Category:GO:1904091 ! non-ribosomal peptide synthetase activity

name: non-ribosomal peptide synthetase activity
namespace: molecular_function
def: "Catalysis of a multistep reaction that produce non-ribosomal peptides. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization." [PMID:10631508, PMID:17502372]
comment: Examples are the ferrichrome synthetase Sib1 in S. pombe and the peptidyl carrier protein (PCP) module in bacterial nonribosomal peptide synthases (NRPSs), which holds the peptidyl group and acts as a swinging arm, limiting diffusion until the peptide comes into contact with the next enzymatic module in the NRPS process.
synonym: "PCP" RELATED []
synonym: "peptidyl carrier protein" RELATED [GOC:pr]
synonym: "peptidyl carrier protein activity" RELATED []
synonym: "peptidyl carrier protein activity involved in nonribosomal peptide biosynthesis" EXACT []
synonym: "peptidyl carrier protein activity involved in nonribosomal peptide biosynthetic process" EXACT [GOC:pr]
is_a: GO:0003824 ! catalytic activity
relationship: part_of: GO:0019184 ! nonribosomal peptide biosynthetic process
intersection_of: GO:0003824 ! catalytic activity
intersection_of: part_of GO:0019184 ! nonribosomal peptide biosynthetic process

AmiGO <GOterm>GO:1904091</GOterm>
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