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Category:GO:0090625 ! siRNA-mediated gene silencing by mRNA destabilization
name: siRNA-mediated gene silencing by mRNA destabilization
namespace: biological_process
def: "An siRNA-mediated post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:15260970]
synonym: "gene silencing by mRNA cleavage" BROAD []
synonym: "mRNA cleavage involved in gene silencing by siRNA" EXACT []
synonym: "mRNA destabilization-mediated gene silencing by siRNA" EXACT []
is_a: GO:0061157 ! mRNA destabilization
is_a: GO:0140766 ! siRNA-mediated post-transcriptional gene silencing
AmiGO
<GOterm>GO:0090625</GOterm>
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