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Category:GO:0044824 ! retroviral 3' processing activity
name: retroviral 3' processing activity
namespace: molecular_function
def: "The catalysis of the removal of two di- or tri-nucleotides from each 3' end of double-stranded viral DNA, exposing recessed 3' hydroxyls." [PMID:22580823, Reactome:R-HSA-164522]
comment: This reaction may serve to remove heterogeneous extra bases from the viral DNA end, and to stabilize the integrase-DNA complex. The chemistry of cleavage is a simple hydrolysis by single-step transesterification.
synonym: "3' processing reaction" EXACT []
synonym: "3'-processing activity" EXACT []
is_a: GO:0004520 ! DNA endonuclease activity
relationship: part_of: GO:0044823 ! retroviral integrase activity
AmiGO
<GOterm>GO:0044824</GOterm>
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