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DANRE:GLE1

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) gle1 (synonyms: gle1l)
Protein Name(s) Nucleoporin GLE1

GLE1-like protein

External Links
UniProt Q6DRB1
EMBL AY648848
BC095550
UniGene Dr.83661
SMR Q6DRB1
STRING 7955.ENSDARP00000104523
PaxDb Q6DRB1
ZFIN ZDB-GENE-040831-4
eggNOG KOG2412
ENOG410XT57
HOGENOM HOG000246966
HOVERGEN HBG081558
InParanoid Q6DRB1
PRO PR:Q6DRB1
Proteomes UP000000437
GO GO:0005737
GO:0044614
GO:0000822
GO:0005543
GO:0031369
GO:0048666
GO:0016973
GO:0006446
GO:0006449
GO:0014037
GO:0014010
InterPro IPR012476
PANTHER PTHR12960
Pfam PF07817

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000822

inositol hexakisphosphate binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000311158

F

Seeded From UniProt

GO:0005543

phospholipid binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000311158

F

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

GO:0005643

nuclear pore

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012476

C

Seeded From UniProt

GO:0005643

nuclear pore

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0906

C

Seeded From UniProt

GO:0005643

nuclear pore

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0185

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000311158

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

GO:0006446

regulation of translational initiation

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000311158

P

Seeded From UniProt

GO:0006449

regulation of translational termination

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000311158

P

Seeded From UniProt

GO:0006810

transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0811

P

Seeded From UniProt

GO:0006810

transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

Seeded From UniProt

GO:0014010

Schwann cell proliferation

PMID:26921650[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-160602-2

P

Seeded From UniProt

GO:0014037

Schwann cell differentiation

PMID:26921650[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-160602-2

P

Seeded From UniProt

GO:0015031

protein transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0653

P

Seeded From UniProt

GO:0016973

poly(A)+ mRNA export from nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012476

P

Seeded From UniProt

GO:0016973

poly(A)+ mRNA export from nucleus

PMID:26921650[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-160602-2

P

Seeded From UniProt

GO:0031369

translation initiation factor binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000311158

F

Seeded From UniProt

GO:0044614

nuclear pore cytoplasmic filaments

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000311158

C

Seeded From UniProt

GO:0048666

neuron development

PMID:25343993[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-120406-2,ZFIN:ZDB-MRPHLNO-120406-3

P

Seeded From UniProt

GO:0051028

mRNA transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0509

P

Seeded From UniProt

GO:0060287

epithelial cilium movement involved in determination of left/right asymmetry

PMID:28035044[3]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-050830-1,ZFIN:ZDB-MRPHLNO-120406-2,ZFIN:ZDB-MRPHLNO-120406-3

P

Seeded From UniProt

GO:0060287

epithelial cilium movement involved in determination of left/right asymmetry

PMID:28035044[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-120406-2,ZFIN:ZDB-MRPHLNO-120406-3

P

Seeded From UniProt

GO:0060296

regulation of cilium beat frequency involved in ciliary motility

PMID:28035044[3]

IMP: Inferred from Mutant Phenotype

P

Fig. 5 Parts A-B shows that a depletion of Gle1 reduces ciliary beating and alters left–right asymmetry in the organism Danio rerio (Zebrafish). An antisense morpholino was used in creating a mutant phenotype with a knockdown Zebrafish Gle1. Both the experiment and Uniprot refer to the gene as Gle1. A new GO term was requested for "positive regulation of cilium beat frequency involved in ciliary motility" at https://github.com/geneontology/go-ontology/issues/13375

complete
CACAO 12649

GO:0014044

Schwann cell development

PMID:26921650[1]

IMP: Inferred from Mutant Phenotype

P

Fig. 4 Parts A, C, E and G shows defective Schwann cell development in mutants for Gle1 in comparison to Fig. 4 Parts B, D, F and H which consisted of wild type siblings. Both UniProt and the experiment refers to the gene as Gle1, and the organism is Danio rerio (Zebrafish).

complete
CACAO 12700

GO:1905046

positive regulation of Schwann cell proliferation involved in axon regeneration

PMID:26921650[1]

IMP: Inferred from Mutant Phenotype

P

Fig. 6 Parts A-D shows the requirement of Gle1 for the formation of myelinating Schwann cells with comparison of mutant and wild type axons. Fig. 5 Parts A-B shows the requirement of Gle1 for proper proliferation of Schwann cell precursors, as the mutants showed reduced proliferation. Both the experiment and UniProt refer to the gene as Gle1. The organism is Danio rerio (Zebrafish).

complete
CACAO 12702

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Seytanoglu, A et al. (2016) Deficiency in the mRNA export mediator Gle1 impairs Schwann cell development in the zebrafish embryo. Neuroscience 322 287-97 PubMed GONUTS page
  2. Kaneb, HM et al. (2015) Deleterious mutations in the essential mRNA metabolism factor, hGle1, in amyotrophic lateral sclerosis. Hum. Mol. Genet. 24 1363-73 PubMed GONUTS page
  3. 3.0 3.1 3.2 Jao, LE et al. (2017) A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. Mol. Biol. Cell 28 120-127 PubMed GONUTS page