DANRE:Q08CI2

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	foxj1a
Protein Name(s)	Forkhead box J1a Foxj1a protein
External Links
UniProt	Q08CI2
EMBL	BC124228 BC164538
UniGene	Dr.79389
ZFIN	ZDB-GENE-060929-1178
HOVERGEN	HBG056832
InParanoid	Q08CI2
GO	GO:0005634 GO:0005667 GO:0008301 GO:0003690 GO:0003705 GO:0043565 GO:0008134 GO:0030036 GO:0032862 GO:0042384 GO:0060271 GO:0007368 GO:0030855 GO:0003351 GO:0035089 GO:0003146 GO:0001947 GO:0060972 GO:0050900 GO:0030324 GO:0050869 GO:0002635 GO:0002924 GO:0045409 GO:0032088 GO:0033085 GO:0042130 GO:0000122 GO:0002897 GO:0060296 GO:0009611 GO:0006366
Gene3D	1.10.10.10
InterPro	IPR001766 IPR018122 IPR011991
Pfam	PF00250
PRINTS	PR00053
SMART	SM00339
PROSITE	PS00657 PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0060296	regulation of cilium beat frequency involved in ciliary motility	PMID:20937855^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-101117-1 ZFIN:ZDB-MRPHLNO-101117-2	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:26327644^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090409-2	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:25448689^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090409-2	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:19011630^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090409-2	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:19011629^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090213-1	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:20876649^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:20014402^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:19011630^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	PMID:20937855^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-101117-1 ZFIN:ZDB-MRPHLNO-101117-2	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:26327644^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090409-2	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:19284996^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090513-1	P	Seeded From UniProt	complete
involved_in	GO:0003351	epithelial cilium movement	PMID:20937855^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-101117-1 ZFIN:ZDB-MRPHLNO-101117-2	P	Seeded From UniProt	complete
involved_in	GO:0003146	heart jogging	PMID:19284996^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090513-1	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:19284996^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090513-1	P	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
involved_in	GO:0030030	cell projection organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0970	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Hellman, NE et al. (2010) The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch. Proc. Natl. Acad. Sci. U.S.A. 107 18499-504 PubMed GONUTS page
↑ ^2.0 ^2.1 Dutta, S et al. (2015) nlz1 is required for cilia formation in zebrafish embryogenesis. Dev. Biol. 406 203-11 PubMed GONUTS page
↑ Lu, H et al. (2015) A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation. Dev. Biol. 397 225-36 PubMed GONUTS page
↑ ^4.0 ^4.1 Yu, X et al. (2008) Foxj1 transcription factors are master regulators of the motile ciliogenic program. Nat. Genet. 40 1445-53 PubMed GONUTS page
↑ Stubbs, JL et al. (2008) The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos. Nat. Genet. 40 1454-60 PubMed GONUTS page
↑ Lopes, SS et al. (2010) Notch signalling regulates left-right asymmetry through ciliary length control. Development 137 3625-32 PubMed GONUTS page
↑ Tay, SY et al. (2010) The iguana/DZIP1 protein is a novel component of the ciliogenic pathway essential for axonemal biogenesis. Dev. Dyn. 239 527-34 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Tian, T et al. (2009) Both foxj1a and foxj1b are implicated in left-right asymmetric development in zebrafish embryos. Biochem. Biophys. Res. Commun. 380 537-42 PubMed GONUTS page

[PMID:20937855-1] 1.0 ^1.1 ^1.2 Hellman, NE et al. (2010) The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch. Proc. Natl. Acad. Sci. U.S.A. 107 18499-504 PubMed GONUTS page

[PMID:26327644-2] 2.0 ^2.1 Dutta, S et al. (2015) nlz1 is required for cilia formation in zebrafish embryogenesis. Dev. Biol. 406 203-11 PubMed GONUTS page

[PMID:25448689-3] Lu, H et al. (2015) A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation. Dev. Biol. 397 225-36 PubMed GONUTS page

[PMID:19011630-4] 4.0 ^4.1 Yu, X et al. (2008) Foxj1 transcription factors are master regulators of the motile ciliogenic program. Nat. Genet. 40 1445-53 PubMed GONUTS page

[PMID:19011629-5] Stubbs, JL et al. (2008) The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos. Nat. Genet. 40 1454-60 PubMed GONUTS page

[PMID:20876649-6] Lopes, SS et al. (2010) Notch signalling regulates left-right asymmetry through ciliary length control. Development 137 3625-32 PubMed GONUTS page

[PMID:20014402-7] Tay, SY et al. (2010) The iguana/DZIP1 protein is a novel component of the ciliogenic pathway essential for axonemal biogenesis. Dev. Dyn. 239 527-34 PubMed GONUTS page

[PMID:19284996-8] 8.0 ^8.1 ^8.2 Tian, T et al. (2009) Both foxj1a and foxj1b are implicated in left-right asymmetric development in zebrafish embryos. Biochem. Biophys. Res. Commun. 380 537-42 PubMed GONUTS page

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DANRE:Q08CI2

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