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Category:GO:0140991 ! piRNA-mediated gene silencing by mRNA destabilization
name: piRNA-mediated gene silencing by mRNA destabilization
namespace: biological_process
def: "A cytoplasmic post-transcriptional gene silencing pathway in which piRNAs direct the cleavage of target mRNAs. The target mRNA, often transcribed from a transposable element, is destabilized by the activity of a PIWI class endonuclease within the piRNA-induced silencing complex. This may also be accompanied by mRNA deadenylation and decapping." [PMID:29281264, PMID:33419460]
is_a: GO:0035194 ! regulatory ncRNA-mediated post-transcriptional gene silencing
is_a: GO:0061157 ! mRNA destabilization
AmiGO
<GOterm>GO:0140991</GOterm>
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