DANRE:E7FB98

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	ubiad1 (synonyms: bar, reh)
Protein Name(s)	UbiA prenyltransferase domain-containing protein 1 Protein barolo Protein reddish
External Links
UniProt	E7FB98
EMBL	CABZ01068151
RefSeq	NP_001186655.1
UniGene	Dr.78772
Ensembl	ENSDART00000015554
GeneID	558410
KEGG	dre:558410
CTD	29914
ZFIN	ZDB-GENE-030131-3205
GeneTree	ENSGT00390000012439
InParanoid	E7FB98
OMA	HCAGNVV
OrthoDB	EOG7XH6Q2
PhylomeDB	E7FB98
TreeFam	TF323238
UniPathway	UPA00079 UPA00232
NextBio	20882456
Proteomes	UP000000437
Bgee	E7FB98
GO	GO:0005789 GO:0005794 GO:0030173 GO:0005739 GO:0016209 GO:0004517 GO:0004659 GO:0072358 GO:0071498 GO:0001885 GO:0009234 GO:0055114 GO:0006744 GO:0032194 GO:0042371
InterPro	IPR000537 IPR026046
Pfam	PF01040
PIRSF	PIRSF005355

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0030656	regulation of vitamin metabolic process	PMID:23533172^[1]	ECO:0000315			P	Figure 5: UBIAD1 regulates menaquinone/vitamin K2 metabolism to maintain cranial vasculature.	complete CACAO 7318
	GO:0006916	anti-apoptosis	PMID:23533172^[1]	ECO:0000315			P	Figure 3: Vascular integrity and endothelial survival are compromised in reh mutants due to increased apoptosis.	complete CACAO 7319
involved_in	GO:0072358	cardiovascular system development	PMID:23533172^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072358	cardiovascular system development	PMID:23374346^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042371	vitamin K biosynthetic process	PMID:23533172^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030173	integral component of Golgi membrane	PMID:23374346^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0016209	antioxidant activity	PMID:23374346^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0009234	menaquinone biosynthetic process	PMID:23533172^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006744	ubiquinone biosynthetic process	PMID:23374346^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004659	prenyltransferase activity	PMID:23374346^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001885	endothelial cell development	PMID:23533172^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072358	cardiovascular system development	PMID:23374346^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-130327-5	P	Seeded From UniProt	complete
involved_in	GO:0072358	cardiovascular system development	PMID:23374346^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-130327-5	P	Seeded From UniProt	complete
involved_in	GO:0072358	cardiovascular system development	PMID:23374346^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-130327-4	P	Seeded From UniProt	complete
involved_in	GO:0071498	cellular response to fluid shear stress	PMID:23374346^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-130327-5 ZFIN:ZDB-MRPHLNO-100610-8	P	Seeded From UniProt	complete
involved_in	GO:0071498	cellular response to fluid shear stress	PMID:23374346^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-130327-5 ZFIN:ZDB-MRPHLNO-060317-4	P	Seeded From UniProt	complete
involved_in	GO:0032194	ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate	PMID:24177291^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-130327-4	P	Seeded From UniProt	complete
involved_in	GO:0006744	ubiquinone biosynthetic process	PMID:23374346^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-130327-5	P	Seeded From UniProt	complete
involved_in	GO:0006744	ubiquinone biosynthetic process	PMID:23374346^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-130327-4	P	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:23374346^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004659	prenyltransferase activity	PMID:24177291^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-130327-4	F	Seeded From UniProt	complete
enables	GO:0004659	prenyltransferase activity	PMID:23374346^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	PMID:23374346^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-130327-5 ZFIN:ZDB-MRPHLNO-100503-13	F	Seeded From UniProt	complete
involved_in	GO:0042371	vitamin K biosynthetic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000358054 UniProtKB:Q9Y5Z9	P	Seeded From UniProt	complete
involved_in	GO:0032194	ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000358054 ZFIN:ZDB-GENE-030131-3205	P	Seeded From UniProt	complete
part_of	GO:0030173	integral component of Golgi membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001016945 UniProtKB:Q9Y5Z9 ZFIN:ZDB-GENE-030131-3205	C	Seeded From UniProt	complete
involved_in	GO:0009234	menaquinone biosynthetic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11880 FB:FBgn0028375 PANTHER:PTN000358054 UniProtKB:Q9Y5Z9	P	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028375 PANTHER:PTN001016945 UniProtKB:Q9Y5Z9	C	Seeded From UniProt	complete
enables	GO:0004659	prenyltransferase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000358054 UniProtKB:Q9Y5Z9 ZFIN:ZDB-GENE-030131-3205	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004517	P	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016209	P	Seeded From UniProt	complete
enables	GO:0004659	prenyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026046	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000537	C	Seeded From UniProt	complete
enables	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000537	F	Seeded From UniProt	complete
involved_in	GO:0009234	menaquinone biosynthetic process	GO_REF:0000037 GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0474 UniPathway:UPA00079	P	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C	Seeded From UniProt	complete
involved_in	GO:0006744	ubiquinone biosynthetic process	GO_REF:0000037 GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0831 UniPathway:UPA00232	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C	Seeded From UniProt	complete
enables	GO:0004659	prenyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0637	F	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Hegarty, JM et al. (2013) UBIAD1-mediated vitamin K2 synthesis is required for vascular endothelial cell survival and development. Development 140 1713-9 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 Mugoni, V et al. (2013) Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis. Cell 152 504-18 PubMed GONUTS page
↑ ^3.0 ^3.1 Mugoni, V et al. (2013) 13C-isotope-based protocol for prenyl lipid metabolic analysis in zebrafish embryos. Nat Protoc 8 2337-47 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23533172-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Hegarty, JM et al. (2013) UBIAD1-mediated vitamin K2 synthesis is required for vascular endothelial cell survival and development. Development 140 1713-9 PubMed GONUTS page

[PMID:23374346-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 Mugoni, V et al. (2013) Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis. Cell 152 504-18 PubMed GONUTS page

[PMID:24177291-3] 3.0 ^3.1 Mugoni, V et al. (2013) 13C-isotope-based protocol for prenyl lipid metabolic analysis in zebrafish embryos. Nat Protoc 8 2337-47 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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DANRE:E7FB98

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