Category:GO:0141167 ! chromosomal 5-methylcytosine DNA demethylation, oxidation pathway

name: chromosomal 5-methylcytosine DNA demethylation, oxidation pathway
namespace: biological_process
def: "An epigenetic cytosine DNA demethylation pathway that starts with the enzymatic oxidation of the 5-methylcytosine (5meC) to generate 5-hydroxymethylcytosine (5hmC), which successively converted to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). A DNA glycosylase (e. g. TDG) recognizes the intermediate bases 5fC and 5caC and excises the modified base to initiate its replacement with unmethylated cytosine through base excision repair." [PMID:21862972, PMID:29875631, PMID:36478523]
comment: Note that this term describes one of the biochemical pathways of chromosomal cytosine demethylation but is agnostic to the effect on gene expression. If the data supports it, consider co-annotating to 'positive regulation of gene expression, epigenetic ; GO:0044029' or a child. A similar pathway may also convert chromosomal DNA N6-methyladenosine to adenosine but little evidence exists for this pathway.
synonym: "epigenetic 5-methylcytosine DNA demethylation, oxidation pathway" RELATED []
synonym: "epigenetic DNA demethylation, oxidation pathway" RELATED []
is_a: GO:0141137 ! positive regulation of gene expression, epigenetic
is_a: GO:0141166 ! chromosomal 5-methylcytosine DNA demethylation pathway

AmiGO <GOterm>GO:0141167</GOterm>
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