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DANRE:PO5F1

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) pou5f1 (synonyms: gp-9, pou-2, pou2)
Protein Name(s) POU domain, class 5, transcription factor 1

POU domain protein 2

External Links
UniProt Q90270
EMBL D28548
X84224
PIR A49836
B49836
RefSeq NP_571187.1
UniGene Dr.258
ProteinModelPortal Q90270
SMR Q90270
STRING 7955.ENSDARP00000065816
Ensembl ENSDART00000065817
GeneID 30333
KEGG dre:30333
CTD 30333
ZFIN ZDB-GENE-980526-485
eggNOG NOG329627
GeneTree ENSGT00760000118935
HOGENOM HOG000063726
HOVERGEN HBG053782
InParanoid Q90270
KO K09369
OrthoDB EOG77DJ5X
TreeFam TF316413
Reactome REACT_238726
REACT_252692
NextBio 20806765
Proteomes UP000000437
Bgee Q90270
GO GO:0005634
GO:0046982
GO:0043565
GO:0003700
GO:0009653
GO:0007420
GO:0035284
GO:0009953
GO:0007398
GO:0009880
GO:0001706
GO:0055113
GO:0031101
GO:0030902
GO:0007498
GO:0016331
GO:0045893
GO:0044030
GO:0042663
GO:0006351
Gene3D 1.10.10.60
1.10.260.40
InterPro IPR017970
IPR001356
IPR009057
IPR010982
IPR013847
IPR000327
Pfam PF00046
PF00157
PRINTS PR00028
SMART SM00389
SM00352
SUPFAM SSF46689
SSF47413
PROSITE PS00027
PS50071
PS00035
PS00465
PS51179

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001706

endoderm formation

PMID:14711414[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020117-1

P

Seeded From UniProt

complete

GO:0001706

endoderm formation

PMID:14723850[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020426-1

P

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356
InterPro:IPR009057
InterPro:IPR010982
InterPro:IPR013847

F

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0371

F

Seeded From UniProt

complete

GO:0003682

chromatin binding

PMID:24643012[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000327

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

PMID:14723850[2]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-011026-1

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000327
InterPro:IPR017970

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007398

ectoderm development

PMID:11861475[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020426-1

P

Seeded From UniProt

complete

GO:0007398

ectoderm development

PMID:11861475[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020625-1

P

Seeded From UniProt

complete

GO:0007420

brain development

PMID:11861475[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020426-1

P

Seeded From UniProt

complete

GO:0007420

brain development

PMID:11861475[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020625-1

P

Seeded From UniProt

complete

GO:0007420

brain development

PMID:15593329[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-050317-6

P

Seeded From UniProt

complete

GO:0007498

mesoderm development

PMID:11861475[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020426-1

P

Seeded From UniProt

complete

GO:0007498

mesoderm development

PMID:11861475[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020625-1

P

Seeded From UniProt

complete

GO:0009653

anatomical structure morphogenesis

PMID:11861475[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020426-1

P

Seeded From UniProt

complete

GO:0009653

anatomical structure morphogenesis

PMID:11861475[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020625-1

P

Seeded From UniProt

complete

GO:0009880

embryonic pattern specification

PMID:11861475[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020426-1

P

Seeded From UniProt

complete

GO:0009880

embryonic pattern specification

PMID:11861475[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020625-1

P

Seeded From UniProt

complete

GO:0009880

embryonic pattern specification

PMID:15366005[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-100414-8

P

Seeded From UniProt

complete

GO:0009953

dorsal/ventral pattern formation

PMID:16775002[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070223-1

P

Seeded From UniProt

complete

GO:0010468

regulation of gene expression

PMID:24643012[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-110725-7

P

Seeded From UniProt

complete

GO:0016331

morphogenesis of embryonic epithelium

PMID:11861475[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020426-1

P

Seeded From UniProt

complete

GO:0016331

morphogenesis of embryonic epithelium

PMID:11861475[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020625-1

P

Seeded From UniProt

complete

GO:0030902

hindbrain development

PMID:11923201[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020117-1

P

Seeded From UniProt

complete

GO:0030902

hindbrain development

PMID:11923201[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-270

P

Seeded From UniProt

complete

GO:0031101

fin regeneration

PMID:20089153[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-081015-1

P

Seeded From UniProt

complete

GO:0035284

brain segmentation

PMID:11923201[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020117-1

P

Seeded From UniProt

complete

GO:0035284

brain segmentation

PMID:11923201[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-270

P

Seeded From UniProt

complete

GO:0042663

regulation of endodermal cell fate specification

PMID:23364327[10]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-010108-1
ZFIN:ZDB-GENE-011026-1

P

Seeded From UniProt

complete

GO:0042663

regulation of endodermal cell fate specification

PMID:23364327[10]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-011026-1

P

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

PMID:23950494[11]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

PMID:23950494[11]

IPI: Inferred from Physical Interaction

ZFIN:ZDB-GENE-010111-1

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

PMID:23950494[11]

IPI: Inferred from Physical Interaction

ZFIN:ZDB-GENE-010416-1

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

PMID:23950494[11]

IPI: Inferred from Physical Interaction

ZFIN:ZDB-GENE-030131-5486

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

PMID:23950494[11]

IPI: Inferred from Physical Interaction

ZFIN:ZDB-GENE-030909-1

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

PMID:23950494[11]

IPI: Inferred from Physical Interaction

ZFIN:ZDB-GENE-980526-102

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

PMID:23950494[11]

IPI: Inferred from Physical Interaction

ZFIN:ZDB-GENE-980526-333

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

PMID:23950494[11]

IPI: Inferred from Physical Interaction

ZFIN:ZDB-GENE-980526-485

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

PMID:23950494[11]

IPI: Inferred from Physical Interaction

ZFIN:ZDB-GENE-980605-4

F

Seeded From UniProt

complete

GO:0044030

regulation of DNA methylation

PMID:20850014[12]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-090916-1
ZFIN:ZDB-MRPHLNO-081015-1

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:14723850[2]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-011026-1

P

Seeded From UniProt

complete

GO:0046982

protein heterodimerization activity

PMID:23364327[10]

IPI: Inferred from Physical Interaction

ZFIN:ZDB-GENE-010108-1

F

Seeded From UniProt

complete

GO:0046982

protein heterodimerization activity

PMID:23364327[10]

IPI: Inferred from Physical Interaction

ZFIN:ZDB-GENE-011026-1

F

Seeded From UniProt

complete

GO:0055113

epiboly involved in gastrulation with mouth forming second

PMID:18215655[13]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-081023-1

P

Seeded From UniProt

complete

GO:0055113

epiboly involved in gastrulation with mouth forming second

PMID:18215655[13]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-081023-2

P

Seeded From UniProt

complete

GO:0055113

epiboly involved in gastrulation with mouth forming second

PMID:18215655[13]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-081023-3

P

Seeded From UniProt

complete

GO:0090504

epiboly

PMID:23484854[14]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-110725-7

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Lunde, K et al. (2004) Zebrafish pou5f1/pou2, homolog of mammalian Oct4, functions in the endoderm specification cascade. Curr. Biol. 14 48-55 PubMed GONUTS page
  2. 2.0 2.1 2.2 Reim, G et al. (2004) The POU domain protein spg (pou2/Oct4) is essential for endoderm formation in cooperation with the HMG domain protein casanova. Dev. Cell 6 91-101 PubMed GONUTS page
  3. 3.0 3.1 Kotkamp, K et al. (2014) Pou5f1/Oct4 promotes cell survival via direct activation of mych expression during zebrafish gastrulation. PLoS ONE 9 e92356 PubMed GONUTS page
  4. 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 Reim, G & Brand, M (2002) Spiel-ohne-grenzen/pou2 mediates regional competence to respond to Fgf8 during zebrafish early neural development. Development 129 917-33 PubMed GONUTS page
  5. Wiellette, E et al. (2004) Combined haploid and insertional mutation screen in the zebrafish. Genesis 40 231-40 PubMed GONUTS page
  6. Riley, BB et al. (2004) Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain. Dev. Dyn. 231 278-91 PubMed GONUTS page
  7. Reim, G & Brand, M (2006) Maternal control of vertebrate dorsoventral axis formation and epiboly by the POU domain protein Spg/Pou2/Oct4. Development 133 2757-70 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Hauptmann, G et al. (2002) spiel ohne grenzen/pou2 is required for zebrafish hindbrain segmentation. Development 129 1645-55 PubMed GONUTS page
  9. Christen, B et al. (2010) Regeneration and reprogramming compared. BMC Biol. 8 5 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 Zhao, J et al. (2013) The transcription factor Vox represses endoderm development by interacting with Casanova and Pou2. Development 140 1090-9 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 11.4 11.5 11.6 11.7 11.8 Leichsenring, M et al. (2013) Pou5f1 transcription factor controls zygotic gene activation in vertebrates. Science 341 1005-9 PubMed GONUTS page
  12. Rai, K et al. (2010) DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC. Cell 142 930-42 PubMed GONUTS page
  13. 13.0 13.1 13.2 Lachnit, M et al. (2008) Alterations of the cytoskeleton in all three embryonic lineages contribute to the epiboly defect of Pou5f1/Oct4 deficient MZspg zebrafish embryos. Dev. Biol. 315 1-17 PubMed GONUTS page
  14. Song, S et al. (2013) Pou5f1-dependent EGF expression controls E-cadherin endocytosis, cell adhesion, and zebrafish epiboly movements. Dev. Cell 24 486-501 PubMed GONUTS page