name: calcineurin-NFAT signaling cascade
def: "Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G-protein coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+)." [GOC:lm, GOC:mah, PMID:12975316, PMID:15928679]
synonym: "calcineurin-NFAT signaling pathway" RELATED [GOC:bf]
synonym: "calcineurin-NFAT signalling pathway" RELATED 
is_a: GO:0048016 ! inositol phosphate-mediated signaling
is_a: GO:0097720 ! calcineurin-mediated signaling
Gene Ontology Home
The contents of this box are automatically generated. You can help by adding information to the "Notes"
|Last version checked|
See Help:References for how to manage references in GONUTS.
This category has the following 5 subcategories, out of 5 total.
Pages in category "GO:0033173 ! calcineurin-NFAT signaling cascade"
The following 5 pages are in this category, out of 5 total.
Jump to pages starting with: C M P