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Category:GO:1990728 ! mitotic spindle assembly checkpoint MAD1-MAD2 complex
name: mitotic spindle assembly checkpoint MAD1-MAD2 complex
namespace: cellular_component
def: "A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex." [GOC:bhm, PMID:12006501, PMID:22898774]
comment: An example of this is MAD1 in human (Q9Y6D9) in PMID:12006501 (inferred from physical interaction).
synonym: "MAD1-MAD2 complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: has_part: GO:1990706 ! MAD1 complex
relationship: part_of: GO:0005737 ! cytoplasm
AmiGO
<GOterm>GO:1990728</GOterm>
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