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DANRE:GLE1
Contents
| Species (Taxon ID) | Danio rerio (Zebrafish) (Brachydanio rerio). (7955) | |
| Gene Name(s) | gle1 (synonyms: gle1l) | |
| Protein Name(s) | Nucleoporin GLE1
GLE1-like protein | |
| External Links | ||
| UniProt | Q6DRB1 | |
| EMBL | AY648848 BC095550 | |
| UniGene | Dr.83661 | |
| SMR | Q6DRB1 | |
| STRING | 7955.ENSDARP00000104523 | |
| PaxDb | Q6DRB1 | |
| ZFIN | ZDB-GENE-040831-4 | |
| eggNOG | KOG2412 ENOG410XT57 | |
| HOGENOM | HOG000246966 | |
| HOVERGEN | HBG081558 | |
| InParanoid | Q6DRB1 | |
| PRO | PR:Q6DRB1 | |
| Proteomes | UP000000437 | |
| GO | GO:0005737 GO:0044614 GO:0000822 GO:0005543 GO:0031369 GO:0048666 GO:0016973 GO:0006446 GO:0006449 GO:0014037 GO:0014010 | |
| InterPro | IPR012476 | |
| PANTHER | PTHR12960 | |
| Pfam | PF07817 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0060287 |
epithelial cilium movement involved in determination of left/right asymmetry |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-050830-1 |
P |
Seeded From UniProt |
complete | ||
| GO:0060296 |
regulation of cilium beat frequency involved in ciliary motility |
ECO:0000315 |
P |
Fig. 5 Parts A-B shows that a depletion of Gle1 reduces ciliary beating and alters left–right asymmetry in the organism Danio rerio (Zebrafish). An antisense morpholino was used in creating a mutant phenotype with a knockdown Zebrafish Gle1. Both the experiment and Uniprot refer to the gene as Gle1. A new GO term was requested for "positive regulation of cilium beat frequency involved in ciliary motility" at https://github.com/geneontology/go-ontology/issues/13375 |
complete | |||||
|
involved_in |
GO:0060287 |
epithelial cilium movement involved in determination of left/right asymmetry |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-120406-2 |
P |
Seeded From UniProt |
complete | ||
| GO:0014044 |
Schwann cell development |
ECO:0000315 |
P |
Fig. 4 Parts A, C, E and G shows defective Schwann cell development in mutants for Gle1 in comparison to Fig. 4 Parts B, D, F and H which consisted of wild type siblings. Both UniProt and the experiment refers to the gene as Gle1, and the organism is Danio rerio (Zebrafish). |
complete | |||||
|
involved_in |
GO:0048666 |
neuron development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-120406-2 |
P |
Seeded From UniProt |
complete | ||
| GO:1905046 |
positive regulation of Schwann cell proliferation involved in axon regeneration |
ECO:0000315 |
P |
Fig. 6 Parts A-D shows the requirement of Gle1 for the formation of myelinating Schwann cells with comparison of mutant and wild type axons. Fig. 5 Parts A-B shows the requirement of Gle1 for proper proliferation of Schwann cell precursors, as the mutants showed reduced proliferation. Both the experiment and UniProt refer to the gene as Gle1. The organism is Danio rerio (Zebrafish). |
complete | |||||
|
involved_in |
GO:0016973 |
poly(A)+ mRNA export from nucleus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-160602-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014037 |
Schwann cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-160602-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014010 |
Schwann cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-160602-2 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0044614 |
nuclear pore cytoplasmic filaments |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000311158 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031369 |
translation initiation factor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000311158 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006449 |
regulation of translational termination |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000311158 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006446 |
regulation of translational initiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000311158 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006406 |
mRNA export from nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000311158 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000311158 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005543 |
phospholipid binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000311158 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000822 |
inositol hexakisphosphate binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000311158 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005643 |
nuclear pore |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016973 |
poly(A)+ mRNA export from nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005643 |
nuclear pore |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051028 |
mRNA transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015031 |
protein transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Jao, LE et al. (2017) A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. Mol. Biol. Cell 28 120-127 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Seytanoglu, A et al. (2016) Deficiency in the mRNA export mediator Gle1 impairs Schwann cell development in the zebrafish embryo. Neuroscience 322 287-97 PubMed GONUTS page
- ↑ Kaneb, HM et al. (2015) Deleterious mutations in the essential mRNA metabolism factor, hGle1, in amyotrophic lateral sclerosis. Hum. Mol. Genet. 24 1363-73 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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