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Category:GO:0070744 ! interleukin-27 complex
name: interleukin-27 complex
namespace: cellular_component
def: "A protein complex that is composed of an interleukin-27p28 subunit (product of the IL27 gene) and an EBI3 subunit and is secreted into the extracellular space." [GOC:add, PMID:15999093, PMID:19161428]
comment: Note that this heterodimeric cytokine utilizes the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-35 uses for its beta chain. Also note that the product of the IL27 gene is the alpha subunit of IL-27. The functional IL-27 protein complex requires both subunits.
synonym: "EBI3" NARROW [GOC:add]
synonym: "IL-27 complex" EXACT [GOC:add]
synonym: "IL27" NARROW [GOC:add]
synonym: "p28" NARROW [GOC:add]
is_a: GO:0032991 ! protein-containing complex
relationship: part_of: GO:0005615 ! extracellular space
AmiGO
<GOterm>GO:0070744</GOterm>
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