name: NPHP complex
The contents of this box are automatically generated. You can help by adding information to the "Notes"
def: "A protein complex that is located at the ciliary transition zone and consists of the NPHP4 and NPHP1 proteins. It acts as an organiser of the transition zone inner structure, specifically the Y-shaped links, in conjunction with the MKS complex. It is involved in ciliary protein trafficking and is required for correct functioning of the WNT and Hippo signaling pathways." [GOC:cilia, PMID:18337471, PMID:21422230, PMID:21498478, PMID:21555462, PMID:25150219]
comment: Although there is some evidence, it's still unclear if the MKS and NPHP complexes are constituent parts of the ciliary Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the cilium membrane and axoneme.
synonym: "NPHP module" EXACT 
is_a: GO:0032991 ! protein-containing complex
relationship: part_of: GO:0035869 ! ciliary transition zone
Gene Ontology Home
See Help:References for how to manage references in GONUTS.
This category currently contains no pages or media.