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Category:GO:0099126 ! transforming growth factor beta complex
name: transforming growth factor beta complex
namespace: cellular_component
def: "A protein complex acting as ligand of the transforming growth factor beta receptor complex, typically a homodimer of any of the TFGbeta isoforms. The precursor of TGFbeta proteins is cleaved into mature TGFbeta and the latency-associated peptide (LAP), which remains non-covalently linked to mature TGFbeta rendering it inactive. TGFbeta is activated by dimerization and dissociation of the LAP." [GOC:bhm, PMID:22943793]
synonym: "TGF-beta complex" EXACT []
synonym: "TGF-beta dimer" EXACT []
synonym: "TGFB complex" EXACT []
synonym: "TGFB dimer" EXACT []
synonym: "TGFbeta complex" EXACT []
synonym: "TGFbeta dimer" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of: GO:0062023 ! collagen-containing extracellular matrix
AmiGO
<GOterm>GO:0099126</GOterm>
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