Category:GO:0030210 ! heparin proteoglycan biosynthetic process

name: heparin proteoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heparin proteoglycans, which consist of a core protein linked to a heparin glycosaminoglycan. The heparin chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparin is similar to heparan sulfate but it contains more N-sulfate and O-sulfate groups. Heparin chains are covalently linked to serine/threonine residues (O-linked) of the core protein via a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate)." [PMID:22566225]
synonym: "heparan sulfate biosynthetic process" RELATED []
synonym: "heparin anabolism" EXACT []
synonym: "heparin biosynthesis" EXACT []
synonym: "heparin formation" EXACT []
synonym: "heparin synthesis" EXACT []
is_a: GO:0030202 ! heparin proteoglycan metabolic process
is_a: GO:0180064 ! protein O-linked glycosylation via xylose

AmiGO <GOterm>GO:0030210</GOterm>
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