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Category:GO:0070745 ! interleukin-35 complex
name: interleukin-35 complex
namespace: cellular_component
def: "A protein complex that is composed of an interleukin-12 alpha subunit (p35, product of the IL12A gene) and an EBI3 subunit and is secreted into the extracellular space." [GOC:add, PMID:19161428, PMID:19161429]
comment: Note that this heterodimeric cytokine utilizes the same IL-12p35 subunit as its alpha chain as IL-12 uses and the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-27 uses. IL-35 requires both subunits -- there is no separate IL35 gene.
synonym: "EBI3" NARROW [GOC:add]
synonym: "IL-35 complex" EXACT [GOC:add]
synonym: "IL12A" NARROW [GOC:add]
synonym: "p35" NARROW [GOC:add]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of: GO:0005615 ! extracellular space
AmiGO
<GOterm>GO:0070745</GOterm>
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