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Category:GO:0140958 ! target-directed miRNA degradation
name: target-directed miRNA degradation
namespace: biological_process
def: "The process in which a miRNA is targeted for degradation by a non-coding RNA or mRNA. The binding of an RNA to a target miRNA within a RISC complex results in either ubiquitin-mediated degradation of AGO protein or the displacement of the 3' end of the miRNA, exposing it to nucleases." [PMID:33184237, PMID:36150386]
synonym: "target-directed microRNA degradation" EXACT []
synonym: "TDMD" EXACT []
is_a: GO:0010587 ! miRNA catabolic process
is_a: GO:0016441 ! post-transcriptional gene silencing
is_a: GO:0060965 ! negative regulation of miRNA-mediated gene silencing
AmiGO
<GOterm>GO:0140958</GOterm>
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