e1000907 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Walker, MB et al. (2006) Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning. Dev. Biol. 295 194-205 PubMed GONUTS page
  7. 7.0 7.1 Piotrowski, T et al. (1996) Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation. Development 123 345-56 PubMed GONUTS page