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DANRE:C166A

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) alcama (synonyms: alcam, cd166)
Protein Name(s) CD166 antigen homolog A

Activated leukocyte cell adhesion molecule A DM-GRASP homolog Neurolin

External Links
UniProt Q90460
EMBL L25273
L25057
RefSeq NP_571075.1
UniGene Dr.20912
ProteinModelPortal Q90460
PRIDE Q90460
GeneID 30194
KEGG dre:30194
CTD 30194
ZFIN ZDB-GENE-990415-30
eggNOG NOG148902
HOGENOM HOG000070101
HOVERGEN HBG050847
InParanoid Q90460
KO K06547
PhylomeDB Q90460
NextBio 20806658
PRO PR:Q90460
Proteomes UP000000437
GO GO:0016021
GO:0007155
GO:0007275
Gene3D 2.60.40.10
InterPro IPR013162
IPR007110
IPR013783
IPR003006
IPR003599
IPR003596
Pfam PF08205
SMART SM00409
SM00406
PROSITE PS50835
PS00290

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0007155

cell adhesion

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0060536

cartilage morphogenesis

PMID:21073867[1]

IMP: Inferred from Mutant Phenotype

P

5 dpf alcama morphants are characterized by a protruding lower jaw, cardiac edema and absence of swim bladder (Fig. 1G and I). Alcian blue staining of 5 dpf larvae revealed that the percentage of individuals with affected cartilage was equivalent in wild-type (WT) and the p53−/− mutant lines. alcama RNA can rescue the ventral cartilage defect caused by alcama knockdown (Fig. S1). Mc and ch are fused to their respective dorsal elements, palatoquadrate (pq) and hyosymplectic (hm) (Fig. C).

complete
CACAO 1999

GO:0010628

positive regulation of gene expression

PMID:21073867[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010628

positive regulation of gene expression

PMID:21073867[1]

IMP: Inferred from Mutant Phenotype

P

In alcama morphants, the expression of hand2, dlx3b, dlx5a and dlx6a is strongly reduced in the first and the posterior arches, and mildly reduced in the second arch at 30 hpf (Fig. 4B, E, H, K).

complete
CACAO 2068

GO:0010770

positive regulation of cell morphogenesis involved in differentiation

PMID:21073867[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0014033

neural crest cell differentiation

PMID:21073867[1]

IMP: Inferred from Mutant Phenotype

P

Co-injection of alcama RNA with alcama MO decreases the number of affected individuals (absent dlx5a staining) to WT levels. The percentage of affected larvae is similar in WT and p53−/− mutants (Fig. S6D)

complete
CACAO 2076

GO:0010770

positive regulation of cell morphogenesis involved in differentiation

PMID:21073867[1]

IMP: Inferred from Mutant Phenotype

P

5 dpf alcama morphants are characterized by a protruding lower jaw, cardiac edema and absence of swim bladder (Fig. 1G and I). Alcian blue staining of 5 dpf larvae revealed that the percentage of individuals with affected cartilage was equivalent in wild-type (WT) and the p53−/− mutant lines. alcama RNA can rescue the ventral cartilage defect caused by alcama knockdown (Fig. S1).

complete
CACAO 2078

GO:0014033

neural crest cell differentiation

PMID:21073867[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

incorrect (CACAO)

positive regulation of neural crest differentiation

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PMID:21073867[1]

IMP: Inferred from Mutant Phenotype

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Co-injection of alcama RNA with alcama MO decreases the number of affected individuals (absent dlx5a staining) to WT levels. The percentage of affected larvae is similar in WT and p53−/− mutants (Fig. S6D)

Missing: Valid GO ID
CACAO 2079

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0060536

cartilage morphogenesis

PMID:21073867[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Choudhry, P et al. (2011) Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis. Dev. Biol. 349 483-93 PubMed GONUTS page