Category:GO:0141128 ! symbiont-mediated non-specific activation of host T-cells

name: symbiont-mediated non-specific activation of host T-cells
namespace: biological_process
def: "A process by which a symbiont superantigen elicits a strong immune response by activating a large number of T cells in a non-specific manner. Unlike conventional antigens, which activate T cells by interacting with specific receptors on the surface of these cells, superantigens can stimulate T cells by binding to regions outside the antigen-binding site. Superantigens can activate a large proportion of T cells, leading to an exaggerated immune response. This excessive activation can result in the release of a large amount of cytokines such as tumor necrosis factor and interleukin-2. The massive cytokine release can lead to an acute toxic shock, causing symptoms such as fever and organ damage." [PMID:12679262, PMID:17427250, PMID:28880920]
synonym: "symbiont-mediated non-specific T-cell activation in host" EXACT []
synonym: "symbiont-mediated nonspecific activation of host T-cells" EXACT []
is_a: GO:0052553 ! symbiont-mediated perturbation of host immune response

AmiGO <GOterm>GO:0141128</GOterm>
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