Category:GO:0140719 ! constitutive heterochromatin formation

name: constitutive heterochromatin formation
namespace: biological_process
def: "The compaction of chromatin into heterochromatin, a conformation that is refractory to transcription. Constitutive heterochromatin cannot be converted back to euchromatin, the transcriptionally-active conformation. In metazoa, this involves the methylation of histone H3K9." [PMID:17936700]
comment: Note that constitutive heterochromatin usually cannot be reprogrammed to a transcriptionally-competent state, as opposed to facultative heterochromatin, which can be reprogrammed. Note also that constitutive usually involves DNA methylation, while facultative heterochromatin formation does not.
synonym: "constitutive heterochromatin assembly" EXACT []
is_a: GO:0031507 ! heterochromatin formation

AmiGO <GOterm>GO:0140719</GOterm>
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