DANRE:C166A

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	alcama (synonyms: alcam, cd166)
Protein Name(s)	CD166 antigen homolog A Activated leukocyte cell adhesion molecule A DM-GRASP homolog Neurolin
External Links
UniProt	Q90460
EMBL	L25273 L25057
RefSeq	NP_571075.1
UniGene	Dr.20912
ProteinModelPortal	Q90460
PRIDE	Q90460
GeneID	30194
KEGG	dre:30194
CTD	30194
ZFIN	ZDB-GENE-990415-30
eggNOG	NOG148902
HOGENOM	HOG000070101
HOVERGEN	HBG050847
InParanoid	Q90460
KO	K06547
PhylomeDB	Q90460
NextBio	20806658
PRO	PR:Q90460
Proteomes	UP000000437
GO	GO:0016021 GO:0007155 GO:0007275
Gene3D	2.60.40.10
InterPro	IPR013162 IPR007110 IPR013783 IPR003006 IPR003599 IPR003596
Pfam	PF08205
SMART	SM00409 SM00406
PROSITE	PS50835 PS00290

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0007155	cell adhesion	GO_REF:0000037	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0130	P	Seeded From UniProt	complete
	GO:0007275	multicellular organismal development	GO_REF:0000037	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
	GO:0060536	cartilage morphogenesis	PMID:21073867	IMP: Inferred from Mutant Phenotype		P	5 dpf alcama morphants are characterized by a protruding lower jaw, cardiac edema and absence of swim bladder (Fig. 1G and I). Alcian blue staining of 5 dpf larvae revealed that the percentage of individuals with affected cartilage was equivalent in wild-type (WT) and the p53−/− mutant lines. alcama RNA can rescue the ventral cartilage defect caused by alcama knockdown (Fig. S1). Mc and ch are fused to their respective dorsal elements, palatoquadrate (pq) and hyosymplectic (hm) (Fig. C).	complete CACAO 1999
	GO:0010628	positive regulation of gene expression	PMID:21073867	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt	complete
	GO:0010628	positive regulation of gene expression	PMID:21073867	IMP: Inferred from Mutant Phenotype		P	In alcama morphants, the expression of hand2, dlx3b, dlx5a and dlx6a is strongly reduced in the first and the posterior arches, and mildly reduced in the second arch at 30 hpf (Fig. 4B, E, H, K).	complete CACAO 2068
	GO:0010770	positive regulation of cell morphogenesis involved in differentiation	PMID:21073867	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt	complete
	GO:0014033	neural crest cell differentiation	PMID:21073867	IMP: Inferred from Mutant Phenotype		P	Co-injection of alcama RNA with alcama MO decreases the number of affected individuals (absent dlx5a staining) to WT levels. The percentage of affected larvae is similar in WT and p53−/− mutants (Fig. S6D)	complete CACAO 2076
	GO:0010770	positive regulation of cell morphogenesis involved in differentiation	PMID:21073867	IMP: Inferred from Mutant Phenotype		P	5 dpf alcama morphants are characterized by a protruding lower jaw, cardiac edema and absence of swim bladder (Fig. 1G and I). Alcian blue staining of 5 dpf larvae revealed that the percentage of individuals with affected cartilage was equivalent in wild-type (WT) and the p53−/− mutant lines. alcama RNA can rescue the ventral cartilage defect caused by alcama knockdown (Fig. S1).	complete CACAO 2078
	GO:0014033	neural crest cell differentiation	PMID:21073867	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt	complete
incorrect (CACAO)	positive regulation of neural crest differentiation	<input type="hidden" name="field[2]" />	PMID:21073867	IMP: Inferred from Mutant Phenotype		<input type="hidden" name="field[6]" />	Co-injection of alcama RNA with alcama MO decreases the number of affected individuals (absent dlx5a staining) to WT levels. The percentage of affected larvae is similar in WT and p53−/− mutants (Fig. S6D)	Missing: Valid GO ID CACAO 2079
	GO:0016020	membrane	GO_REF:0000037	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
	GO:0016020	membrane	GO_REF:0000039	IEA: Inferred from Electronic Annotation	UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
	GO:0016021	integral component of membrane	GO_REF:0000037	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
	GO:0060536	cartilage morphogenesis	PMID:21073867	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt	complete
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References

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