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Category:GO:1990660 ! calprotectin complex
name: calprotectin complex
namespace: cellular_component
def: "A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways." [GOC:bhm, PMID:25417112]
comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay).
synonym: "calprotectin heterodimer" NARROW []
is_a: GO:0032991 ! protein-containing complex
AmiGO
<GOterm>GO:1990660</GOterm>
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