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DANRE:E7FB98

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) ubiad1 (synonyms: bar, reh)
Protein Name(s) UbiA prenyltransferase domain-containing protein 1

Protein barolo Protein reddish

External Links
UniProt E7FB98
EMBL CABZ01068151
RefSeq NP_001186655.1
UniGene Dr.78772
Ensembl ENSDART00000015554
GeneID 558410
KEGG dre:558410
CTD 29914
ZFIN ZDB-GENE-030131-3205
GeneTree ENSGT00390000012439
InParanoid E7FB98
OMA HCAGNVV
OrthoDB EOG7XH6Q2
PhylomeDB E7FB98
TreeFam TF323238
UniPathway UPA00079
UPA00232
NextBio 20882456
Proteomes UP000000437
Bgee E7FB98
GO GO:0005789
GO:0005794
GO:0030173
GO:0005739
GO:0016209
GO:0004517
GO:0004659
GO:0072358
GO:0071498
GO:0001885
GO:0009234
GO:0055114
GO:0006744
GO:0032194
GO:0042371
InterPro IPR000537
IPR026046
Pfam PF01040
PIRSF PIRSF005355

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0030656

regulation of vitamin metabolic process

PMID:23533172[1]

IMP: Inferred from Mutant Phenotype

P

Figure 5: UBIAD1 regulates menaquinone/vitamin K2 metabolism to maintain cranial vasculature.

complete
CACAO 7318

GO:0006916

anti-apoptosis

PMID:23533172[1]

IMP: Inferred from Mutant Phenotype

P

Figure 3: Vascular integrity and endothelial survival are compromised in reh mutants due to increased apoptosis.

complete
CACAO 7319

GO:0000139

Golgi membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0134

C

Seeded From UniProt

complete

GO:0001885

endothelial cell development

PMID:23533172[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0004517

nitric-oxide synthase activity

PMID:23374346[2]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-130327-5
ZFIN:ZDB-MRPHLNO-100503-13

F

Seeded From UniProt

complete

GO:0004659

prenyltransferase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000537

F

Seeded From UniProt

complete

GO:0004659

prenyltransferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0637

F

Seeded From UniProt

complete

GO:0004659

prenyltransferase activity

PMID:23374346[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004659

prenyltransferase activity

PMID:23374346[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004659

prenyltransferase activity

PMID:24177291[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-130327-4

F

Seeded From UniProt

complete

GO:0005739

mitochondrion

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

GO:0005739

mitochondrion

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

GO:0005783

endoplasmic reticulum

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

GO:0005794

Golgi apparatus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0333

C

Seeded From UniProt

complete

GO:0005794

Golgi apparatus

PMID:23374346[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006744

ubiquinone biosynthetic process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0831

P

Seeded From UniProt

complete

GO:0006744

ubiquinone biosynthetic process

GO_REF:0000041

IEA: Inferred from Electronic Annotation

UniPathway:UPA00232

P

Seeded From UniProt

complete

GO:0006744

ubiquinone biosynthetic process

PMID:23374346[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006744

ubiquinone biosynthetic process

PMID:23374346[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-130327-4

P

Seeded From UniProt

complete

GO:0006744

ubiquinone biosynthetic process

PMID:23374346[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-130327-5

P

Seeded From UniProt

complete

GO:0009234

menaquinone biosynthetic process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0474

P

Seeded From UniProt

complete

GO:0009234

menaquinone biosynthetic process

GO_REF:0000041

IEA: Inferred from Electronic Annotation

UniPathway:UPA00079

P

Seeded From UniProt

complete

GO:0009234

menaquinone biosynthetic process

PMID:23533172[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000537

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016209

antioxidant activity

PMID:23374346[2]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0030173

integral component of Golgi membrane

PMID:23374346[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0032194

ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate

PMID:24177291[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-130327-4

P

Seeded From UniProt

complete

GO:0042371

vitamin K biosynthetic process

PMID:23533172[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0055114

oxidation-reduction process

PMID:23374346[2]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-130327-5
ZFIN:ZDB-MRPHLNO-100503-13

P

Seeded From UniProt

complete

GO:0071498

cellular response to fluid shear stress

PMID:23374346[2]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-130327-5
ZFIN:ZDB-MRPHLNO-060317-4

P

Seeded From UniProt

complete

GO:0071498

cellular response to fluid shear stress

PMID:23374346[2]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-130327-5
ZFIN:ZDB-MRPHLNO-100610-8

P

Seeded From UniProt

complete

GO:0072358

cardiovascular system development

PMID:23374346[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0072358

cardiovascular system development

PMID:23374346[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-130327-4

P

Seeded From UniProt

complete

GO:0072358

cardiovascular system development

PMID:23374346[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-130327-5

P

Seeded From UniProt

complete

GO:0072358

cardiovascular system development

PMID:23374346[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-130327-5

P

Seeded From UniProt

complete

GO:0072358

cardiovascular system development

PMID:23533172[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Hegarty, JM et al. (2013) UBIAD1-mediated vitamin K2 synthesis is required for vascular endothelial cell survival and development. Development 140 1713-9 PubMed GONUTS page
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 Mugoni, V et al. (2013) Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis. Cell 152 504-18 PubMed GONUTS page
  3. 3.0 3.1 Mugoni, V et al. (2013) 13C-isotope-based protocol for prenyl lipid metabolic analysis in zebrafish embryos. Nat Protoc 8 2337-47 PubMed GONUTS page