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DANRE:Q08CI2

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) foxj1a
Protein Name(s) Forkhead box J1a

Foxj1a protein

External Links
UniProt Q08CI2
EMBL BC124228
BC164538
UniGene Dr.79389
ZFIN ZDB-GENE-060929-1178
HOVERGEN HBG056832
InParanoid Q08CI2
GO GO:0005634
GO:0005667
GO:0008301
GO:0003690
GO:0003705
GO:0043565
GO:0008134
GO:0030036
GO:0032862
GO:0042384
GO:0060271
GO:0007368
GO:0030855
GO:0003351
GO:0035089
GO:0003146
GO:0001947
GO:0060972
GO:0050900
GO:0030324
GO:0050869
GO:0002635
GO:0002924
GO:0045409
GO:0032088
GO:0033085
GO:0042130
GO:0000122
GO:0002897
GO:0060296
GO:0009611
GO:0006366
Gene3D 1.10.10.10
InterPro IPR001766
IPR018122
IPR011991
Pfam PF00250
PRINTS PR00053
SMART SM00339
PROSITE PS00657
PS00658
PS50039

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001947

heart looping

PMID:19284996[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-090513-1

P

Seeded From UniProt

complete

GO:0002635

negative regulation of germinal center formation

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215343

P

Seeded From UniProt

complete

GO:0002897

positive regulation of central B cell tolerance induction

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215343

P

Seeded From UniProt

complete

GO:0002924

negative regulation of humoral immune response mediated by circulating immunoglobulin

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215343

P

Seeded From UniProt

complete

GO:0003146

heart jogging

PMID:19284996[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-090513-1

P

Seeded From UniProt

complete

GO:0003351

epithelial cilium movement

PMID:20937855[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-101117-1
ZFIN:ZDB-MRPHLNO-101117-2

P

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0003690

double-stranded DNA binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215024

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001766
InterPro:IPR018122

F

Seeded From UniProt

complete

GO:0003705

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215024

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005667

transcription factor complex

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215024

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001766
InterPro:IPR018122

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:19284996[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-090513-1

P

Seeded From UniProt

complete

GO:0008134

transcription factor binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215024

F

Seeded From UniProt

complete

GO:0008301

DNA binding, bending

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215025

F

Seeded From UniProt

complete

GO:0009611

response to wounding

PMID:20937855[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-101117-1
ZFIN:ZDB-MRPHLNO-101117-2

P

Seeded From UniProt

complete

GO:0019904

protein domain specific binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215248

F

Seeded From UniProt

complete

GO:0030036

actin cytoskeleton organization

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215341

P

Seeded From UniProt

complete

GO:0030324

lung development

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215343

P

Seeded From UniProt

complete

GO:0030855

epithelial cell differentiation

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215343

P

Seeded From UniProt

complete

GO:0032088

negative regulation of NF-kappaB transcription factor activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215343

P

Seeded From UniProt

complete

GO:0032862

activation of Rho GTPase activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215341

P

Seeded From UniProt

complete

GO:0033085

negative regulation of T cell differentiation in thymus

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215343

P

Seeded From UniProt

complete

GO:0035089

establishment of apical/basal cell polarity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215341

P

Seeded From UniProt

complete

GO:0042130

negative regulation of T cell proliferation

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215343

P

Seeded From UniProt

complete

GO:0042384

cilium assembly

PMID:19011629[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-090213-1

P

Seeded From UniProt

complete

GO:0042384

cilium assembly

PMID:19011630[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-090409-2

P

Seeded From UniProt

complete

GO:0042384

cilium assembly

PMID:20876649[5]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001766
InterPro:IPR018122

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

PMID:19011630[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0045409

negative regulation of interleukin-6 biosynthetic process

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215343

P

Seeded From UniProt

complete

GO:0050869

negative regulation of B cell activation

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215343

P

Seeded From UniProt

complete

GO:0050900

leukocyte migration

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215343

P

Seeded From UniProt

complete

GO:0060271

cilium morphogenesis

PMID:20014402[6]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0060296

regulation of cilium beat frequency involved in ciliary motility

PMID:20937855[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-101117-1
ZFIN:ZDB-MRPHLNO-101117-2

P

Seeded From UniProt

complete

GO:0060972

left/right pattern formation

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000215341

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Tian, T et al. (2009) Both foxj1a and foxj1b are implicated in left-right asymmetric development in zebrafish embryos. Biochem. Biophys. Res. Commun. 380 537-42 PubMed GONUTS page
  2. 2.0 2.1 2.2 Hellman, NE et al. (2010) The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch. Proc. Natl. Acad. Sci. U.S.A. 107 18499-504 PubMed GONUTS page
  3. Stubbs, JL et al. (2008) The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos. Nat. Genet. 40 1454-60 PubMed GONUTS page
  4. 4.0 4.1 Yu, X et al. (2008) Foxj1 transcription factors are master regulators of the motile ciliogenic program. Nat. Genet. 40 1445-53 PubMed GONUTS page
  5. Lopes, SS et al. (2010) Notch signalling regulates left-right asymmetry through ciliary length control. Development 137 3625-32 PubMed GONUTS page
  6. Tay, SY et al. (2010) The iguana/DZIP1 protein is a novel component of the ciliogenic pathway essential for axonemal biogenesis. Dev. Dyn. 239 527-34 PubMed GONUTS page