DANRE:GLE1

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	gle1 (synonyms: gle1l)
Protein Name(s)	Nucleoporin GLE1 GLE1-like protein
External Links
UniProt	Q6DRB1
EMBL	AY648848 BC095550
UniGene	Dr.83661
SMR	Q6DRB1
STRING	7955.ENSDARP00000104523
PaxDb	Q6DRB1
ZFIN	ZDB-GENE-040831-4
eggNOG	KOG2412 ENOG410XT57
HOGENOM	HOG000246966
HOVERGEN	HBG081558
InParanoid	Q6DRB1
PRO	PR:Q6DRB1
Proteomes	UP000000437
GO	GO:0005737 GO:0044614 GO:0000822 GO:0005543 GO:0031369 GO:0048666 GO:0016973 GO:0006446 GO:0006449 GO:0014037 GO:0014010
InterPro	IPR012476
PANTHER	PTHR12960
Pfam	PF07817

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000822	inositol hexakisphosphate binding	GO_REF:0000033	IBA: Inferred from Biological aspect of Ancestor	PANTHER:PTN000311158	F	Seeded From UniProt
	GO:0005543	phospholipid binding	GO_REF:0000033	IBA: Inferred from Biological aspect of Ancestor	PANTHER:PTN000311158	F	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000037	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0539	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000039	IEA: Inferred from Electronic Annotation	UniProtKB-SubCell:SL-0191	C	Seeded From UniProt
	GO:0005643	nuclear pore	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012476	C	Seeded From UniProt
	GO:0005643	nuclear pore	GO_REF:0000037	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0906	C	Seeded From UniProt
	GO:0005643	nuclear pore	GO_REF:0000039	IEA: Inferred from Electronic Annotation	UniProtKB-SubCell:SL-0185	C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000033	IBA: Inferred from Biological aspect of Ancestor	PANTHER:PTN000311158	C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000037	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0963	C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000039	IEA: Inferred from Electronic Annotation	UniProtKB-SubCell:SL-0086	C	Seeded From UniProt
	GO:0006446	regulation of translational initiation	GO_REF:0000033	IBA: Inferred from Biological aspect of Ancestor	PANTHER:PTN000311158	P	Seeded From UniProt
	GO:0006449	regulation of translational termination	GO_REF:0000033	IBA: Inferred from Biological aspect of Ancestor	PANTHER:PTN000311158	P	Seeded From UniProt
	GO:0006810	transport	GO_REF:0000037	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0811	P	Seeded From UniProt
	GO:0006810	transport	GO_REF:0000037	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0813	P	Seeded From UniProt
	GO:0014010	Schwann cell proliferation	PMID:26921650	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-160602-2	P	Seeded From UniProt
	GO:0014037	Schwann cell differentiation	PMID:26921650	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-160602-2	P	Seeded From UniProt
	GO:0015031	protein transport	GO_REF:0000037	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0653	P	Seeded From UniProt
	GO:0016973	poly(A)+ mRNA export from nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012476	P	Seeded From UniProt
	GO:0016973	poly(A)+ mRNA export from nucleus	PMID:26921650	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-160602-2	P	Seeded From UniProt
	GO:0031369	translation initiation factor binding	GO_REF:0000033	IBA: Inferred from Biological aspect of Ancestor	PANTHER:PTN000311158	F	Seeded From UniProt
	GO:0044614	nuclear pore cytoplasmic filaments	GO_REF:0000033	IBA: Inferred from Biological aspect of Ancestor	PANTHER:PTN000311158	C	Seeded From UniProt
	GO:0048666	neuron development	PMID:25343993	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-120406-2,ZFIN:ZDB-MRPHLNO-120406-3	P	Seeded From UniProt
	GO:0051028	mRNA transport	GO_REF:0000037	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0509	P	Seeded From UniProt
	GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry	PMID:28035044	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-050830-1,ZFIN:ZDB-MRPHLNO-120406-2,ZFIN:ZDB-MRPHLNO-120406-3	P	Seeded From UniProt
	GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry	PMID:28035044	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-120406-2,ZFIN:ZDB-MRPHLNO-120406-3	P	Seeded From UniProt
	GO:0060296	regulation of cilium beat frequency involved in ciliary motility	PMID:28035044	IMP: Inferred from Mutant Phenotype		P	Fig. 5 Parts A-B shows that a depletion of Gle1 reduces ciliary beating and alters left–right asymmetry in the organism Danio rerio (Zebrafish). An antisense morpholino was used in creating a mutant phenotype with a knockdown Zebrafish Gle1. Both the experiment and Uniprot refer to the gene as Gle1. A new GO term was requested for "positive regulation of cilium beat frequency involved in ciliary motility" at https://github.com/geneontology/go-ontology/issues/13375	complete CACAO 12649
	GO:0014044	Schwann cell development	PMID:26921650	IMP: Inferred from Mutant Phenotype		P	Fig. 4 Parts A, C, E and G shows defective Schwann cell development in mutants for Gle1 in comparison to Fig. 4 Parts B, D, F and H which consisted of wild type siblings. Both UniProt and the experiment refers to the gene as Gle1, and the organism is Danio rerio (Zebrafish).	complete CACAO 12700
	GO:1905046	positive regulation of Schwann cell proliferation involved in axon regeneration	PMID:26921650	IMP: Inferred from Mutant Phenotype		P	Fig. 6 Parts A-D shows the requirement of Gle1 for the formation of myelinating Schwann cells with comparison of mutant and wild type axons. Fig. 5 Parts A-B shows the requirement of Gle1 for proper proliferation of Schwann cell precursors, as the mutants showed reduced proliferation. Both the experiment and UniProt refer to the gene as Gle1. The organism is Danio rerio (Zebrafish).	complete CACAO 12702
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References

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