GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

DANRE:C166A

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) alcama (synonyms: alcam, cd166)
Protein Name(s) CD166 antigen homolog A

Activated leukocyte cell adhesion molecule A DM-GRASP homolog Neurolin

External Links
UniProt Q90460
EMBL L25273
L25057
RefSeq NP_571075.1
UniGene Dr.20912
ProteinModelPortal Q90460
PRIDE Q90460
GeneID 30194
KEGG dre:30194
CTD 30194
ZFIN ZDB-GENE-990415-30
eggNOG NOG148902
HOGENOM HOG000070101
HOVERGEN HBG050847
InParanoid Q90460
KO K06547
PhylomeDB Q90460
NextBio 20806658
PRO PR:Q90460
Proteomes UP000000437
GO GO:0016021
GO:0007155
GO:0007275
Gene3D 2.60.40.10
InterPro IPR013162
IPR007110
IPR013783
IPR003006
IPR003599
IPR003596
Pfam PF08205
SMART SM00409
SM00406
PROSITE PS50835
PS00290

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0060536

cartilage morphogenesis

PMID:21073867[1]

ECO:0000315

P

5 dpf alcama morphants are characterized by a protruding lower jaw, cardiac edema and absence of swim bladder (Fig. 1G and I). Alcian blue staining of 5 dpf larvae revealed that the percentage of individuals with affected cartilage was equivalent in wild-type (WT) and the p53−/− mutant lines. alcama RNA can rescue the ventral cartilage defect caused by alcama knockdown (Fig. S1). Mc and ch are fused to their respective dorsal elements, palatoquadrate (pq) and hyosymplectic (hm) (Fig. C).

complete
CACAO 1999

GO:0010628

positive regulation of gene expression

PMID:21073867[1]

ECO:0000315

P

In alcama morphants, the expression of hand2, dlx3b, dlx5a and dlx6a is strongly reduced in the first and the posterior arches, and mildly reduced in the second arch at 30 hpf (Fig. 4B, E, H, K).

complete
CACAO 2068

GO:0014033

neural crest cell differentiation

PMID:21073867[1]

ECO:0000315

P

Co-injection of alcama RNA with alcama MO decreases the number of affected individuals (absent dlx5a staining) to WT levels. The percentage of affected larvae is similar in WT and p53−/− mutants (Fig. S6D)

complete
CACAO 2076

GO:0010770

positive regulation of cell morphogenesis involved in differentiation

PMID:21073867[1]

ECO:0000315

P

5 dpf alcama morphants are characterized by a protruding lower jaw, cardiac edema and absence of swim bladder (Fig. 1G and I). Alcian blue staining of 5 dpf larvae revealed that the percentage of individuals with affected cartilage was equivalent in wild-type (WT) and the p53−/− mutant lines. alcama RNA can rescue the ventral cartilage defect caused by alcama knockdown (Fig. S1).

complete
CACAO 2078

involved_in

GO:0060536

cartilage morphogenesis

PMID:21073867[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010770

positive regulation of cell morphogenesis involved in differentiation

PMID:21073867[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0014033

neural crest cell differentiation

PMID:21073867[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:21073867[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060042

retina morphogenesis in camera-type eye

PMID:19107846[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-090917-7

P

Seeded From UniProt

complete

involved_in

GO:0060042

retina morphogenesis in camera-type eye

PMID:19107846[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-090917-5

P

Seeded From UniProt

complete

involved_in

GO:0048703

embryonic viscerocranium morphogenesis

PMID:21073867[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110125-5

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:18296487[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:19107846[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

PMID:19107846[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-090917-5

P

Seeded From UniProt

complete

involved_in

GO:0014033

neural crest cell differentiation

PMID:21073867[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110125-5

P

Seeded From UniProt

complete

involved_in

GO:0007409

axonogenesis

PMID:19107846[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-090917-5

P

Seeded From UniProt

complete

involved_in

GO:0001947

heart looping

PMID:23533583[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110125-4

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0002250

adaptive immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1064

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0283

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0279

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Choudhry, P et al. (2011) Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis. Dev. Biol. 349 483-93 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Diekmann, H & Stuermer, CA (2009) Zebrafish neurolin-a and -b, orthologs of ALCAM, are involved in retinal ganglion cell differentiation and retinal axon pathfinding. J. Comp. Neurol. 513 38-50 PubMed GONUTS page
  3. ↑ Bushell, KM et al. (2008) Large-scale screening for novel low-affinity extracellular protein interactions. Genome Res. 18 622-30 PubMed GONUTS page
  4. ↑ Choudhry, P & Trede, NS (2013) DiGeorge syndrome gene tbx1 functions through wnt11r to regulate heart looping and differentiation. PLoS ONE 8 e58145 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=DANRE:C166A&oldid=5935067"