Category:GO:0141221 ! histone deacetylase activity, hydrolytic mechanism

name: histone deacetylase activity, hydrolytic mechanism
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N6-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone]." [PMID:24691964, PMID:28450737, RHEA:58196]
comment: Histone deacytylase (HDAC) enzymes are divided into four classes: the Class I Rpd3-like proteins (in human: HDAC1, HDAC2, HDAC3, and HDAC8); the Class II Hda1-like proteins (in human: HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10); the Class III Sir2-like proteins (in human: SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, and SIRT7); and the Class IV protein (HDAC11 in human). Except for Class III enzymes, the mechanism is a metal-dependent hydrolysis of the acetylated substrate. The Class III HDACs use NAD+ as a reactant to deacetylate acetyl lysine residues of protein substrates forming nicotinamide, the deacetylated product, and the metabolite 2'-O-acetyl-ADP-ribose. Therefore, Class III are classified as transferases (EC:2) and others are hydrolases (EC:3).
synonym: "histone deacetylase activity" BROAD []
synonym: "histone deacetylase activity, NAD-independent" EXACT []
xref: EC:3.5.1.98
xref: MetaCyc:3.5.1.98-RXN
xref: RHEA:58196
is_a: GO:0004407 ! histone deacetylase activity
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

AmiGO <GOterm>GO:0141221</GOterm>
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