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Category:GO:0140730 ! amphiregulin production
name: amphiregulin production
namespace: biological_process
def: "The appearance of amphiregulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor." [PMID:24463227]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "AREG production" BROAD []
is_a: GO:0001816 ! cytokine production
AmiGO
<GOterm>GO:0140730</GOterm>
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Child Terms
This category has the following 2 subcategories, out of 2 total.
