DANRE:PO5F1

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	pou5f1 (synonyms: gp-9, pou-2, pou2)
Protein Name(s)	POU domain, class 5, transcription factor 1 POU domain protein 2
External Links
UniProt	Q90270
EMBL	D28548 X84224
PIR	A49836 B49836
RefSeq	NP_571187.1
UniGene	Dr.258
ProteinModelPortal	Q90270
SMR	Q90270
STRING	7955.ENSDARP00000065816
Ensembl	ENSDART00000065817
GeneID	30333
KEGG	dre:30333
CTD	30333
ZFIN	ZDB-GENE-980526-485
eggNOG	NOG329627
GeneTree	ENSGT00760000118935
HOGENOM	HOG000063726
HOVERGEN	HBG053782
InParanoid	Q90270
KO	K09369
OrthoDB	EOG77DJ5X
TreeFam	TF316413
Reactome	REACT_238726 REACT_252692
NextBio	20806765
Proteomes	UP000000437
Bgee	Q90270
GO	GO:0005634 GO:0046982 GO:0043565 GO:0003700 GO:0009653 GO:0007420 GO:0035284 GO:0009953 GO:0007398 GO:0009880 GO:0001706 GO:0055113 GO:0031101 GO:0030902 GO:0007498 GO:0016331 GO:0045893 GO:0044030 GO:0042663 GO:0006351
Gene3D	1.10.10.60 1.10.260.40
InterPro	IPR017970 IPR001356 IPR009057 IPR010982 IPR013847 IPR000327
Pfam	PF00046 PF00157
PRINTS	PR00028
SMART	SM00389 SM00352
SUPFAM	SSF46689 SSF47413
PROSITE	PS00027 PS50071 PS00035 PS00465 PS51179

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0090504	epiboly	PMID:23484854^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-110725-7	P	Seeded From UniProt	complete
involved_in	GO:0055113	epiboly involved in gastrulation with mouth forming second	PMID:18215655^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-081023-3	P	Seeded From UniProt	complete
involved_in	GO:0055113	epiboly involved in gastrulation with mouth forming second	PMID:18215655^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-081023-2	P	Seeded From UniProt	complete
involved_in	GO:0055113	epiboly involved in gastrulation with mouth forming second	PMID:18215655^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-081023-1	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:23364327^[3]	ECO:0000353	physical interaction evidence used in manual assertion	ZFIN:ZDB-GENE-011026-1	F	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:23364327^[3]	ECO:0000353	physical interaction evidence used in manual assertion	ZFIN:ZDB-GENE-010108-1	F	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:14723850^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-011026-1	P	Seeded From UniProt	complete
involved_in	GO:0044030	regulation of DNA methylation	PMID:20850014^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-090916-1 ZFIN:ZDB-MRPHLNO-081015-1	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:23950494^[6]	ECO:0000353	physical interaction evidence used in manual assertion	ZFIN:ZDB-GENE-980605-4	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:23950494^[6]	ECO:0000353	physical interaction evidence used in manual assertion	ZFIN:ZDB-GENE-980526-485	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:23950494^[6]	ECO:0000353	physical interaction evidence used in manual assertion	ZFIN:ZDB-GENE-980526-333	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:23950494^[6]	ECO:0000353	physical interaction evidence used in manual assertion	ZFIN:ZDB-GENE-980526-102	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:23950494^[6]	ECO:0000353	physical interaction evidence used in manual assertion	ZFIN:ZDB-GENE-030909-1	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:23950494^[6]	ECO:0000353	physical interaction evidence used in manual assertion	ZFIN:ZDB-GENE-030131-5486	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:23950494^[6]	ECO:0000353	physical interaction evidence used in manual assertion	ZFIN:ZDB-GENE-010416-1	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:23950494^[6]	ECO:0000353	physical interaction evidence used in manual assertion	ZFIN:ZDB-GENE-010111-1	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:23950494^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042663	regulation of endodermal cell fate specification	PMID:23364327^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-011026-1	P	Seeded From UniProt	complete
involved_in	GO:0042663	regulation of endodermal cell fate specification	PMID:23364327^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-010108-1 ZFIN:ZDB-GENE-011026-1	P	Seeded From UniProt	complete
involved_in	GO:0035284	brain segmentation	PMID:11923201^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-270	P	Seeded From UniProt	complete
involved_in	GO:0035284	brain segmentation	PMID:11923201^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-020117-1	P	Seeded From UniProt	complete
involved_in	GO:0031101	fin regeneration	PMID:20089153^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-081015-1	P	Seeded From UniProt	complete
involved_in	GO:0030917	midbrain-hindbrain boundary development	PMID:9007238^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-270	P	Seeded From UniProt	complete
involved_in	GO:0030902	hindbrain development	PMID:11923201^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-270	P	Seeded From UniProt	complete
involved_in	GO:0030902	hindbrain development	PMID:11923201^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-020117-1	P	Seeded From UniProt	complete
involved_in	GO:0016331	morphogenesis of embryonic epithelium	PMID:11861475^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-020625-1	P	Seeded From UniProt	complete
involved_in	GO:0016331	morphogenesis of embryonic epithelium	PMID:11861475^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-020426-1	P	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:24643012^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-110725-7	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:16775002^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070223-1	P	Seeded From UniProt	complete
involved_in	GO:0009880	embryonic pattern specification	PMID:15366005^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-100414-8	P	Seeded From UniProt	complete
involved_in	GO:0009880	embryonic pattern specification	PMID:11861475^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-020625-1	P	Seeded From UniProt	complete
involved_in	GO:0009880	embryonic pattern specification	PMID:11861475^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-020426-1	P	Seeded From UniProt	complete
involved_in	GO:0009653	anatomical structure morphogenesis	PMID:11861475^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-020625-1	P	Seeded From UniProt	complete
involved_in	GO:0009653	anatomical structure morphogenesis	PMID:11861475^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-020426-1	P	Seeded From UniProt	complete
involved_in	GO:0007498	mesoderm development	PMID:11861475^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-020625-1	P	Seeded From UniProt	complete
involved_in	GO:0007498	mesoderm development	PMID:11861475^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-020426-1	P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:15593329^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-050317-6	P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:11861475^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-020625-1	P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:11861475^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-020426-1	P	Seeded From UniProt	complete
involved_in	GO:0007398	ectoderm development	PMID:11861475^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-020625-1	P	Seeded From UniProt	complete
involved_in	GO:0007398	ectoderm development	PMID:11861475^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-020426-1	P	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:14723850^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-011026-1	F	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:24643012^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001706	endoderm formation	PMID:14723850^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-020426-1	P	Seeded From UniProt	complete
involved_in	GO:0001706	endoderm formation	PMID:14711414^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-020117-1	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057 InterPro:IPR010982 InterPro:IPR013847	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000327	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000327 InterPro:IPR017970	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238 UniProtKB-KW:KW-0371	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Song, S et al. (2013) Pou5f1-dependent EGF expression controls E-cadherin endocytosis, cell adhesion, and zebrafish epiboly movements. Dev. Cell 24 486-501 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Lachnit, M et al. (2008) Alterations of the cytoskeleton in all three embryonic lineages contribute to the epiboly defect of Pou5f1/Oct4 deficient MZspg zebrafish embryos. Dev. Biol. 315 1-17 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Zhao, J et al. (2013) The transcription factor Vox represses endoderm development by interacting with Casanova and Pou2. Development 140 1090-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Reim, G et al. (2004) The POU domain protein spg (pou2/Oct4) is essential for endoderm formation in cooperation with the HMG domain protein casanova. Dev. Cell 6 91-101 PubMed GONUTS page
↑ Rai, K et al. (2010) DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC. Cell 142 930-42 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Leichsenring, M et al. (2013) Pou5f1 transcription factor controls zygotic gene activation in vertebrates. Science 341 1005-9 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Hauptmann, G et al. (2002) spiel ohne grenzen/pou2 is required for zebrafish hindbrain segmentation. Development 129 1645-55 PubMed GONUTS page
↑ Christen, B et al. (2010) Regeneration and reprogramming compared. BMC Biol. 8 5 PubMed GONUTS page
↑ Schier, AF et al. (1996) Mutations affecting the development of the embryonic zebrafish brain. Development 123 165-78 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 Reim, G & Brand, M (2002) Spiel-ohne-grenzen/pou2 mediates regional competence to respond to Fgf8 during zebrafish early neural development. Development 129 917-33 PubMed GONUTS page
↑ ^11.0 ^11.1 Kotkamp, K et al. (2014) Pou5f1/Oct4 promotes cell survival via direct activation of mych expression during zebrafish gastrulation. PLoS ONE 9 e92356 PubMed GONUTS page
↑ Reim, G & Brand, M (2006) Maternal control of vertebrate dorsoventral axis formation and epiboly by the POU domain protein Spg/Pou2/Oct4. Development 133 2757-70 PubMed GONUTS page
↑ Riley, BB et al. (2004) Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain. Dev. Dyn. 231 278-91 PubMed GONUTS page
↑ Wiellette, E et al. (2004) Combined haploid and insertional mutation screen in the zebrafish. Genesis 40 231-40 PubMed GONUTS page
↑ Lunde, K et al. (2004) Zebrafish pou5f1/pou2, homolog of mammalian Oct4, functions in the endoderm specification cascade. Curr. Biol. 14 48-55 PubMed GONUTS page

[PMID:23484854-1] Song, S et al. (2013) Pou5f1-dependent EGF expression controls E-cadherin endocytosis, cell adhesion, and zebrafish epiboly movements. Dev. Cell 24 486-501 PubMed GONUTS page

[PMID:18215655-2] 2.0 ^2.1 ^2.2 Lachnit, M et al. (2008) Alterations of the cytoskeleton in all three embryonic lineages contribute to the epiboly defect of Pou5f1/Oct4 deficient MZspg zebrafish embryos. Dev. Biol. 315 1-17 PubMed GONUTS page

[PMID:23364327-3] 3.0 ^3.1 ^3.2 ^3.3 Zhao, J et al. (2013) The transcription factor Vox represses endoderm development by interacting with Casanova and Pou2. Development 140 1090-9 PubMed GONUTS page

[PMID:14723850-4] 4.0 ^4.1 ^4.2 Reim, G et al. (2004) The POU domain protein spg (pou2/Oct4) is essential for endoderm formation in cooperation with the HMG domain protein casanova. Dev. Cell 6 91-101 PubMed GONUTS page

[PMID:20850014-5] Rai, K et al. (2010) DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC. Cell 142 930-42 PubMed GONUTS page

[PMID:23950494-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Leichsenring, M et al. (2013) Pou5f1 transcription factor controls zygotic gene activation in vertebrates. Science 341 1005-9 PubMed GONUTS page

[PMID:11923201-7] 7.0 ^7.1 ^7.2 ^7.3 Hauptmann, G et al. (2002) spiel ohne grenzen/pou2 is required for zebrafish hindbrain segmentation. Development 129 1645-55 PubMed GONUTS page

[PMID:20089153-8] Christen, B et al. (2010) Regeneration and reprogramming compared. BMC Biol. 8 5 PubMed GONUTS page

[PMID:9007238-9] Schier, AF et al. (1996) Mutations affecting the development of the embryonic zebrafish brain. Development 123 165-78 PubMed GONUTS page

[PMID:11861475-10] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 Reim, G & Brand, M (2002) Spiel-ohne-grenzen/pou2 mediates regional competence to respond to Fgf8 during zebrafish early neural development. Development 129 917-33 PubMed GONUTS page

[PMID:24643012-11] 11.0 ^11.1 Kotkamp, K et al. (2014) Pou5f1/Oct4 promotes cell survival via direct activation of mych expression during zebrafish gastrulation. PLoS ONE 9 e92356 PubMed GONUTS page

[PMID:16775002-12] Reim, G & Brand, M (2006) Maternal control of vertebrate dorsoventral axis formation and epiboly by the POU domain protein Spg/Pou2/Oct4. Development 133 2757-70 PubMed GONUTS page

[PMID:15366005-13] Riley, BB et al. (2004) Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain. Dev. Dyn. 231 278-91 PubMed GONUTS page

[PMID:15593329-14] Wiellette, E et al. (2004) Combined haploid and insertional mutation screen in the zebrafish. Genesis 40 231-40 PubMed GONUTS page

[PMID:14711414-15] Lunde, K et al. (2004) Zebrafish pou5f1/pou2, homolog of mammalian Oct4, functions in the endoderm specification cascade. Curr. Biol. 14 48-55 PubMed GONUTS page

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DANRE:PO5F1

Contents

Annotations

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References

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